Create issue ticket

1,625 Possible Causes for DEFECT,, IODIDE, ORGANIFICATION, TOTAL, TYR453ASP

  • Congenital Hypothyroidism

    Abstract The aim of this study was to identify the genetic defect of a patient with dyshormonogenetic congenital hypothyroidisms (CH) with total iodide organification defect[ncbi.nlm.nih.gov] CH is most often caused by defects in thyroid development leading to thyroid dysgenesis.[ncbi.nlm.nih.gov] BACKGROUND: Iodide transport defects (ITDs), rare causes of congenital hypothyroidism (CH), have been shown to arise from abnormalities of the sodium/iodide symporter (NIS[ncbi.nlm.nih.gov] A total of 3,900, 3,991, and 4,050 live births occurred in 2012, 2013, and 2014, respectively.[ncbi.nlm.nih.gov] METHODS: In the child with the organification defect, TPO, DUOX2, and DUOXA2 genes were analyzed.[ncbi.nlm.nih.gov]

    Missing: TYR453ASP
  • Metabolic Alkalosis

    […] as 43.2 34.19 mg/kg/day (a total of 647.70 mg/kg in 15 days).[ncbi.nlm.nih.gov] INTRODUCTION: Pendred syndrome, a combination of sensorineural deafness, impaired organification of iodide in the thyroid and goitre, results from biallelic defects in pendrin[ncbi.nlm.nih.gov] The defect associated with CF is in the cystic fibrosis transmembrane regulator (CFTR), which acts primarily as a chloride channel.[ncbi.nlm.nih.gov] J David Erickson, DDS, Birth Defects and Genetic Diseases Br, Div of Birth Defects and Developmental Disabilities, National Center for Environmental Health; Jose Cordero,[cdc.gov] RESULTS: A total of 51 patients were included in the study. The time of rising serum sodium and hypernatremia was accompanied by metabolic alkalosis.[ncbi.nlm.nih.gov]

    Missing: TYR453ASP
  • Nontoxic Goiter

    BACKGROUND: Total thyroidectomy for treatment of Graves' disease is controversial and much of the debate centers on the concern for complications.[ncbi.nlm.nih.gov] These findings suggest the correlation of an iodide organification defect with a cytochrome b5 reductase deficiency.[ncbi.nlm.nih.gov] […] oxidase defect; deiodinase deficiency; coupling defect; and an abnormality . . .[nejm.org] Transforming growth factor beta protein secretion by cultured thyroid follicular cells was also low in nontoxic goiter, but could be increased by addition of sodium iodide[ncbi.nlm.nih.gov] Polosa P. 1978 45 Nontoxic goiter-diffuse or nodular. ( 1174255 ) Maloof F....Vickery A.L. 1975 46 Deficient cytochrome b5 reductase activity in nontoxic goiter with iodide organification[malacards.org]

    Missing: TYR453ASP
  • Thyrotropin

    RESULTS: Postmenopausal women had lower serum TSH concentrations and higher levels of total cholesterol, low-density lipoprotein cholesterol (LDLc), high-density lipoprotein[ncbi.nlm.nih.gov] This implies that some pendrin mutations may involve direct stimulation of thyroid cell proliferation with no TSH hyperstimulation and no iodine organification defect.[ncbi.nlm.nih.gov] Conceptually, defects leading to RTSH impair both aspects of TSH-mediated action, namely thyroid hormone synthesis and gland growth.[ncbi.nlm.nih.gov] TSH/IGF-1 co-treatment elicited additive effects on thyroglobulin (TG), thyroperoxidase (TPO), and deiodinase type 2 (DIO2) mRNA levels but synergistic effects on sodium-iodide[ncbi.nlm.nih.gov] […] significantly higher 2-h radioiodide uptake and 2- to 24-h radioiodide uptake ratios compared with heterozygous, unaffected family members, suggesting an imbalance between iodide[ncbi.nlm.nih.gov]

    Missing: TYR453ASP
  • Pendred's Syndrome

    Although the serum total T4 was low (2.4 mug/100 ml) and TSH was significantly high (181 muU/ml), the serum total T3 was normal (152 ng/100ml).[ncbi.nlm.nih.gov] Although Pendred's syndrome may cause up to 7.5% of all cases of congenital deafness, the molecular basis of the association between the hearing loss and the thyroid organification[ncbi.nlm.nih.gov] In these patients we could not demonstrate any of the well-established biochemical defects associated with familial goiter.[ncbi.nlm.nih.gov] Goiter development and development of hypothyroidism are variable and depend on nutritional iodide intake.[scholars.northwestern.edu] The serum total thyroxine and serum total triiodothyronine concentrations were normal in 8, of whom 3 had elevated serum TSH concentrations.[ncbi.nlm.nih.gov]

    Missing: TYR453ASP
  • Methimazole

    Laboratory data showed total serum insulin level 320 microU/mL, free insulin 55 microU/mL and insulin antibody 88.3%.[ncbi.nlm.nih.gov] Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Boiling Point: No Data Available Applications: Methimazole is a thiourea antithyroid agent that prevents iodine organification[trc-canada.com] The defect of the scalp was well healed after 6 weeks, but the skull defect remained unclosed.[ncbi.nlm.nih.gov] Flashcards in Sketchy Pharm: Propylthiouracil, Methimazole, and Levothyroxine Deck (18): Iodide enters the follicular cells through ______________ channels. sodium/iodide[brainscape.com] Irinotecan pharmacokinetics and side effects were followed during a total of four courses (two courses with and two courses without methimazole).[ncbi.nlm.nih.gov]

    Missing: TYR453ASP
  • Low Sodium Diet

    A total of 56 patients (72.7%) completed the study, 26 on a low-sodium diet (LD) and 30 on their usual diet (UD).[ncbi.nlm.nih.gov] CONCLUSIONS: These studies indicate that a low-sodium diet corrects the defect in both vascular and lymphocyte beta-adrenergic responsiveness with aging.[ncbi.nlm.nih.gov] […] low-sodium diet a diet that limits the intake of salt sodium iodide a crystalline salt used like potassium iodide closed-minded not ready to receive to new ideas low-salt[vocabulary.com] METHODS: A total of 254 patients (57% male, 62 14 years, 52% New York Heart Association class III/IV, ejection fraction of 36% 14%) were recruited from outpatient HF clinics[ncbi.nlm.nih.gov] Dietary sodium may be an important factor in the beta-receptor defect in early hypertension.[ncbi.nlm.nih.gov]

    Missing: ORGANIFICATION TYR453ASP
  • Hypothyroidism

    A total of 9 studies were selected, totalizing the inclusion of 1,537 euthyroid PCOS and 301 SCH-PCOS.[ncbi.nlm.nih.gov] Excess iodine, as in radiocontrast dyes, amiodarone, health tonics (herbal and dietary supplements), and seaweed, can transiently inhibit iodide organification and thyroid[emedicine.medscape.com] CONCLUSIONS: This study, including the identification of a second, novel, TSHB deletion, expands the molecular spectrum of TSHB defects and suggests that allele loss may be[ncbi.nlm.nih.gov] Whatever the underlying cause may be, the defect is clearly centred on the gland itself.[symptoma.com] There was no difference between total cholesterol, triglyceride, and low-density lipoprotein levels in SHT patients and controls.[ncbi.nlm.nih.gov]

    Missing: TYR453ASP
  • Calcitonin

    Primary objective of this study was to find the change in calcitonin in the postoperative period after total thyroidectomy.[ncbi.nlm.nih.gov] […] iodine molecules are attached to the tyrosyl residues of tyroglobuline in the process of iodination of tyrosine ( organification ).[fblt.cz] METHODS: We conducted the calcium stimulation test using ECLIA in 21 men with non-medullary thyroid carcinoma (non-MTC), before and after total thyroidectomy.[ncbi.nlm.nih.gov] METHODS: IFFP and synovial (SYN) tissues were harvested from 100 individuals with radiographic knee OA (unilateral Kellgren/Lawrence [K/L] grades 2-4) during total knee arthroplasty[ncbi.nlm.nih.gov] One hundred adult patients undergoing total thyroidectomy, with at least three parathyroids being preserved were included.[ncbi.nlm.nih.gov]

    Missing: DEFECT TYR453ASP
  • Postpartum Thyroiditis

    RESULTS: Titers of total TPOAb and its IgG subtypes were lowest before delivery in PPT patients. Following delivery, titers of total TPOAb increased.[ncbi.nlm.nih.gov] We have studied 11 euthyroid women with a previous history of PPT to determine the incidence of subtle defects in thyroid function measured by iodide-perchlorate (I-ClO4)[ncbi.nlm.nih.gov] […] patients iodide may aggravate rather than ameliorate the disease.[ncbi.nlm.nih.gov] Abstract Unreliable estimates of serum total T3 due to the presence of autoantibodies against T3 were observed in a woman who developed thyrotoxicosis followed by transient[ncbi.nlm.nih.gov] […] symptoms and disorientation related to a postpartum thyroiditis in a woman with a pre-existing mood disorder; or (4) both psychosis and thyroiditis caused by a pre-existing defect[ncbi.nlm.nih.gov]

    Missing: TYR453ASP