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5,258 Possible Causes for DNA, complex, multiprotein, replication

  • Novobiocin

    […] stage in replication.[] Unlike previously identified N-terminal Hsp90 inhibitors, EGCG does not appear to prevent Hsp90 from forming multiprotein complexes.[] Novobiocin at 500 micrograms/ml or at higher concentrations irreversibly inactivated DNA polymerase alpha primase complex.[] […] reports from this laboratory have demonstrated that novobiocin produces supraadditive cytotoxicity and increases the formation of drug-stabilized topoisomerase II-DNA covalent complexes[]

  • Ehrlichia Chaffeensis

    Silencing of these genes in the eyes, wings, or the salivary glands did not impact fly susceptibility or bacterial replication.[] Abstract During infection, some intracellular pathogenic bacteria use a dedicated multiprotein complex known as the type IV secretion system to deliver type IV effector (T4E[] This suggests that TRP120 folds into an ordered structure upon forming a protein-DNA complex, and thus folding of TRP120 TR is coupled with DNA binding.[] Abstract In the United States, human ehrlichiosis is a complex of emerging tick-borne diseases caused by 3 distinct Ehrlichia species: Ehrlichia chaffeensis, Ehrlichia ewingii[]

  • Bloom Syndrome

    Consistent with this notion, WRN and BLM localize to sites of blocked replication after certain DNA-damaging treatments and exhibit enhanced activity on replication and recombination[] Our study provides the first biochemical characterization of a multiprotein FA complex and suggests a connection between the BLM and FA pathways of genomic maintenance.[] The BLM DNA helicase participates in genomic stability at ribosomal DNA repeats and telomeres.[] Abstract BLM, the helicase defective in Bloom syndrome, is part of a multiprotein complex that protects genome stability.[]

  • Septic Shock

    However, three recent, goal-directed therapy trials failed to replicate the originally reported mortality reductions, prompting a debate on how this early resuscitation should[] Contrary to the highly regulated multiprotein platform required for caspase-1 activation in the canonical inflammasomes, the non-canonical mouse caspase-11 and the orthologous[] Oxidative DNA damage was evaluated by 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels.[] A decision-support tool trained on electronic health record data, can help improve this complex decision.[]

  • Herpes Simplex Virus 1

    IMPORTANCE Many human DNA viruses transcribe their genomes and replicate in the nucleus of a host cell, where they exploit the host cell nuclear machinery for their own replication[] ., but not with ICP8 or ICP27, presumably in a multiprotein complex.[] Polymerase chain reaction detected HSV-1 DNA in the CSF during acute encephalitis but not thereafter.[] […] of infected cells to their surroundings through modulating the activity of focal adhesion complexes.[]

  • Fanconi Anemia

    KEYWORDS: DNA damage; DNA repair; DNA replication; Fanconi anemia; gene knock-out; genomic instability; nucleases; replication stress[] Fanconi Anemia Complementation Group Proteins/genetics Fanconi Anemia Complementation Group Proteins/metabolism* Humans Inhibitor of Differentiation Protein 2/metabolism Multiprotein[] FA proteins act at different steps of ICL repair in sensing, recognition and processing of DNA lesions.[] Given that HES1 interacts with members of the FA core complex, the aim of this study was to determine whether HES1 is mono-ubiquitinated via the FA core complex.[]

  • Pneumonia

    […] levels similar to those induced by wild-type RSV replicating to a 5- to 25-fold-higher titer.[] […] protected brush biopsy of the lower respiratory tract were performed, which indicated herpes virus-infected cells with nuclear inclusions; PCR assay was positive for HSV DNA[] Kingdom of Saudi Arabia; King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia; Hera General Hospital, Makkah, Kingdom of Saudi Arabia; King Abdullah Medical Complex[] People in cold climates especially vulnerable DNA cost 3 Severity increase Slight Lethality None (Slight in Smallpox and VS) Infectivity increase Average; Great in Cold climates[]

    Missing: multiprotein
  • Hepatitis C Virus

    LY294002 inhibited HCV replication via HO-1 down-regulation. Constitutive expressed p-AKT was not involved in hypericin-induced reduction in HCV replication.[] Abstract RAD51-associated protein 1 (RAD51AP1) is a member of the multiprotein complexes postulated to carry out RAD51-mediated homologous recombination and DNA repair in[] HCV-associated GN occurs due to HCV-induced lymphoproliferation, leading to the generation of pathogenic immune complexes, including complexes containing cryoglobulins.[] How viral fitness can influence the mutant spectrum complexity of a viral quasispecies subjected to lethal mutagenesis has not been investigated.[]

  • Herpes Simplex Virus 1 Infection

    The disruption of F-actin dynamics by chemical inhibitors significantly reduced the efficiency of viral infection and intracellular HSV-1 replication.[] Abstract Inflammasomes are multiprotein complexes that recognize pathogens and pathogen- or danger-associated molecular patterns.[] , DNA fragmentation and annexin V binding).[] Abstract During herpes simplex virus 1 (HSV-1) infection there is a loss of the serine-2 phosphorylated form of RNA polymerase II (RNAP II) found in elongation complexes.[]

  • Chlamydia Infection

    Here, we show that C. caviae enters, replicates, and performs a complete developmental cycle in Drosophila SL2 cells.[] METHOD: The polymerase chain reaction (PCR) on fallopian tube tissue was applied to detect Chlamydia DNA in 42 patients with EP (EP group) and 87 patients without EP (control[] Abstract Using a modified one-dimensional model for the spread of an SIS disease on a network, we show that the behaviour of complex network simulations can be replicated[] Cp DNA was equally prevalent in non-OAL, nodal, and extranodal lymphomas: among the latter, it was more common in diffuse large B-cell lymphomas of the skin (P 0.03) and Waldeyer's[]