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3,394 Possible Causes for Dioxin, Nuclear, Receptor,, Translocator

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  • Spinal and Bulbar Muscular Atrophy

    In motoneurons, testosterone triggers nuclear toxicity by inducing AR nuclear translocation.[ncbi.nlm.nih.gov] We were unable to find androgen receptor (AR) in the scrotal skin of three patients with SBMA, and propose that AR abnormality is the cause of the disease.[ncbi.nlm.nih.gov] Androgen receptor (AR), a disease-causing protein of SBMA, is a well-characterized ligand-activated transcription factor, and androgen binding induces nuclear translocation[ncbi.nlm.nih.gov] Abstract Polyglutamine expansion within the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA) and is associated with misfolded and aggregated species[ncbi.nlm.nih.gov]

    Missing: Dioxin
  • Influenza

    To insure efficient transport across the nuclear membrane, these viruses use nuclear import and export signals exposed on the vRNPs.[ncbi.nlm.nih.gov] […] recognizing SAα2,3Gal can be transmitted from birds to humans, they can replicate efficiently only in cells in the lower region of the respiratory tract, where the avian-virus receptor[doi.org] Electron density of the receptors.[doi.org] Surprisingly, the majority of viruses experience their initial acidification in the perinuclear region immediately following the dynein-directed rapid translocation step.[doi.org]

    Missing: Dioxin
  • Translocation Renal Cell Carcinoma

    nuclear immunoreactivity for TFE3.[ncbi.nlm.nih.gov] […] feasibility and opportunity of treating such a patient with multiple line of tyrosine kinase inhibitor (TKI) targeting vascular endothelial and platelet-derived growth factor receptors[ncbi.nlm.nih.gov] In recent years, at least 6 different Xp11.2 translocation RCCs have been identified and characterized at the molecular level.[ncbi.nlm.nih.gov] Immunohistochemically, the tumor cells marked with TFE3, focally marked with smooth muscle actin, HMB-45, CD68, progesterone receptor (PR) and CD10 but did not mark with epithelial[ncbi.nlm.nih.gov]

    Missing: Dioxin
  • Promyelocytic Leukemia

    During cell division, a large number of nuclear proteins are released into the cytoplasm due to nuclear envelope breakdown.[ncbi.nlm.nih.gov] It could form homodimers and also heterodimers with retinoid X receptor α.[ncbi.nlm.nih.gov] […] clone presenting a t(1;2)(q42 43;q11.2 12) translocation as an additional abnormality.[ncbi.nlm.nih.gov] Abstract Acute promyelocytic leukemia (APL) is a distinctive subtype of acute myeloid leukemia (AML) in which the hybrid protein promyelocytic leukemia protein/retinoic acid receptor[ncbi.nlm.nih.gov]

    Missing: Dioxin
  • Tamoxifen

    […] others from cell extracts of the parental cells (MCF-7), TAM-resistant cells (MCF-7/TAM) and CK-α knockdown cells (MCF-7/shCK-α, MCF-7/TAM/shCK-α) were analyzed by proton nuclear[ncbi.nlm.nih.gov] However, ER-regulated gene products, including total IGF-IR itself and progesterone receptor, remained suppressed even at the time of acquired resistance.[ncbi.nlm.nih.gov] (TCDD); "dioxin" Thiotepa Thorium dioxide Tobacco smoke, environmental Tobacco, smokeless Tobacco smoking o‑Toluidine Trichloroethylene (TCE) Vinyl chloride Ultraviolet ([cancer.org] In addition, knockdown of pyruvate kinase M2 upregulated the level of cleaved Caspase-3 and subsequently facilitated the nuclear translocation of mammalian sterile 20-like[ncbi.nlm.nih.gov]

  • Urinary Tract Infection

    Author information 1 Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. 2 Department of Nuclear Medicine[ncbi.nlm.nih.gov] Well-known steps in the pathogenesis of UTIs are urogenital colonization and adherence of uropathogens to uroepithelial cell receptors.[ncbi.nlm.nih.gov] We hypothesised that in hospitalised patients, UPEC strains might translocate from the gut to the blood stream and that this could be due to the presence of virulence genes[ncbi.nlm.nih.gov] Anne, Toulon, France. 3 Center for Microbial Ecology, Nocardiosis French Observatory, School of Pharmacy, University Claude Bernard Lyon 1, Lyon, France. 4 Department of Nuclear[ncbi.nlm.nih.gov]

    Missing: Dioxin
  • Estrogenic Agents

    ., an orphan nuclear receptor on which estrogens often trigger unfavorable events, was not observed.[ncbi.nlm.nih.gov] […] dose-dependent response of D2 dopamine receptor, D4 dopamine receptor or ER alpha receptor subtypes.[cebp.aacrjournals.org] Another public health aspect of hormones was suggested as early as 1962 when Rachel Carson described in her book Silent Spring how man‐made chemicals, such as dioxins, dichlorodiphenyltrichloroethane[doi.org] Definition (NCI) A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of[fpnotebook.com]

  • Raloxifene

    OBJECTIVES: This study aims to asses the effects of estradiol vs. raloxifene on the levels of osteoprotegerin and soluble Receptor Activator of Nuclear Factor kB Ligand (sRANKL[ncbi.nlm.nih.gov] The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity.[ncbi.nlm.nih.gov] Moreover, raloxifene promoted the translocation of EGFR into endosomes associated with decreased cell migration, cell invasion and tumorigenicity in vitro.[ncbi.nlm.nih.gov] Tumors exposed to raloxifene, bexarotene and/or the combination showed significant suppression of proliferating cell nuclear antigen, cyclin D1, and β-catenin with an increased[ncbi.nlm.nih.gov]

  • Epstein Barr Virus

    More specifically, EBNA3C directly binds to cyclin D2 and they colocalize together in nuclear compartments.[ncbi.nlm.nih.gov] Complement receptor 1/CD35 is a receptor for mannan-binding lectin.[ncbi.nlm.nih.gov] (TCDD or dioxin).[ncbi.nlm.nih.gov] ., the translocation of the c- myc oncogene in Burkitt's lymphoma) interact?[doi.org]

  • Retinoid

    Abstract The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization[ncbi.nlm.nih.gov] Karyotype analysis and RNA-Seq revealed the presence of a novel t(4;15)(q31;q22) reciprocal translocation involving the TMEM154 and RASGRF1 genes.[ncbi.nlm.nih.gov] (Arg66*)) in RORB, which encodes the beta retinoid-related orphan nuclear receptor (RORβ), in four affected family members. In addition, two de novo variants (c.218T C/p.[ncbi.nlm.nih.gov] BACKGROUND: BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2.[ncbi.nlm.nih.gov]

    Missing: Dioxin