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128 Possible Causes for E1A associated, human, p130, protein

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  • Papillomaviridae

    Galloway DOI: 10.1128/JVI.80.10.4664-4672.2006 ABSTRACT The variable surface loops on human papillomavirus (HPV) virions required for type-specific neutralization by human[doi.org] HPV E7 interacts with and inactivates the retinoblastoma protein (pRb) and the pRb-related proteins p107 and p130 ( 40 ).[doi.org] In vitro cleavage of BPV L2 proteins.[doi.org] Association of the E7 protein with pRb promotes cell proliferation by the same mechanism as the E1A proteins of adenoviruses and SV40 large T antigen.[microbewiki.kenyon.edu]

  • Adenovirus

    […] complications Adenovirus Infections, Human/virology* Adenoviruses, Human/genetics* Adenoviruses, Human/physiology* Adolescent Adult Antigens, Viral, Tumor/genetics BK Virus[ncbi.nlm.nih.gov] KEYWORDS: 22K; 33K; 52K; BAdV-3; NLS; Protein- protein interaction[ncbi.nlm.nih.gov] We recently reported that E1A and E1A 1-80 (N-terminal 80 aa) promote association of the proto-oncogene product MYC with the NuA4 complex.[ncbi.nlm.nih.gov] […] mastadenovirus E Human adenovirus E overview Lineage: Viruses [ 13573 ]; dsDNA viruses, no RNA stage [ 7036 ]; Adenoviridae [ 79 ]; Mastadenovirus [ 50 ]; Human mastadenovirus[ncbi.nlm.nih.gov]

    Missing: p130
  • AOMS3

    A first-draft human protein-interaction map . Genome Biol. 5 , R63 (2004) 17. Rual, J. F. et al. Human ORFeome version 1.1: a platform for reverse proteomics .[doi.org] 2258 – 2269 . 14. (2011) Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130[academic.oup.com] A form of the metabolic syndrome associated with mutations in DYRK1B. N. Engl. J. Med. 370 , 1909–19 (2014). 8. Glenewinkel, F. et al .[nature.com] […] mRNAs Spliced ESTs Human ESTs Other ESTs Other mRNAs SIB Alt-Splicing Expression GTEx Gene GTEx Transcript Affy GNF1H Affy U133 Affy U95 GNF Atlas 2 GWIPS-viz Riboseq miRNA[genome.ucsc.edu]

  • Human Herpesvirus 8

    In 1994, Chang and Moore reported on the latest of the gammaherpesviruses to infect humans, human herpesvirus 8 (HHV-8).[ncbi.nlm.nih.gov] […] response signaling in addition to enhancing viral protein folding.[ncbi.nlm.nih.gov] Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. J. Virol. 68 : 2206 -2214. Sun, R., S.-F. Lin, K.[doi.org] In humans, these are termed human cytomegalovirus (HCMV or herpesvirus 5), human herpesviruses 6A and 6B (HHV-6A and -6B), and human herpesvirus 7 (HHV-7).[doi.org]

    Missing: p130
  • Malignant Neoplasm

    Human cancers exhibit genomic instability and an increased mutation rate due to underlying defects in DNA repair genes.[ncbi.nlm.nih.gov] The mutant derivative LTK1 inactivates only p53, while LTΔ434–444 inactivates only pRb and its family members (p107 and p130) ( 27 ).[pnas.org] […] of the Hmga1 protein and the Brca1 gene.[doi.org] Fearon The author is in the Division of Molecular Medicine and Genetics, Departments of Internal Medicine, Human Genetics, and Pathology, University of Michigan Medical Center[doi.org]

    Missing: E1A associated
  • JC Virus

    […] matching the structure of human populations, with any mismatch caused by recent human admixture.[doi.org] […] virus (JCV) is a polyomavirus that infects approximately 75% of the population and encodes a T antigen (T-Ag) gene, which is oncogenic and inactivates the p53 and pRb/p107/p130[ncbi.nlm.nih.gov] When produced in a reconstituted in vitro protein translation system, these two mutant proteins were stable, suggesting that some cellular factors were responsible for their[ncbi.nlm.nih.gov] […] human proteins, and also prokaryotic or viral proteins into the VLP.[google.com]

    Missing: E1A associated
  • Nephronophthisis 4

    The organelles of human cells include: mitochondria, endoplasmic reti...[ncbi.nlm.nih.gov] Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2 . Proc. Natl Acad. Sci. USA 98 , 9784–9789 (2001). 14.[nature.com] The NPHP4 gene encodes a 1,250-amino acid protein of unknown function that we named nephrocystin-4.[ncbi.nlm.nih.gov] Nephrol. (2000) [ Pubmed ] Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.[wikigenes.org]

    Missing: E1A associated
  • Diffuse Gastric Cancer

    An E-cadherin/p53 double-conditional knockout (DCKO) mouse line recapitulates human DGC morphologically and molecularly.[ncbi.nlm.nih.gov] We found a cytoplasmic localization of pRb2/p130 in cancer tissue samples, whereas, in normal counterparts, we observed the expected nuclear localization. pRb2/p130 cytoplasmic[ncbi.nlm.nih.gov] Our results disclose important proteins such as apolipoprotein B-100, S100 and 14-3-3 proteins, among many others, highlighting the different pathways enriched by each cancer[ncbi.nlm.nih.gov] These missense E-cadherin mutants result in full-length proteins which, when assayed in cell culture, still retain some biological activity.[ncbi.nlm.nih.gov]

    Missing: E1A associated
  • Progeria

    Register Progeria: a human-disease model of accelerated aging - 24 Hours access EUR 36.00 GBP 28.00 USD 45.00 Rental This article is also available for rental through DeepDyve[doi.org] Depletion of lamins compromises HR by a mechanism involving transcriptional downregulation of BRCA1 and RAD51 by the repressor complex formed by the Rb family member p130[doi.org] This concept led to the hypothesis that protein farnesyltransferase inhibitors (FTIs) might ameliorate the disease phenotypes of progeria in mouse models.[ncbi.nlm.nih.gov] Dmel\ Lam shares 36% identity and 57% similarity with human LMNB2, 37% identity and 60% similarity with human LMNA, and 37% identity and 59% similarity with human LMNB1.[flybase.org]

    Missing: E1A associated
  • Atypical Teratoid Rhabdoid Tumor

    Even though no increased recurrence rate seems to be reported in patients with brain tumors receiving recombinant human growth hormone (rhGH) replacement, in some patients[ncbi.nlm.nih.gov] For example, it has been established that overexpression of cyclin D1 will lead to hyperphosphorylation and inactivation of Rb family members that include Rb, p107 and p130[doi.org] This case emphasizes the importance of immunostaining for INI1 protein for distinguishing CPC from AT/RT in cases with atypical or indeterminate features.[ncbi.nlm.nih.gov] OBJECTIVE: This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like[ncbi.nlm.nih.gov]