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679 Possible Causes for ENDOPEPTIDASES

  • Urinary Tract Infection

    An endopeptidase involved in the cleavage of a variety of substrates, including collagen and extracellular matrix components.[doi.org]

  • Acute Bronchitis

    […] mediators in response to toxic, infectious, and inflammatory stimuli, in addition to decreased release of regulatory products such as angiotensin-converting enzyme or neutral endopeptidase[emedicine.medscape.com]

  • Dementia

    These include inhibitors of beta-secretase (the second endopeptidase involved in Aβ cleavage from its precursor protein), considered by some to be the most promising target[doi.org]

  • Osteoporosis

    The role of glutenases (propyl endopeptidases) and tight junction regulators ( table 5 ) are likely to be in reducing the threshold response and optimising the benefits of[doi.org]

  • Infectious Mononucleosis

    KRTHB3 (basic keratin 3), MUC2 (mucin 2), and PCOLN3 (type III procollagen N-endopeptidase) all have altered expression in EBV-associated gastric carcinomas [ 31 ].[dx.doi.org]

  • Idiopathic Pulmonary Fibrosis

    Regulation of endopeptidase activity was compromised to enhance cell surface receptor signaling and cell adhesion as a result of crosstalk between Wnt signaling pathway and[nature.com] For “molecular function”, peptidase inhibitor activity (12 proteins), peptidase regulator activity (12 proteins) and endopeptidase inhibitor activity (11 proteins) were the[journals.plos.org]

  • X-Linked Hypophosphatemia

    Given that PHEX has homology to endopeptidases, we propose that PHEX may have a role in the normal regulation of PTH.[ncbi.nlm.nih.gov] PHEX encodes an endopeptidase that, when inactivated, results in elevated circulating levels of FGF-23, a novel phosphate-regulating hormone (a phosphatonin), thereby resulting[ncbi.nlm.nih.gov] […] bone disease characterized biochemically by selective renal phosphate (Pi) wasting, is associated with mutations in the PEX (Phosphate-regulating gene with homologies to Endopeptidases[ncbi.nlm.nih.gov]

  • Hypophosphatemic Rickets

    Abstract Mutations in the phosphate-regulating endopeptidase homolog, X-linked, gene (PHEX), which encodes a zinc-dependent endopeptidase that is involved in bone mineralization[ncbi.nlm.nih.gov] The PHEX gene encodes an endopeptidase that is involved in phosphate regulation.[ncbi.nlm.nih.gov] Activating mutations of the fibroblast growth factor 23 (FGF-23) gene and inactivating mutations in the phosphate regulating gene (PHEX gene with homologies to endopeptidases[ncbi.nlm.nih.gov]

  • Distal Arthrogryposis Type 5D

    ECEL1 is a neuronal endopeptidase predominantly expressed in the central nervous system and brain structures during fetal life in mice and human.[readbyqxmd.com] ECEL1 encodes a neuronal endopeptidase and is expressed in the brain and peripheral nerves.[uthealth.influuent.utsystem.edu]

  • Familial Hypophosphatemia

    Key elements central to the pathophysiology of XLH and its related disorders are discussed, including the putative function of the mutated endopeptidase PHEX.[indiana.pure.elsevier.com] (XLH) is a rare genetic disorder resulting from excess circulating fibroblast growth factor (FGF) 23, secondary to loss-of-function PHEX mutations (phosphate-regulating endopeptidase[ultrarareadvocacy.com] This gene encodes an endopeptidase, predominantly expressed in osteoblast and odontoblast, whose only known natural substrate is parathyroid hormone-related peptide [Boileau[karger.com]

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