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679 Possible Causes for ENDOPEPTIDASES

  • Urinary Tract Infection

    An endopeptidase involved in the cleavage of a variety of substrates, including collagen and extracellular matrix components.[]

  • Acute Bronchitis

    […] mediators in response to toxic, infectious, and inflammatory stimuli, in addition to decreased release of regulatory products such as angiotensin-converting enzyme or neutral endopeptidase[]

  • Dementia

    These include inhibitors of beta-secretase (the second endopeptidase involved in Aβ cleavage from its precursor protein), considered by some to be the most promising target[]

  • Osteoporosis

    The role of glutenases (propyl endopeptidases) and tight junction regulators ( table 5 ) are likely to be in reducing the threshold response and optimising the benefits of[]

  • Infectious Mononucleosis

    KRTHB3 (basic keratin 3), MUC2 (mucin 2), and PCOLN3 (type III procollagen N-endopeptidase) all have altered expression in EBV-associated gastric carcinomas [ 31 ].[]

  • Idiopathic Pulmonary Fibrosis

    Regulation of endopeptidase activity was compromised to enhance cell surface receptor signaling and cell adhesion as a result of crosstalk between Wnt signaling pathway and[] For “molecular function”, peptidase inhibitor activity (12 proteins), peptidase regulator activity (12 proteins) and endopeptidase inhibitor activity (11 proteins) were the[]

  • X-Linked Hypophosphatemia

    Given that PHEX has homology to endopeptidases, we propose that PHEX may have a role in the normal regulation of PTH.[] PHEX encodes an endopeptidase that, when inactivated, results in elevated circulating levels of FGF-23, a novel phosphate-regulating hormone (a phosphatonin), thereby resulting[] […] bone disease characterized biochemically by selective renal phosphate (Pi) wasting, is associated with mutations in the PEX (Phosphate-regulating gene with homologies to Endopeptidases[]

  • Hypophosphatemic Rickets

    Abstract Mutations in the phosphate-regulating endopeptidase homolog, X-linked, gene (PHEX), which encodes a zinc-dependent endopeptidase that is involved in bone mineralization[] The PHEX gene encodes an endopeptidase that is involved in phosphate regulation.[] Activating mutations of the fibroblast growth factor 23 (FGF-23) gene and inactivating mutations in the phosphate regulating gene (PHEX gene with homologies to endopeptidases[]

  • Distal Arthrogryposis Type 5D

    ECEL1 is a neuronal endopeptidase predominantly expressed in the central nervous system and brain structures during fetal life in mice and human.[] ECEL1 encodes a neuronal endopeptidase and is expressed in the brain and peripheral nerves.[]

  • Familial Hypophosphatemia

    Key elements central to the pathophysiology of XLH and its related disorders are discussed, including the putative function of the mutated endopeptidase PHEX.[] (XLH) is a rare genetic disorder resulting from excess circulating fibroblast growth factor (FGF) 23, secondary to loss-of-function PHEX mutations (phosphate-regulating endopeptidase[] This gene encodes an endopeptidase, predominantly expressed in osteoblast and odontoblast, whose only known natural substrate is parathyroid hormone-related peptide [Boileau[]

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