Create issue ticket

237 Possible Causes for ETV6

Show results in: 日本語

  • B-Precursor Acute Lymphoblastic Leukemia

    ETV6-ABL1 fusion transcript was identified by whole transcriptome sequencing and confirmed by RT-PCR.[ncbi.nlm.nih.gov] […] the third showed the fusion gene duplicated and loss of the normal ETV6 allele.[ncbi.nlm.nih.gov] Abstract The ETV6/RUNX1 rearrangement is found in 20-30% of children with B-cell precursor acute lymphoblastic leukemia and is associated with a good outcome.[ncbi.nlm.nih.gov]

  • Childhood Acute Lymphoblastic Leukemia

    A frequent concomitant event is the loss of the residual ETV6 allele suggesting a critical role for the ETV6 transcriptional repressor in the etiology of this cancer.[ncbi.nlm.nih.gov] Aberrations identified in this case involve both chromosomes 12 and include not only the ETV6-AML1 gene fusion and two different microdeletions of ETV6 but also the hemizygous[ncbi.nlm.nih.gov] KEYWORDS: ETV6/RUNX1; childhood acute lymphoblastic leukemia; initiation; mechanisms; relapse[ncbi.nlm.nih.gov]

  • Congenital Mesoblastic Nephroma

    We report ETV6-NTRK3 fusion transcripts and/or ETV6-region rearrangement in five of six CMNs and in five of five CFSs.[ncbi.nlm.nih.gov] A specific ETV6-NTRK3 fusion-gene product is reported in association with the cellular variant.[ncbi.nlm.nih.gov] FISH analysis using a chromosome 11-centromere probe detected trisomy or tetrasomy 11 in all three tumors with the ETV6-NTRK3 fusion signal.[ncbi.nlm.nih.gov]

  • Myeloid Neoplasm Associated with PDGFRB Rearrangement

    […] with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 that is characterized by the rearrangement of the PDGFRB gene, most often resulting in the formation of ETV6[malacards.org] […] in Hematology , 2016 , 2016 , 1 CrossRef 8 Prasad Koduru , Naga Guruju , Prapti Patel , Jiadi Wen , Kathleen Wilson , Sara Monaghan , A unique rearrangement of PDGFRα and ETV6[onlinelibrary.wiley.com] PDGFRB, ETV6, ETV6-PDGFRB rearrangement, Eosinophilic leukemia, Myeloid neoplasm The upper limit of normal range of eosinophils in the peripheral blood is an absolute eosinophil[clinmedjournals.org]

  • Myeloid Neoplasm Associated with FGFR1 Rearrangement

    1998;92:1735 ) 8p11 may also involve MOZ gene, a putative histone acetyltransferase, associated with AML-M4 / M5 ( Blood 1997;90:3130 ) t(5;12)(q33;p13) creating PDGFRB and ETV6[pathologyoutlines.com] […] in Hematology , 2016 , 2016 , 1 CrossRef 8 Prasad Koduru , Naga Guruju , Prapti Patel , Jiadi Wen , Kathleen Wilson , Sara Monaghan , A unique rearrangement of PDGFRα and ETV6[onlinelibrary.wiley.com] PDGFRB, ETV6, ETV6-PDGFRB rearrangement, Eosinophilic leukemia, Myeloid neoplasm The upper limit of normal range of eosinophils in the peripheral blood is an absolute eosinophil[clinmedjournals.org]

  • Fibrosarcoma

    […] a case of refractory IFS with constitutive activation of the tropomyosin-related kinase (TRK) signaling pathway from an ETS variant gene 6-neurotrophin 3 receptor gene (ETV6[ncbi.nlm.nih.gov] Molecular studies for the ETV6-NTRK3 translocation were negative in the three cases tested.[ncbi.nlm.nih.gov] Infantile fibrosarcoma (IFS) is a malignant neoplasm, arising in children younger than 2 years of age and with a hallmark chromosomal translocation t(12;15)(p13;q26) encoding an ETV6[ncbi.nlm.nih.gov]

  • Hypereosinophilic Syndrome

    RT-PCR of the aspirate revealed the presence of transcripts of ETV6/PDGFR-beta t(5;12) gene fusion.[ncbi.nlm.nih.gov] ETV6-ABL1 fusion gene The ETV6-ABL1 fusion gene results from a t(9;12)(q34;p13) or complex rearrangements. 90 - 93 Importantly, the creation of the ETV6-ABL1 fusion requires[doi.org] […] abnormalities that have been described in chronic eosinophilic leukemia include t(5:12) and t(8:13), and molecular genetic abnormalities include the FIP1L1-PDGFRA fusion gene and ETV6[emedicine.medscape.com]

  • Autosomal Dominant Thrombocytopenia 5

    We identified 20 ETV6 -RT patients from 7 pedigrees.[haematologica.org] Preliminary data (Table 1) show that mutations of RUNX1 ETV6 gene are present only in the group of myelodysplastic thrombocytopenic.[paduaresearch.cab.unipd.it] […] as thrombocytopenia 5 with increased susceptibility to malignancy , and has symptoms including petechiae of skin An important gene associated with Thrombocytopenia 5 is ETV6[malacards.org]

  • Acute Lymphoblastic Leukemia

    […] for the ETV6 gene.[ncbi.nlm.nih.gov] 1.8%) than those without ETV6-RUNX1 .[doi.org] Kinase Mutations in ALL; 4.3.3.3 DUX4 and ERG-Deregulated ALL; 4.3.3.4 Translocations Involving the IGH Locus; 4.3.3.5 PAX5 Rearrangements; MEF2D and ZNF384 Gene Fusions; ETV6[worldcat.org]

  • T-cell Acute Lymphoblastic Leukemia

    […] transformation using a mouse models of mutant ETV6 induced T-ALL.[grantome.com] BACKGROUND: The role of ETV6 in B-cell acute lymphoblastic leukemia (ALL) has been extensively studied, whereas only rare cases of ETV6 involvement in pediatric T-cell ALL[ncbi.nlm.nih.gov] WT1, ETV6, JAK1, JAK3, and RUNX1, were present, while CDKN2A/B deletions/mutations were never detected.[ncbi.nlm.nih.gov]

Further symptoms