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9,008 Possible Causes for Enzymologic, Expression, Gene, Regulation

  • T-cell Acute Lymphoblastic Leukemia

    Factor/metabolism* Mice Mice, Inbred NOD Mice, SCID MicroRNAs/metabolism* Middle Aged PTEN Phosphohydrolase/metabolism* Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/enzymology[ncbi.nlm.nih.gov] Our results suggest that miR-146b-5p is a functionally relevant microRNA gene in the context of T-ALL, whose negative regulation by TAL1 and possibly other oncogenes contributes[ncbi.nlm.nih.gov] KEYWORDS: T-ALL; ZBTB16-ABL1; fusion gene; gene mutation; transcriptome[ncbi.nlm.nih.gov] KEYWORDS: Copy number variation; Droplet digital PCR; Gene expression profiling; Mutations; T-ALL; TCRγδ T-ALL[ncbi.nlm.nih.gov]

  • Insulin-Like Growth Factor I

    IGF-1, IGF-2 C — CHEMISTRY; METALLURGY C12 — BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING C12N — MICROORGANISMS OR[google.tm] Growth hormone (GH) plays an essential role in controlling somatic growth and in regulating multiple physiological processes in humans and other species.[ncbi.nlm.nih.gov] The tumor cells expressed IGF-II and transforming growth factor alpha, but not IGF-I mRNA.[ncbi.nlm.nih.gov] These observations provide a partial explanation for the mechanism by which IGF-I controls nutrient supply in the regulation of fetal growth.[ncbi.nlm.nih.gov]

  • Influenza

    Methods in enzymology. 2003;363:489–98. pmid:14579598. View Article PubMed/NCBI Google Scholar 71.[doi.org] Romagnani S (2006) Regulation of the T cell response . Clin Exp Allergy 36 : 1357–1366 35.[nature.com] […] into the human virus gene pool.[pubmedcentral.nih.gov] Expression of KLRD1 was inversely correlated with symptom severity.[ncbi.nlm.nih.gov]

  • Polyploidy

    In particular, although relatively little is known about the enzymology of cell-wall metabolism, more than 420 genes could be assigned probable roles in pathways responsible[doi.org] Abstract Polyploidy has been reported in several animal cells, as well as within humans; however the mechanism of developmental regulation of this process remains poorly understood[ncbi.nlm.nih.gov] Combining gene order and gene duplication data assigns essentially the whole genome into sister regions, the largest gap being only 36 genes long.[doi.org] Compared to their parental cells, the resulting Tbx2-expressing cells are larger, with binucleate and lobular nuclei containing double the number of chromosomes.[ncbi.nlm.nih.gov]

  • Candida Albicans

    , Otolaryngol Head Neck Surg , 1999 , vol. 120 (pg. 621 - 7 ) 7 Detection of prosthetic joint biofilm infection using immunological and molecular techniques , Methods in enzymology[doi.org] These include guides that are allele- and gene-specific and those that could target multiple genes or gene families.[doi.org] Strains are engineered to over-express a specific gene and the resulting gain-of-function phenotype assessed.[doi.org] These strains produce a heterodimeric repressor, a1-alpha2, which suppresses switching to the opaque phase by inhibiting expression of the master regulator Wor1.[ncbi.nlm.nih.gov]

  • Listeria Monocytogenes

    […] e.g. primers or probes for detection or identification of organisms for bacteria C — CHEMISTRY; METALLURGY C12 — BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY[patents.google.com] VirR thus appears to control virulence by a global regulation of surface components modifications.[ncbi.nlm.nih.gov] In contrast, ammonia, which is the most abundant nitrogen source in soil and water, fully supports growth, but fails to activate virulence gene transcription.[ncbi.nlm.nih.gov] Expression in Escherichia coli and sequence analysis of the listeriolysin O determinant of Listeria monocytogenes.[ncbi.nlm.nih.gov]

  • Lafora Disease

    Animals Blotting, Western COS Cells Catalytic Domain Cell Line Cytoplasm/metabolism DNA, Complementary/metabolism Gene Library Glycogen/metabolism* Humans Lafora Disease/enzymology[ncbi.nlm.nih.gov] Laforin regulates autophagy via the mammalian target of rapamycin kinase-dependent pathway.[ncbi.nlm.nih.gov] The critical region for the Lafora gene has been localised to chromosome 6q24 flanked by the dinucleotide repeat markers D6S292 and D6S420.[ncbi.nlm.nih.gov] Neuronatin is highly expressed in human fetal brain with gradual decrease in expression in developing and adult brain.[ncbi.nlm.nih.gov]

  • Cornelia De Lange Syndrome

    Enzymological, biophysical, and structural studies of CdLS HDAC8 protein mutants have yielded critical insight on compromised catalysis in vitro.[ncbi.nlm.nih.gov] Mutations in core cohesin subunits SMC1A, SMC3 and RAD21, or their regulators NIPBL and HDAC8, cause Cornelia de Lange syndrome (CdLS).[ncbi.nlm.nih.gov] Our findings suggest a dynamic model where NIPBL loads cohesin to connect genes in communities, offering an explanation for the gene expression deregulation in the CdLS.[ncbi.nlm.nih.gov] KEYWORDS: Cornelia de Lange syndrome; SMC1A; differential allelic expression; pyrosequencing; sex-related gene expression[ncbi.nlm.nih.gov]

  • Saccharomyces Cerevisiae

    CBS from Saccharomyces cerevisiae (yCBS) naturally lacks the heme-containing N-terminal domain, which makes it an ideal model for spectroscopic studies of the enzymological[ncbi.nlm.nih.gov] Further our work suggests that NuA4 regulates acetyl-CoA levels through the Acetyl-CoA carboxylase Acc1.[ncbi.nlm.nih.gov] We identified most known oxygen-regulated genes and also uncovered new regulated genes.[ncbi.nlm.nih.gov] However, mammalian membrane proteins, many of which are important therapeutic targets, are too unstable to be expressed in heterologous hosts and to be solubilized by detergents[ncbi.nlm.nih.gov]

  • Primary Effusion Lymphoma

    […] terms Amino Acid Sequence Base Sequence Cell Line, Tumor Exons Herpesvirus 8, Human/genetics* High-Throughput Nucleotide Sequencing/methods Humans Lymphoma, Primary Effusion/enzymology[ncbi.nlm.nih.gov] Moreover, dhC16-Cer up-regulation of THBS1 was through the suppression of multiple KSHV microRNAs expression.[ncbi.nlm.nih.gov] Here we used gene expression profile analysis to determine the viral impact on cellular gene expression and the pathogenesis of these lymphomatous effusions.[ncbi.nlm.nih.gov] Gov't MeSH terms Animals Apoptosis/drug effects Cell Line, Tumor Enzyme Inhibitors/pharmacology Humans Lymphoma, Primary Effusion/drug therapy* Lymphoma, Primary Effusion/enzymology[ncbi.nlm.nih.gov]