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11,006 Possible Causes for FAMILY,, H2A, HISTONE, M, MEMBER

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  • Streptococcus Pyogenes

    CTH contain the core histones H2A, H2B, H3, H4 and subtypes of the linker histone H1.[karger.com] We report the details of two epidemiologically unrelated patients with bacteraemia featuring M-type 58 Streptococcus pyogenes, a seemingly rare cause of human infection in[ncbi.nlm.nih.gov] This first report of a family outbreak due to emm11 S. pyogenes reinforces the importance of surveillance of close family contacts of individuals with invasive streptococcal[ncbi.nlm.nih.gov] Histones are small basic proteins and highly conserved among eukaryotes.[ncbi.nlm.nih.gov] We found a 2:1 (m/m) binding stoichiometry of K2 hPg /VKK38, with the lysine-binding sites of two K2 hPg domains anchored to two regions of monomeric VKK38.[ncbi.nlm.nih.gov]

  • Procainamide

    EXPERIMENTAL DESIGN: MDA-231, MCF-7, and T24 cell lines were treated for 5 days with 10 micro M hydralazine or 10 micro M procainamide. 5-aza-deoxycytidine at 0.75 micro M[ncbi.nlm.nih.gov] OBJECTIVE: Procainamide related autoimmunity is characterized by the production of antibodies to histones and, in particular, to the H2A-2B dimer.[ncbi.nlm.nih.gov] Of 55 family members (mean /-SD age, 27 /-17 years; 33 female), 9 additional affected family members were detected from 2 families, with a single Brugada syndrome patient[ncbi.nlm.nih.gov] 12 , Gardner M 13 , Simpson CS 14 .[ncbi.nlm.nih.gov] 10 mA); conduction velocity of the earliest premature beat (0.54 /- 0.06 ms vs 0.50 /- 0.06 ms, P 0.05); or wavelength of the earliest premature atrial beat (11.5 /- 1.6 m[ncbi.nlm.nih.gov]

  • Vincristine

    The effect of G2/M phase arrest was associated with the upregulation of cyclin B1 and downregulation of p-cdc2.[ncbi.nlm.nih.gov] […] cells co-treated with vincristine and XL019 resulted from the up-regulation of phosphorylated retinoblastoma protein (pRb), p21, and the DNA-damage protein, phosphorylated H2A[ncbi.nlm.nih.gov] A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated[ncbi.nlm.nih.gov] KEYWORDS: Cell cycle; drug resistance; histone deacetylase inhibitor; lymphoma; microtubule; mitosis; polyploidy[ncbi.nlm.nih.gov] In molecular docking simulation modeling, NVP-BSK805 showed higher binding affinity docking scores against a P-gp member (ABCB1) than CEP-33779 did.[ncbi.nlm.nih.gov]

  • Coal Tar

    The highest exposure levels measured were 12.8 mg/m(3) for total particulate, 1.9 mg/m(3) for coal tar pitch volatiles as BSF, and 12.8 microg/m(3) for B(a)P.[ncbi.nlm.nih.gov] Additional proteins with altered expression include histone H2A.1, heat-shock protein 70-2, galectin-3, nucleoside diphosphate kinase, ATP synthase, and electron transfer[ncbi.nlm.nih.gov] How to Protect Your Family • If your driveway has been sealed with coal tar, you can seal over it with asphalt to diminish your exposure, or have contractors safely blast[thedoctorstv.com] RA application also reduced basal levels of P4501A2 (another P4501A1 subfamily member) mRNA by 93% (n 7, P 0.001) as determined by reverse transcription-polymerase chain reaction[ncbi.nlm.nih.gov] […] inflammation and itchiness associated with these diseases, and coal tar soap can help slow down rapid skin cell growth seen in seborrheic dermatitis, according to the American Family[livestrong.com]

  • Intrahepatic Cholangiocarcinoma

    High expression of H2A histone family member Z (H2A.Z) is a high-risk factor for poor prognosis in patients with breast cancer and primary hepatocellular cancer.[ncbi.nlm.nih.gov] Akatsu T 1 , Shimazu M , Shinoda M , Kawachi S , Tanabe M , Aiura K , Ueda M , Kameyama K , Sakamoto M , Kitajima M , Kitagawa Y .[ncbi.nlm.nih.gov] The patient also had a strong family history of cancer.[ncbi.nlm.nih.gov] Kumamoto T 1 , Tanaka K , Takeda K , Nojiri K , Mori R , Taniguchi K , Matsuyama R , Ueda M , Sugita M , Ichikawa Y , Nagashima Y , Endo I .[ncbi.nlm.nih.gov] Abstract Integrin subunit alpha 3 (ITGA3) interacts with a beta 1 subunit to form a member of the integrin family.[ncbi.nlm.nih.gov]

  • Pentamidine

    Martin, M. A., Cox, P. H., Beck, K., Styer, C. M., Beall, G. N.[link.springer.com] Pentamidine was found to inhibit the acetylation of histone H2A which could contribute both to inhibition of IR-induced focus formation and HR repair.[ncbi.nlm.nih.gov] Pentamidine treatment results in chromosomal segregation defects and delayed progression through mitosis, consistent with inhibition of the phosphatase of regenerating liver family[ncbi.nlm.nih.gov] We propose that pentamidine is the founding member of a novel pharmacological entity whose members act as small molecule antichaperones.[ncbi.nlm.nih.gov] The human S100 protein family contains small, dimeric and acidic proteins that contain two EF-hand motifs and bind calcium.[ncbi.nlm.nih.gov]

  • Lisinopril

    Collaborators (21) Ito H , Yoshikawa N , Kawamura T , Sasaki S , Hoshii S , Kawamura K , Igarashi T , Awazu M , Honda M , Ikeda M , Hataya H , Ishikura K , Ito S , Nakanishi[ncbi.nlm.nih.gov] Our patient had negative results on ANA testing and had histone antibodies (IgG anti-[H2A-H2B]-DNA) mirroring the disease course.[ncbi.nlm.nih.gov] “By this time other family members were arriving and for two weeks I don’t remember anything other than what I was later told by family and doctors.[peoplespharmacy.com] […] retrospective study was conducted using a health insurance claims database spanning the period from January 1997 through December 2003 and representing approximately 40 million members[ncbi.nlm.nih.gov] We advance the profession of pharmacy for public and patient benefit, to improve the health of the public and to secure the future of our members.[medicinescomplete.com]

  • Autoimmune Disease

    To quantify the biochemical basis for JAK isozyme selectivity, we determined that the apparent K m value for each JAK isozyme ranged from 31.8 to 2.9 μ M for JAK1 and JAK3[ncbi.nlm.nih.gov] These and H2A/H2B-modifications constitute the so called histone code.[diarect.com] This study was conducted in an American family segregating autosomal dominant LFSNHL.[ncbi.nlm.nih.gov] Although both BD1 and BD2 bind acetylated histone residues, they may independently regulate the expression of BET-sensitive genes.[ncbi.nlm.nih.gov] The observation of immune dysregulation polyendocrinopathy enteropathy X-linked syndrome and multiorgan endocrine autoimmune phenomena in various members of one family, associated[ncbi.nlm.nih.gov]

  • Ataxia Telangiectasia

    Abstract Ataxia-telangiectasia (AT) and hyper-immunoglobulin M (HIGM) syndrome are both primary immunodeficiency diseases caused by different genetic defects.[ncbi.nlm.nih.gov] […] transcriptional coactivator and phosphatase 1 5 4,275,728 4,495,525 RGD:8661242 G Eya3 EYA transcriptional coactivator and phosphatase 3 5 150,833,754 150,915,390 RGD:8661242 G H2afx H2A[rgd.mcw.edu] TL measurement alone is not a good marker for predicting cancer risk in A-T families. The Author 2017. Published by Oxford University Press.[ncbi.nlm.nih.gov] KEYWORDS: Cpn10; NPAT; cell cycle; cell proliferation; cyclin; heat shock protein (HSP); histone; histone transcription[ncbi.nlm.nih.gov] member credentials (e-mail or 6-digit Member ID number) Non-AAN Member Subscribers : Sign in with subscriber credentials Log in using your username and password You May Also[cp.neurology.org]

  • Timolol

    Study Coordinator: M. Sederholm.[nejm.org] Antinuclear antibodies in a homogenous pattern, and markedly elevated histone antibodies (IgG anti-(H2A-H2B)-DNA) were present while antibodies to native DNA were absent.[ncbi.nlm.nih.gov] His heart rate was about half its normal rate, an ECG revealed sinus bradycardia, and it was determined he had significant cardiac issues in his family history.[ncbi.nlm.nih.gov] We advance the profession of pharmacy for public and patient benefit, to improve the health of the public and to secure the future of our members.[medicinescomplete.com] Health Professional Lisa Nelson RD provides step-by-step guidance to lower cholesterol and lower blood pressure, so you live life and enjoy your family for years to come.[healthcentral.com]