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10,080 Possible Causes for FAMILY,, H2A, HISTONE, MEMBER, Q

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  • Procainamide

    Cardiotoxicity associated with these levels included progressive widening of the QRS and corrected Q-T intervals, induction of polymorphic non-sustained ventricular tachycardia[ncbi.nlm.nih.gov] Procainamide related autoimmunity is characterized by the production of antibodies to histones and, in particular, to the H2A-2B dimer.[ncbi.nlm.nih.gov] Of 55 family members (mean /-SD age, 27 /-17 years; 33 female), 9 additional affected family members were detected from 2 families, with a single Brugada syndrome patient[ncbi.nlm.nih.gov] Q. How is procainamide supplied? A.[journals.lww.com] It is especially important to listen to patient and family cues.[ncbi.nlm.nih.gov]

  • Retinoblastoma

    Q&A with NAES The National Artificial Eye Service, part of the NHS, makes up to 5,000 bespoke artificial eyes a year for people of all ages, from babies to pensioners.[chect.org.uk] Our study identified stress response proteins to be hyperphosphorylated in RB which included H2A histone family member X (H2AFX) and sirtuin 1.[ncbi.nlm.nih.gov] Here, we present the first case of familial RB caused by a de novo insertion of a full-length long interspersed element-1 (LINE-1) into intron 14 of the RB1 gene that caused[ncbi.nlm.nih.gov] Being 23.5 kDa monomers, which itself is not common for the DNApolβ superfamily members, these chromatin associated proteins manifests most of the DNApolβ-specifc functional[ncbi.nlm.nih.gov] We analyzed the role of the retinoblastoma gene family in regulating senescence in mice and humans.[ncbi.nlm.nih.gov]

  • Pentamidine

    Coxiella burnetii is the bacterial agent of Q fever in humans. Acute Q fever generally manifests as a flu-like illness and is typically self-resolving.[ncbi.nlm.nih.gov] Pentamidine was found to inhibit the acetylation of histone H2A which could contribute both to inhibition of IR-induced focus formation and HR repair.[ncbi.nlm.nih.gov] Pentamidine treatment results in chromosomal segregation defects and delayed progression through mitosis, consistent with inhibition of the phosphatase of regenerating liver family[ncbi.nlm.nih.gov] We propose that pentamidine is the founding member of a novel pharmacological entity whose members act as small molecule antichaperones.[ncbi.nlm.nih.gov] The human S100 protein family contains small, dimeric and acidic proteins that contain two EF-hand motifs and bind calcium.[ncbi.nlm.nih.gov]

  • Autoimmune Disease

    Q: Are autoimmune diseases inherited?[autoimmune.pathology.jhmi.edu] These and H2A/H2B-modifications constitute the so called histone code.[diarect.com] This study was conducted in an American family segregating autosomal dominant LFSNHL.[ncbi.nlm.nih.gov] Although both BD1 and BD2 bind acetylated histone residues, they may independently regulate the expression of BET-sensitive genes.[ncbi.nlm.nih.gov] Within 4 h, activation of CD4 T cells invokes changes in histone modifications and enhancer RNA transcription that correspond to altered expression of the interacting genes[ncbi.nlm.nih.gov]

  • Lisinopril

    Q: Does 40 mg of lisinopril make you sleepy?[everydayhealth.com] Our patient had negative results on ANA testing and had histone antibodies (IgG anti-[H2A-H2B]-DNA) mirroring the disease course.[ncbi.nlm.nih.gov] “By this time other family members were arriving and for two weeks I don’t remember anything other than what I was later told by family and doctors.[peoplespharmacy.com] […] retrospective study was conducted using a health insurance claims database spanning the period from January 1997 through December 2003 and representing approximately 40 million members[ncbi.nlm.nih.gov] We advance the profession of pharmacy for public and patient benefit, to improve the health of the public and to secure the future of our members.[medicinescomplete.com]

  • Ataxia Telangiectasia

    Fortman, MD, Justin Q. Ly, MD, Scot E. Campbell, MD, and Douglas P.[appliedradiology.com] […] transcriptional coactivator and phosphatase 1 5 4,275,728 4,495,525 RGD:8661242 G Eya3 EYA transcriptional coactivator and phosphatase 3 5 150,833,754 150,915,390 RGD:8661242 G H2afx H2A[rgd.mcw.edu] TL measurement alone is not a good marker for predicting cancer risk in A-T families.[ncbi.nlm.nih.gov] Precise modulation of histone gene transcription is critical for cell cycle progression.[ncbi.nlm.nih.gov] BK and JC are both members of the polyomavirus family.[ncbi.nlm.nih.gov]

  • Vincristine

    11 countries to investigate the addition of etoposide (100 mg/m2, days 1, 2 & 3) to a four-course induction of vincristine (1.5 mg/m2 10 wkly) and carboplatin (550 mg/m2 q[ncbi.nlm.nih.gov] […] cells co-treated with vincristine and XL019 resulted from the up-regulation of phosphorylated retinoblastoma protein (pRb), p21, and the DNA-damage protein, phosphorylated H2A[ncbi.nlm.nih.gov] A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is implicated[ncbi.nlm.nih.gov] Histone deacetylase inhibitors (HDACi) are novel therapeutics being clinically-evaluated in combination with a variety of other drugs.[ncbi.nlm.nih.gov] In molecular docking simulation modeling, NVP-BSK805 showed higher binding affinity docking scores against a P-gp member (ABCB1) than CEP-33779 did.[ncbi.nlm.nih.gov]

  • Streptococcus Pyogenes

    Therapie Milzbrand: Bacillus anthracis Morbus Whipple N Nocardiose (old) P Paratrachom Pertussis – Keuchhusten Pneumokokken (old) Pneumokokken Erkrankungen (old) Psittakose Q[meditricks.de] CTH contain the core histones H2A, H2B, H3, H4 and subtypes of the linker histone H1.[karger.com] This first report of a family outbreak due to emm11 S. pyogenes reinforces the importance of surveillance of close family contacts of individuals with invasive streptococcal[ncbi.nlm.nih.gov] Histones are small basic proteins and highly conserved among eukaryotes.[ncbi.nlm.nih.gov] The copy number of a specific cDNA was calculated using the Rotor-Gene Q MDx instrument and the Rotor-Gene SYBR Green PCR kit (Qiagen).[frontiersin.org]

  • Coal Tar

    CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008.[ewg.org] Additional proteins with altered expression include histone H2A.1, heat-shock protein 70-2, galectin-3, nucleoside diphosphate kinase, ATP synthase, and electron transfer[ncbi.nlm.nih.gov] How to Protect Your Family • If your driveway has been sealed with coal tar, you can seal over it with asphalt to diminish your exposure, or have contractors safely blast[thedoctorstv.com] RA application also reduced basal levels of P4501A2 (another P4501A1 subfamily member) mRNA by 93% (n 7, P 0.001) as determined by reverse transcription-polymerase chain reaction[ncbi.nlm.nih.gov] Correll award from RCI, and the James Q. McCawley Award from the MRCA. Dick holds honorary memberships in both ASTM and RCI Inc.[buildings.com]

  • Diltiazem

    Leslie Ako-Mbo, PharmD Q: Can diltiazem cause you to retain fat?[everydayhealth.com] Antihistone antibodies are correlated with the ingestion of chlorpromazine and hydralazine, and antibodies to the histone–DNA complex (H2a–H2b–DNA) with the ingestion of procainamide[nejm.org] Diltiazem hydrochloride, a member of the calcium channel blocker family of antihypertensive medications, has been found to produce many cutaneous reactions, such as photodistributed[ncbi.nlm.nih.gov] The combination of diltiazem and lactacystin also up-regulated the levels of Bik and released Bak from Bcl-xL, indicating the involvement of the Bcl2 family pathway in this[ncbi.nlm.nih.gov] Several members of a family suffering from an apparent autosomal dominant form of primary focal hyperhidrosis had a marked reduction in sweat output with the use of the calcium[sweathelp.org]