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2,338 Possible Causes for Fusion, Oncogene, Proteins

Did you mean: Fusion, Oncogene, proteus

  • Ewing Family of Tumors

    We studied the expression of 4 tumor suppressor proteins in the Ewing family of tumors (EFTs).[] It leads to the formation of the EWS-FLI-1 oncogenic fusion protein and is present in 85% of ET patients.[] Molecular techniques used to identify this translocation along with the knowledge that the protein product of the MIC2 gene is highly expressed on the cell surface have greatly[]

  • Promiscuity

    Heterochromatin protein 1 (HP1) proteins were originally identified as critical components in heterochromatin-mediated gene silencing and are now recognized to play essential[] […] notable assortment of tumor types from different lineages, including hematolymphoid, mesenchymal, epithelial and neural tumors, through a variety of genetic mechanisms: gene fusions[] The protein molecule bound a single molecule of GCA, in contrast to the 1:2 stoichiometry observed with fatty acids.[]

  • Peripheral T-cell Lymphoma

    […] p-γH2AX and apoptosis proteins including cleaved-caspase-3, cleaved-caspase-9 and cleaved-PARP, and down-regulating anti-apoptosis protein Bcl-2.[] We also identified novel kinase gene fusions, ITK-FER and IKZF2-ERBB4, as candidate therapeutic targets that show similarities to known recurrent oncogenic ITK-SYK fusions[] […] of HRS-L cells in association with this composite lymphoma raises a possible link between their occurrence and DLBCLs in PTCLs; furthermore, the frequent detection of MYC protein[]

  • Diffuse Intrinsic Pontine Glioma

    Protein profiling identified 2,305 unique proteins indicating distinct DIPG protein expression patterns compared to other pediatric brain tumors.[] Structural variants generating fusion genes were found in 47% of DIPGs and NBS-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3[] The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies.[]

  • Sulindac

    ; isolated proteins and peptides were identified by nanoLC-MS-MS.[] Chromosomal translocations can lead to the formation of chimeric genes encoding fusion proteins such as PML/RARα, PLZF/RARα, and AML-1/ETO, which are able to induce and maintain[] We sought to investigate the influence of the thyroid oncogenes BRAFV600E, H-RASV12, and p110α (H1074R) on the regulation of the PI3K downstream target FOXO3 in vitro.[]

  • Herpes Simplex Virus 1

    During viral infection, accumulation of viral proteins can cause stress in the endoplasmic reticulum (ER) and trigger the unfolded protein response (UPR) to restore ER homeostasis[] HD10.6 cells proliferate by virtue of a transduced tetracycline-regulated v-myc oncogene.[] As uncontrolled fusion of the host membranes should be avoided in these events, tight regulation of the viral fusion machinery is critical.[]

  • T-cell Acute Lymphoblastic Leukemia

    Analysis of the effects of pan-PIM protein kinase inhibitors on human T-ALL cell lines demonstrated that the sensitive cell lines expressed higher PIM1 protein kinase levels[] Bubble PCR is a powerful tool for detecting unknown fusion transcripts as well as genomic fusion points.[] Many oncogenes and tumor suppressors in T-ALL are transcription factors that are required for normal hematopoiesis.[]

  • Soft Tissue Sarcoma

    The predictive value of serum C-reactive protein (CRP) and neutrophil/lymphocyte (N/L) ratio in soft tissue sarcoma (STS) patients receiving neoadjuvant radiotherapy (RT)[] It is well known that the treatment protocols for hematopoetic neoplasms carry a high risk of long-term oncogenicity.[] This report is novel in that to our knowledge, it is the first complete molecular characterization of an EWSR1-POU5F1 fusion in a soft tissue sarcoma.[]

  • Stress

    Yes-associated protein (YAP) is a powerful regulator and is overexpressed in many cancers, including HCC.[] To ascertain the anti-cancer effects of P. suffruticosa on oncogenic functions of PC and determine the detailed molecular mechanisms.[] […] of revision spinal fusion surgery.[]

  • Congenital Stationary Night Blindness

    This motif is important for protein-protein interactions and members of the LRR superfamily are involved in cell adhesion and axon guidance.[] Immunohistochemical and ultrastructural studies verified that fusion protein expression was limited to the DBC dendritic tips.[] Interestingly, the amino acid residue in transducin affected by the Nougaret mutation is in the position homologous to that affected by the oncogenic mutation originally reported[]