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46 Possible Causes for GLN20,, OROSOMUCOID, POLYMORPHISM,, VAL156

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  • Tacrolimus

    polymorphisms on tacrolimus level in CYP3A5 expressors and nonexpressors.[ncbi.nlm.nih.gov] Pharmacokinetics Tacrolimus is highly bound to plasma proteins (albumin) and erythrocytes (orosomucoid and hemoglobin), which are present in lower levels during pregnancy,[motherisk.org] OBJECTIVES: Because genetic polymorphisms cause diverse activity in drug metabolizing enzymes, drug concentrations in the blood may be variable among patients.[ncbi.nlm.nih.gov] Next, we investigated factors that could predict CYP3A5 polymorphism.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Warfarin

    We genotyped 201 warfarin-treated patients for common polymorphisms in VKORC1 and GGCX.[ncbi.nlm.nih.gov] The latter are encoded by ORM1 (orosomucoid 1 gene or alpha-1-acid glycoprotein 1 gene) and ORM2 (orosomucoid 2 gene or alpha-1-acid glycoprotein 2 gene). 16 , 17 It has been[nature.com] We genotyped 201 warfarin-treated patients for common polymorphisms in VKORC1 and GGCX .[doi.org] Genotyping of CYP2C9 and VKORC1 was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Lipoprotein Glomerulopathy

    ApoE2 polymorphism is well known for its relationship to type III hyperlipoproteinemia, and the common apoE2 isoform is encoded by the R158C allele.[ncbi.nlm.nih.gov] Staprans I, Felts JM (1977) The effect of α 1 -acid glycoprotein (orosomucoid) on triglyceride metabolism in nephrotic syndrome.[link.springer.com] ApoE polymorphisms including three common phenotypes (E2, E3, E4), and a variety of rare mutations can affect blood cholesterol and triglyceride levels.[ncbi.nlm.nih.gov] Lipoprotein (a) and apolipoprotein (a) in primary antiphospholipid syndrome New MspI polymorphism at 83 bp of the human apolipoprotein al gene: Association with increased[documentslide.com]

    Missing: GLN20 VAL156
  • Periodontitis

    CONCLUSION: The IL-13 -1112 polymorphism may be associated with susceptibility to periodontitis.[ncbi.nlm.nih.gov] Christine Poitou, Adrien Boillot, Cécile Ciangura, Sandrine Katsahian, Jean-Marc Lacorte, Sébastien Czernichow, Olivier Meilhac, Philippe Bouchard and Catherine Chaussain , Orosomucoid[doi.org] In the total analyses, COX2 -765G/C polymorphism had nonsignificant association on periodontitis risk in all models.[ncbi.nlm.nih.gov] The MeSH terms "Periapical Periodontitis," "Periapical Abscess," "Polymorphism, Genetic," and "Polymorphism, Single Nucleotide" were used.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Crohn's Disease

    Sanjeevi CB, Miller EN, Dabadghao P, et al. (2000) Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis.[doi.org] C-reactive protein and orosomucoid: These are markers of inflammation, and their levels correlate with how active the disease is.[emedicinehealth.com] We conclude that the difference in SLC11A1 promoter polymorphism plays no role in CD in Ashkenazi Jews.[ncbi.nlm.nih.gov] Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Nephrotic Syndrome

    Genotyping of TNF-α-G308A single nucleotide polymorphism was done using polymerase chain reaction-restriction fragment length polymorphism method, while of IL-6-G174C single[ncbi.nlm.nih.gov] Long-term stability of albumin, protein HC, immunoglobulin G, Kappa- and lambda-chain-immunoreactivity, orosomucoid, and alpha 1-antitrypsin in urine stored at 20 degrees[doi.org] Frequency of this polymorphism in exon 9 is 7.3% among Japanese.[ncbi.nlm.nih.gov] CONCLUSIONS: Here we report that only the G2677A polymorphism was associated to NS susceptibility and steroid resistance.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Maturity-Onset Diabetes of the Young

    Despite its biological inactivity, S487N polymorphism led in combination with E41X to a significant earlier manifestation of diabetes, whereas I27L polymorphism or increased[ncbi.nlm.nih.gov] Benkoel for assays of C-reactive protein, and orosomucoid and immunohistochemistry experiments, respectively; and the families involved in the study.[doi.org] AIMS: PAX4 R192H polymorphism was reported to be associated with maturity onset diabetes of the young (MODY) and early onset-age of type 2 diabetes (T2D).[ncbi.nlm.nih.gov] Evidence for linkage was found with restriction-fragment-length polymorphism loci that map to human chromosome 20.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Artemether

    P. falciparum polymorphisms in pfcrt 76, pfmdr1 86, 184 and 1246, and pfmrp1 876 and 1466 were analysed by PCR-RFLP and pyrosequencing.[ncbi.nlm.nih.gov] The C-reactive protein, procalcitonin, fibrinogen, orosomucoid and cytokine levels are raised in acute malaria.[doi.org] AS/AQ selected for mutant pfcrt/pfmdr1 polymorphisms and AL for wild-type pfcrt/pfmdr1 polymorphisms associated with altered drug susceptibility.[ncbi.nlm.nih.gov] No genetic polymorphisms associated with resistance to artemisinin were found.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Primaquine

    […] sensitivity of Thai P. falciparum isolates against three 8-aminoquinolines, PQ, TQ and sitamaquine (SQ), a related 8-aminoquinoline and assessed the importance of pfmdr1 polymorphism[ncbi.nlm.nih.gov] […] grapefruit juice increases its oral bioavailibity. [15] In blood, about 20% of circulating primaquine is protein-bound, with preferential binding to the acute phase protein orosomucoid[en.wikipedia.org] There is evidence that metabolites of primaquine formed by the cytochrome pathway are responsible for methemoglobin formation; a genetic polymorphism of cytochrome isoforms[ncbi.nlm.nih.gov] CYP 2D6 is highly polymorphic among various human populations adding further complexity to a comprehensive understanding of primaquine pharmacology.[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156
  • Respiratory Syncytial Virus Infection

    Abstract MICA/MICB gene polymorphisms are related to several cancers and infectious diseases, but there are no reports on the association between MICA/MICB gene polymorphisms[ncbi.nlm.nih.gov] Orosomucoid 1-like protein 3 (ORMDL3) has been reported to associate with virus-triggered recurrent wheezing and asthma in children.[ncbi.nlm.nih.gov] The study presented here identifies TLR4 polymorphisms and investigates the association of TLR4 genetic polymorphism with RSV infection in a Chinese infant patient population[ncbi.nlm.nih.gov] KEYWORDS: MICA alleles; MICB alleles; gene polymorphism; respiratory syncytial virus; respiratory tract infection[ncbi.nlm.nih.gov]

    Missing: GLN20 VAL156