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1,386 Possible Causes for GLY245CYS, TP53

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  • Cancer-Associated Retinopathy

    In addition, they were positive for NSE, Ki-67, and TP53.[ncbi.nlm.nih.gov] The point mutation of their TP53 gene (exon 156) was detected as well.[ncbi.nlm.nih.gov]

    Missing: GLY245CYS
  • Hematopoietic Stem Cell Transplantation

    It is also important to note that at the time of initial diagnosis with MM, he had no mutation of TP53 and MYC in FISH, but at a relapse with testicular plasmacytoma, some[ncbi.nlm.nih.gov]

    Missing: GLY245CYS
  • Grant Syndrome

    LFS occurs when a person is born with a mutation in a gene called TP53 .[lfsassociation.org] The TP53 gene plays a role in about half of all diagnosed cancers, so researching this gene may bring us one step closer to preventing or curing many types of cancer, not[lfsassociation.org]

    Missing: GLY245CYS
  • Neurocutaneous Melanocytosis

    Finally, three amino acid-changing germline variants were detected: homozygous TP53 p.P72R, heterozygous KIT p.M541L, and homozygous KDR (VEGFR2) p.Q472H.[ncbi.nlm.nih.gov] Finally, three amino acid-changing germline variants were detected: homozygous TP53 p.P72R, heterozygous KIT p.M541L, and homozygous KDR ( VEGFR2 ) p.Q472H.[ingentaconnect.com]

    Missing: GLY245CYS
  • Thalidomide

    In this study, seven polymorphisms in genes related to development (FGF8, FGF10, BMP4, SHH, TP53, TP63, and TP73) were analyzed in people with thalidomide embryopathy (TE)[ncbi.nlm.nih.gov]

    Missing: GLY245CYS
  • Ovarian Cystic Teratoma

    Mutation in TP53 was associated with improved overall survival. In 8 of 20 cases with TP53 mutations, two or more variants were identified, which were bi-allelic.[clincancerres.aacrjournals.org] Conclusions: Ovarian SCC arising in MCT has a high mutational burden, with TP53 mutation the most common abnormality.[clincancerres.aacrjournals.org] The presence of TP53 mutation is a good prognostic factor. SCC arising in MCT share similar mutation profiles to other SCC.[clincancerres.aacrjournals.org]

    Missing: GLY245CYS
  • Propofol

    Finally, TP53 was proven to be target of miR-374a in HepG2 cells.[ncbi.nlm.nih.gov] Besides, miR-374a affected propofol-treated HepG2 cells by targeting TP53.[ncbi.nlm.nih.gov]

    Missing: GLY245CYS
  • Quinacrine

    UM-SCC cell lines with wild-type TP53 genotype underexpressed TP53 mRNA and protein when compared with normal human keratinocytes or UM-SCC with mutant TP53.[ncbi.nlm.nih.gov] TP53 genotype, mRNA and protein expression, TP53-induced p21 expression, and TP53 DNA-binding and reporter gene function were determined in a panel of nine previously characterized[ncbi.nlm.nih.gov] Although doxorubicin failed to induce TP53 expression or functional activity, quinacrine induced TP53 mRNA and protein expression, increased TP53 reporter activity and p21[ncbi.nlm.nih.gov]

    Missing: GLY245CYS
  • Ophthalmoplegia

    […] inducible subunit M2B p53-inducible and ribonucleotide reductase small subunit 2-like ribonucleotide reductase M2 B (TP53 inducible) ribonucleotide reductase small subunit[ukgtn.nhs.uk] […] mitochondrial dynamin like GTPase optic atrophy 1 (autosomal dominant) optic atrophy 1 gene OPA1 FLJ12460 KIAA0567 LARGEG NPG NTG 605290 8140 ribonucleotide reductase regulatory TP53[ukgtn.nhs.uk]

    Missing: GLY245CYS
  • Mantle Cell Lymphoma

    In the univariate model, mutations of TP53 (11%) and NOTCH1 (4%), and deletions of TP53 (16%) and CDKN2A (20%), were significantly associated with inferior outcomes (together[ncbi.nlm.nih.gov] We studied 3 cases of leukemic, non-nodal MCL in which TP53, ATM, and/or 13q14 deletions were identified.[ncbi.nlm.nih.gov] Patients with highly proliferative MCL and those with TP53 mutations tend to respond poorly despite intensive cytotoxic therapies.[ncbi.nlm.nih.gov]

    Missing: GLY245CYS

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