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871 Possible Causes for GTPase, Rap, activity, of, upregulation

  • Cilostazol

    -1/Rap-1 and indirect activation by Epac-1/Rap-1/PI3Kγ, resulting in synergistically induced PGI2 synthesis.[ncbi.nlm.nih.gov] Based on these results, we conclude that cilostazol and probucol exhibit a synergistic effect on the activation of mitochondrial biogenesis via upregulation of HO-1, which[ncbi.nlm.nih.gov] Summarizing, cilostazol activated SIRT1 and inhibited NF-κB-mediated transcription, thereby suppressing the expression of HIF-1α and VEGF.[ncbi.nlm.nih.gov] Cilostazol also accelerated anagen induction by stimulating vessel formation and upregulating the levels of phosphorylated extracellular signal-regulated kinase, c-Jun N-terminal[ncbi.nlm.nih.gov] In conclusion, cilostazol upregulates autophagy by activating SIRT1-coupled P-LKB1/P-AMPKα and inhibiting mTOR activation, thereby decreasing Aβ accumulation.[ncbi.nlm.nih.gov]

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  • Fructose

    Read on to find out whether high fructose corn syrup deserves its bad rap and how it really compares with regular sugar. What is High Fructose Corn Syrup?[sparkpeople.com] ALDOA was upregulated in RCC samples and RCC cell lines (P[ncbi.nlm.nih.gov] IQ motif containing GTPase-activating protein 1 (IQGAP1) is a MAPK scaffold that directly regulates the activation of RAF, MEK, and ERK.[ncbi.nlm.nih.gov] Moreover fructose-induced inflammation in the liver also leads to increased intracellular cortisol via an upregulation of 11-B hydroxysteroid dehydrogenase type 1 causing[ncbi.nlm.nih.gov] Interestingly, the serum triglycerides were higher, suggesting that the TG exportation mechanisms were upregulated in the liver ( 9 ) Now there is some nuance to this triglyceride[sciencedrivennutrition.com]

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  • Mevalonate Kinase Deficiency

    Furthermore, while inhibition of Rho/Rac/Rap prenylation promoted the release of IL-1β, specific inhibition of Rab prenylation by NE10790 had no effect in human peripheral[ncbi.nlm.nih.gov] Finally, we show that pharmacological inactivation of RhoA boosts Rac1 activity, a small GTPase whose activity was earlier implied in MKD pathogenesis.[ncbi.nlm.nih.gov] It was hypothesized that upregulation of FPPS would confer resistance to bisphosphonates and this study showed that upregulated endogenous FPPS introduced bisphosphonate resistance[ethos.bl.uk] Interestingly, activated fibroblasts from MKD patients secrete more IL-1beta than fibroblasts from healthy donors.[ncbi.nlm.nih.gov] […] by these GTPases.[ncbi.nlm.nih.gov]

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  • Brucella Abortus

    The results suggested that this so-called toxin was given a bad rap.[sciencelife.uchospitals.edu] This study reveals a novel mechanism for asp24 upregulation in B. abortus mutants. Copyright 2014, American Society for Microbiology. All Rights Reserved.[ncbi.nlm.nih.gov] Herein, we discuss the mechanism of caspase-1 activation and IL-1β secretion in glial cells infected with B. abortus.[ncbi.nlm.nih.gov] These results indicate that rBCSP31 is a TLR2 and TLR4 agonist that induces cytokine production, upregulates macrophage function and induces the Th1 immune response.[ncbi.nlm.nih.gov] Instead, this activation is dependent on the RNase activity of inositol-requiring enzyme 1 (IRE1).[ncbi.nlm.nih.gov]

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  • Leukocyte Adhesion Deficiency Syndrome

    LAD have been reported and include normal expression, but dysfunctional CD11/CD18; E selectin/CD62E expressed, but cleaved and present only as soluble form; and defective Rap[mplnet.com] Recently, it has been shown that in vivo administration of interferon gamma (IFN-gamma) upregulates CD18 expression in normals and alters leukocyte trafficking.[clinicaltrials.gov] Both constitutive and chemokine-triggered activation of Rap1 were abolished in LAD lymphocytes despite normal chemokine signaling.[ncbi.nlm.nih.gov] "Cortactin regulates the activity of small GTPases and ICAM-1 clustering in endothelium: Implications for the formation of docking structures."[hoelzel-biotech.com] […] human umbilical vein endothelial cells, but have normal levels of L-selectin and CD11b/CD18 integrin, and adhere to and migrate across endothelium when CD11b/CD18 is activated[ncbi.nlm.nih.gov]

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  • Lesch Nyhan Syndrome

    On examination it was observed that the child's hand and feet were rapped with cloth. After removal of the cloth all the fingers of both hands were found to be missing.[jisppd.com] The lack of enzyme activity is reverted in virus transformed cells.[link.springer.com] PubMed CrossRef Google Scholar Saito Y, Ito M, Hanaoka S, Ohama E, Akaboshi S, Takashima S (1999) Dopamine receptor upregulation in Lesh-Nyhan syndrome: a postmortem study[link.springer.com] We also show a marked impairment in the activation of small GTPase RAP1 in the HPRT-deficient cells, as well as differences in cytoskeleton dynamics that lead to increased[ncbi.nlm.nih.gov] […] the continuously active 'respiratory centre'.[ncbi.nlm.nih.gov]

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  • Sunburn

    Tips Over-the-counter moisturizers get a bad rap when it comes to burns. Buy a water-based moisturizer and then place it in the fridge to cool.[wikihow.com] Together the data may have broad implications for the immunotherapeutic properties of vitamin D in skin homeostasis, and implicate arginase-1 upregulation as a previously[ncbi.nlm.nih.gov] We fit a time-series regression model of search activity and perform statistical tests on the resulting parameter estimates.[ncbi.nlm.nih.gov] UVR activates release of membrane fatty acids and upregulates their metabolism by cyclooxygenases (COX) and lipoxygenases (LOX) to different eicosanoids.[ncbi.nlm.nih.gov] From January 2002 through December 2013, a total of 19,172 incident cases of clinically significant sunburn were diagnosed among active component service members.[ncbi.nlm.nih.gov]

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  • Newcastle Disease

    Other pathways involved in the upregulated expression of TRAIL are yet to be identified.[ncbi.nlm.nih.gov] We found that Newcastle disease virus can induce inflammasome activation in the human macrophage-like cell line THP-1.[ncbi.nlm.nih.gov] Rac1 is a member of the Rho GTPases involved in the regulation of the cell migration and cell-cycle progression.[ncbi.nlm.nih.gov] NDV-induced SGs contained classic SG markers T-cell internal antigen (TIA)-1, Ras GTPase-activating protein-binding protein (G3BP)-1, eukaryotic initiation factors, and small[ncbi.nlm.nih.gov] Moreover, the involvement of the GTPase dynamin in NDV entry is shown as its specific inhibitor, dynasore, also impaired NDV fusion and infectivity.[ncbi.nlm.nih.gov]

    Missing: Rap of
  • Paroxysmal Kinesigenic Dyskinesia

    Ras is also activated downstream of receptor tyrosine kinases, whereas Rap isozymes are activated downstream of GPCRs.[qiagen.com] […] central and peripheral nervous system, some of which are neurotrophic, others neurotoxic. 8 The study provides evidence suggesting that vitamin B12 deficiency may result from upregulation[ndnr.com] Increased spontaneous brain activity in the cortical-basal ganglia circuitry, especially in the motor preparation areas, is a common pathophysiology in PKD.[ncbi.nlm.nih.gov] PKCepsilon upregulates voltage-dependent calcium channels in cultured astrocytes . Glia. 55 , 1437–48 (2007).[nature.com] Functional assay: PKC Kinase Activity Assay Kit (ab139437) Signal from active PKC with background signal subtracted (duplicates; /- SD).[abcam.com]

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  • Quinacrine

    Upregulated SP1 expression further increased BAX expression.[ncbi.nlm.nih.gov] activity of NF-κB in MCF-7 cells.[ncbi.nlm.nih.gov] The enlarged vacuoles containing quinacrine excluded cherry fluorescent protein; many vacuoles were lined with cherry fluorescent protein-conjugated Rab7, a GTPase associated[ncbi.nlm.nih.gov] […] arrest and apoptosis in the DLBCL cell lines SU‑DHL‑8 and OCI‑LY01, in a dose‑dependent manner, in addition to the downregulation of cyclin‑dependent kinase 4/6 and the upregulation[ncbi.nlm.nih.gov] The side chains of 14, 15, and 17 have not been previously associated with antiprion activity and are interesting leads for further optimization of antiprion activity.[ncbi.nlm.nih.gov]

    Missing: Rap of