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144 Possible Causes for Glycine,, N methyl N ((3alpha,5beta,7alpha,12alpha) 3,7,12 trihydroxy 24 oxocholan 24 yl)

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  • Chenodeoxycholic Acid

    Thus, B. intestinalis AM-1 possesses 7alpha-hydroxysteroid dehydrogenase (7alpha-HSDH) activity.[ncbi.nlm.nih.gov] […] with a 3-oxo-7 alpha-hydroxy-delta 4-ring structure.[ncbi.nlm.nih.gov] Incubation of cholic acid with human hepatic microsomes and NADPH produced a single metabolite, 7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic (3-dehydrocholic) acid.[ncbi.nlm.nih.gov] […] conjugate Description Chenodeoxycholic acid glycine conjugate is an acyl glycine and a bile acid-glycine conugate.[foodb.ca] The patient was homozygous for a mutation (c.1249C T) in CYP7B1 that alters a highly conserved residue in oxysterol 7 α-hydroxylase (p.R417C) - previously reported in a family[ncbi.nlm.nih.gov] […] spectrometric (LC-ESI-MS/MS) method for the quantification of chenodeoxycholic acid (CDCA) and glycochenodeoxycholic acid (GCDCA), representative primary non-amidated and glycine-conjugated[ncbi.nlm.nih.gov] Structure Synonyms 3alpha,7alpha-Dihydroxy-5beta-cholanic acid 7α-hydroxylithocholic acid Acide chenodeoxycholique Acido chenodeoxicholico Acidum chenodeoxycholicum Anthropodeoxycholic[drugbank.ca]

    Missing: N methyl N ((3alpha 12 trihydroxy 24 oxocholan 24 yl)
  • Bile Salt

    -3-one GCCA AKR1C4 LCHA H2O NADP CH25H CYP8B1 AKR1C2 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one CoA-SH ATP RXRA bile salts 5beta-cholestan-7alpha,12alpha,27-triol-3-[wikipathways.org] Here, we characterize the nature of this antibody response in 7 more patients with antibody-induced BSEP deficiency (AIBD).[ncbi.nlm.nih.gov] Cell surface biotinylation analysis using Flp-In T-REx 293 cells showed that ectopic expression of Ub(Δ)(GG), which is ubiquitin (Ub) lacking the two C-terminal glycines essential[ncbi.nlm.nih.gov] Glycine- and taurine-conjugated bile acids were rapidly formed in hepatocytes and effectively transported into the extracellular medium.[ncbi.nlm.nih.gov] Pathophysiology Bile acid is generated from an amino acid, Glycine, and Taurine. Definition of bile salts: Bile acids conjugated with taurine or glycine in the liver.[labpedia.net] Imagawa K 1, 2, 3 , Takayama K 2, 3, 4 , Isoyama S 1 , Tanikawa K 5 , Shinkai M 6 , Harada K 7 , Tachibana M 2 , Sakurai F 2, 8 , Noguchi E 9 , Hirata K 7 , Kage M 5 , Kawabata[ncbi.nlm.nih.gov] The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol.[reactome.org]

    Missing: N methyl N ((3alpha 12 trihydroxy 24 oxocholan 24 yl)
  • Cerebrotendinous Xanthomatosis

    Cholesterol 7alpha-hydroxylase (CYP7A1) and Na /taurocholate-cotransporting polypeptide (NTCP) were upregulated 84- and 8-fold, respectively.[ncbi.nlm.nih.gov] Recent studies have shown that plasma cholestane-3β,5α,6β-triol (CT) and 7-ketocholesterol (7-KC) could be potential biomarkers for the diagnosis of NPC patients.[ncbi.nlm.nih.gov] Phosphoserin-Phosphatase PSP 7p15.2-p15.1 Glycin-Enzephalopathie Glycin-Dehydrogenase GLDC 9p22 Glycin-Enzephalopathie (GCE) Aminomethyltransferase AMT 3p21.2-p21.1 Primäre[de.wikibooks.org] ESI-MS/MS quantification of 7alpha-hydroxy-4-cholesten-3-one facilitates rapid, convenient diagnostic testing for cerebrotendinous xanthomatosis.[emedicine.medscape.com] Serum cholestanol analysis was 7 µmol/l (N). After 2 years, she was bedridden and died of aspiration pneumonia.[ncbi.nlm.nih.gov] Sasamura A 1 , Akazawa S 1 , Haraguchi A 1 , Horie I 1 , Ando T 1 , Abiru N 1 , Takei H 2 , Nittono H 2 , Une M 3 , Kurosawa T 4 , Murai T 4 , Naruse H 5, 6 , Nakayama T 5, 7[ncbi.nlm.nih.gov] […] one 12alpha-hydroxylase, CYP27A1, and NTCP.[ncbi.nlm.nih.gov]

    Missing: N methyl N ((3alpha 5beta 12 trihydroxy 24 oxocholan 24 yl)
  • Congenital Bile Acid Synthesis Defect Type 2

    LSIMS urine analysis reveals elevated amounts of delta(4)-3-oxo bile acids including 3-oxo-7alpha-hydroxy-4-cholenoic and 3-oxo-7alpha, 12alpha-dihydroxy-4-cholenoic acids[orpha.net] This enzyme is encoded by the AKR1D1 gene, located on the long arm of chromosome 7.[symptoma.com] Mol Nutr Food Res. 2012;56(7):1122-1130. (PubMed) 92. Blount BC, Mack MM, Wehr CM, et al.[lpi.oregonstate.edu] […] nuovo elenco MR esenti Dati tratti dal Supplemento ordinario n. 15 alla GAZZETTA UFFICIALE Serie generale - n. 65 18-3-2017 ALLEGATO 7 (da pag. 247 a pag. 265) CODICE MALATTIA[retemalattierare.it] LSIMS urine analysis reveals elevated amounts of delta(4)-3-oxo bile acids including 3-oxo-7alpha-hydroxy-4-cholenoic and 3-oxo-7alpha, 12alpha-dihydroxy-4-cholenoic acids[orpha.net] CBAS2 is associated with an increase of levels of the glycine and taurine conjugates of 7α-hydroxy-3-oxo-4-cholenoic acid and 7α,12α-dihydroxy-3-oxo-4-cholenoic acid, while[symptoma.com] Proc Natl Acad Sci U S A. 1997;94(7):3290-3295. (PubMed) 93. Narayanan S, McConnell J, Little J, et al.[lpi.oregonstate.edu]

    Missing: N methyl N ((3alpha 5beta 12 trihydroxy 24 oxocholan 24 yl)
  • Medroxyprogesterone

    0.9540 C15126 2,17beta-Dihydroxy-17-methylandrosta-1,4-dien-3-one 0.9540 C15287 11beta,17beta-Dihydroxy-17alpha-methylandrosta-1,4-dien-3-one 0.9540 C15402 17beta-Hydroxy-7alpha[genome.jp] AIDS Behav. 2017 Jul;21(7):2173-2179. doi: 10.1007/s10461-016-1563-y.[ncbi.nlm.nih.gov] At 7-day follow-up, 18 of 19 contacted participants (94.7%) were satisfied with timing of DMPA administration.[ncbi.nlm.nih.gov] We ascertained abortion outcome, pregnancies, and contraception use over 7 months.[ncbi.nlm.nih.gov] Dihydroprogesterone 5a-Pregnane-3,20-dione 5b-Pregnane-3,20-dione 5-a-Dihydroprogesterone 5alpha Pregnane 3,20 dione 5alpha-Pregnane-3,20-dione 3,20-Allopregnanedione, (5beta[selfdecode.com] […] one 0.8705 C15194 Androsta-4,9(11)-diene-3,17-dione 0.8702 C14982 6beta,17-Dimethyl-5alpha-androstane-3beta,17beta-diol 0.8681 C15165 12alpha-Fluoro-11beta,17beta-dihydroxyandrosta[genome.jp] Heffron R 1, 2 , Parikh UM 3 , Penrose KJ 3 , Mugo N 4, 5 , Donnell D 4, 6 , Celum C 4, 7, 8 , Mellors JW 3, 9, 10 , Baeten JM 4, 7, 8 ; Partners PrEP Study Team .[ncbi.nlm.nih.gov]

    Missing: Glycine N methyl N ((3alpha 12 trihydroxy 24 oxocholan 24 yl)
  • Smith Lemli Opitz Syndrome

    Rat microsomal cholesterol 7alpha-hydroxylase did not transform 7-dehydrocholesterol or 8-dehydrocholesterol into 7alpha-hydroxylated sterols.[ncbi.nlm.nih.gov] […] dehydrocholesterol Delta(7)-reductase (DHCR7).[ncbi.nlm.nih.gov] The p.G366V is a novel mutation of the DHCR7 gene with guanine by thymine nucleotide exchange resulting in glycin by valin amino acid exchange in the dehydrocholesterol reductase[ncbi.nlm.nih.gov] Biochemically, the disorder is caused by deficient activity of 7-dehydrocholesterol reductase, which catalyzes the reduction of the Delta7 double bond of 7-dehydrocholesterol[ncbi.nlm.nih.gov] […] is, the reduction of the Delta7 double bond of 7-dehydrocholesterol to produce cholesterol.[ncbi.nlm.nih.gov] In the SLOS patients, cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase were not defective.[ncbi.nlm.nih.gov] All tissues analysed showed elevated 7-DHC with markedly increased 7-DHC/cholesterol ratios. Copyright 2000 John Wiley & Sons, Ltd.[ncbi.nlm.nih.gov]

    Missing: N methyl N ((3alpha 5beta 12alpha) 3 12 trihydroxy 24 oxocholan 24 yl)
  • Lindane

    We present a case of a 7 year old boy who had suffered from scabies 1 week ago, for which he was prescribed lindane along with other medications by a general practitioner.[ncbi.nlm.nih.gov] We also investigated the mechanisms by which lindane and fipronil inhibit α1 glycine receptors.[ncbi.nlm.nih.gov] ,6beta)-( -)-isomer, beta-hexachlorocyclohexane, (1alpha,2alpha,3alpha,4alpha,5alpha,6alpha)-isomer, beta-hexachlorocyclohexane, (1alpha,2alpha,3alpha,4alpha,5beta,6beta)-[prepchem.com] Chromosomal damage in MCF-7 breast cells and PC-3 prostate cells was assessed using the cytokinesis block micronucleus assay.[ncbi.nlm.nih.gov] An increase in SOD and catalase activities was observed in the 7-mg/kg/day dose of lindane. Interstitial edema in the myocardium was observed in both doses.[ncbi.nlm.nih.gov] Specifically, in Hep G2 cells with this pesticide, the glycine peak (3.56 ppm) was lowered, thus confirming that the glycine synthesis pathway involving methionine, choline[ncbi.nlm.nih.gov] CONCLUSIONS AND IMPLICATIONS: This study implicates glycine receptors as novel vertebrate toxicity targets for fipronil and lindane.[ncbi.nlm.nih.gov]

    Missing: N methyl N ((3alpha 7alpha 12alpha) 3 12 trihydroxy 24 oxocholan 24 yl)
  • Paclitaxel

    Methods: The PTX/SPIO-SSL-H 7 K(R 2 ) 2 was prepared by a thin film hydration method. The characteristics of PTX/SPIO-SSL-H 7 K(R 2 ) 2 were evaluated.[ncbi.nlm.nih.gov] Purpose: In this study, a novel arginine, glycine, aspartic acid peptide (RGD)-modified paclitaxel and curcumin co-loaded liposomes were developed to evaluate their antitumor[ncbi.nlm.nih.gov] 2a,3,4,4a,5,6,9,10,11,12,12a,12b- dodecahydro- 4,11- dihydroxy- 4a,8,13,13- tetramethyl- 5- oxo- 7,11- methano- 1H- cyclodeca(3,4)benz(1,2- b)oxet- 9- yl ester ChemIDplus 5beta[ebi.ac.uk] DPT remarkably suppressed tumor growth in xenograft mice bearing either paclitaxel (PTX)-sensitive MCF-7/S or acquired resistance MCF-7/Adr (MCF-7/A) cells.[ncbi.nlm.nih.gov] Adv-siSurv infection reduced survivin, procaspase-9, and procaspase-3 levels in paclitaxel-treated MCF-7 cells.[ncbi.nlm.nih.gov] […] iron oxide nanoparticles (SPIO NPs), PTX/SPIO-SSL-H 7 K(R 2 ) 2 , was prepared by using H 7 K(R 2 ) 2 as the targeting ligand, SPIO NPs as the magnetic resonance imaging[ncbi.nlm.nih.gov] In vitro, DPT exhibited a much lower resistance index (0.552) than those of PTX (754.5) or etoposide (38.94) in both MCF-7/S and MCF-7/A cells.[ncbi.nlm.nih.gov]

    Missing: N methyl N ((3alpha 7alpha 12alpha) 3 12 trihydroxy 24 oxocholan 24 yl)
  • Androgens

    Androgen levels including their 7alpha-, 7beta-, and 16alpha-hydroxy-metabolites were further restrained by GC-therapy.[ncbi.nlm.nih.gov] Ose J 1, 2 , Poole EM 3 , Schock H 1 , Lehtinen M 4 , Arslan AA 5, 6 , Zeleniuch-Jacquotte A 6 , Visvanathan K 7 , Helzlsouer K 7 , Buring JE 8, 9 , Lee IM 8, 9 , Tjønneland[ncbi.nlm.nih.gov] In the XXY-man the major metabolites were 5alpha- and 5beta-androstanediols, whereas in the normal men 5alpha-dihydrotestosterone and 4-androstenedione were mainly formed[ncbi.nlm.nih.gov] The plasma DHEA-S concentration was normal for chronological age in 9 of 12 patients and for bone age in 7 of 10 patients.[ncbi.nlm.nih.gov] Median time for return to International Prostate Symptom Score 5 of baseline score was 7 months (interquartile ratio, 6-13).[ncbi.nlm.nih.gov] 6 Department of Population Health and Environmental Medicine, New York University School of Medicine; Perlmutter Cancer Center, New York University, New York, New York. 7[ncbi.nlm.nih.gov] In contrast, the concentration of plasma delta 4 A was raised for chronological age in 6 of 13 patients and for bone age in 7 of 10 patients.[ncbi.nlm.nih.gov]

    Missing: Glycine N methyl N ((3alpha 12alpha) 3 12 trihydroxy 24 oxocholan 24 yl)
  • Croton

    Abstract Two new 8,9-secokaurane diterpenes, ent-8,9-seco-7alpha,11beta-diacetoxykaura-8(14),16-dien-9,15-dione (1) and ent-8,9-seco-8,14-epoxy-7alpha-hydroxy-11beta-acetoxy[ncbi.nlm.nih.gov] Compound 2 showed a potent cytotoxic activity against MCF-7, tamoxifen-resistant MCF-7 (MCF-7/TAMR), adriamycin-resistant MCF-7 (MCF-7/ADR), and MDA-MB-231 breast cancer cell[ncbi.nlm.nih.gov] Crofelemer did not affect the potency of glycine hydrazide or thiazolidinone CFTR inhibitors.[ncbi.nlm.nih.gov] A significant reduction in Huh-7 cell migration induced by crourorb A1 was also observed in the presence of mitomycin C.[ncbi.nlm.nih.gov] (1), four new abietane-type diterpenoids, crotontomentosins B-E (2-5), one new ent-halimane-type diterpenoid, crotontomentosin F (6), along with five known diterpenoids (7-[ncbi.nlm.nih.gov] -16-kauren-9,15-dione (2), together with two known compounds, ent-8,9-seco-7alpha-hydroxy-11beta-acetoxykaura-8(14),16-dien-9,15-dione (3) and ent-7beta-hydroxy-15-oxokaur[ncbi.nlm.nih.gov] […] cells, through the activation of caspase-3/7 and increased expression of the pro-apoptotic proteins Bak, Bid, Bax, Puma, Bim, and Bad.[ncbi.nlm.nih.gov]

    Missing: N methyl N ((3alpha 5beta 12alpha) 3 12 trihydroxy 24 oxocholan 24 yl)