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18 Possible Causes for Glycophosphatidylinositol

  • Paroxysmal Nocturnal Hemoglobinuria Type 1

    […] stem cell defect with an annual incidence of 1.3 in 1 million individuals. 1 It is caused by a somatic mutation of the X-linked PIG-A gene, which leads to deficiency of glycophosphatidylinositol-anchored[questdiagnostics.com] PNH patients have decreased expression of a protein called glycophosphatidylinositol (GPI) anchor proteins on red blood cells.[clinicaladvisor.com] In normal individuals, this gene encodes an enzyme involved in the first stage of glycophosphatidylinositol (GPI) biosynthesis.[asmscience.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder associated with an acquired deficiency in glycophosphatidylinositol-anchor biosynthesis[ncbi.nlm.nih.gov] FLAER binds selectively to the glycophosphatidylinositol anchor and is more accurate in demonstrating a deficit than simply for CD59 or CD55.[en.wikipedia.org] PNH is caused by an acquired (somatic) mutation in the X-linked phosphatidyl-inositol glycan (PIG-A) gene which results in reduced/absent synthesis of glycophosphatidylinositol[propath.com]

  • Hemoglobinuria

    PNH is the only hemolytic anemia caused by an acquired (rather than inherited) intrinsic defect in the cell membrane (deficiency of glycophosphatidylinositol leading to absence[enerca.org] 1,000,000) involving a clonal acquired X-linked somatic mutation of the phosphatidylinositol glycan class A (PIGA) gene, results in a partial, or total, deficiency of the glycophosphatidylinositol[academic.oup.com] PIGA phosphatidylinositol glycan class A FCM flow cytometry FLAER fluorescent inactivated aerolysin HT hemolysis test SLT sucrose lysis test mAbs monoclonal antibodies GPI glycophosphatidylinositol[academic.oup.com]

  • Hereditary Cryohydrocytosis with Reduced Stomatin

    Can lead to peripheral ____cytopenia lack anchored membrane proteins such as GPI (glycophosphatidylinositol) lead to pancytopenia PNH: Clinical findings __________ in first[quizlet.com]

  • Hyperphosphatasia with Mental Retardation Syndrome 4

    Glycosylphosphatidylinositol Glycosylphosphatidylinositol (pronunciation ), or glycophosphatidylinositol, or GPI in short, is a glycolipid that can be attached to the C-terminus[howlingpixel.com]

  • Immunodeficiency due to a C5 to C9 Complement Component Deficiency

    […] rare, acquired, potentially life-threatening disease charcterized by complement induced intravascular hemolytic anemia, red uring, and thrombosis a genetic deficiency of glycophosphatidylinositol[brainscape.com]

  • Pleural Mesothelioma

    Abstract Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly expressed in several types of malignant tumors sometimes in association[ncbi.nlm.nih.gov]

  • Hereditary Cryohydrocytosis with Normal Stomatin

    Can lead to peripheral ____cytopenia lack anchored membrane proteins such as GPI (glycophosphatidylinositol) lead to pancytopenia PNH: Clinical findings __________ in first[quizlet.com]

  • Hyperphosphatasia with Mental Retardation Syndrome 3

    Glycosylphosphatidylinositol ( pronunciation ( help · info ) ), or glycophosphatidylinositol , or GPI in short, is a glycolipid that can be attached to the C-terminus of a[en.wikipedia.org]

  • Candida Albicans

    Als3p, a member of the C. albicans agglutinin-like sequence (ALS) family, is a hyphal-specific glycophosphatidylinositol cell wall protein that plays a key role in the interaction[ncbi.nlm.nih.gov] Fu et al . [28] established a collection of 26 heterozygous OE strains for genes encoding glycophosphatidylinositol-anchored (GPI) proteins.[doi.org]

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