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127 Possible Causes for H2AX

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  • Idarubicin

    Additionally, DSB formation was examined using H2AX histone phosphorylation assays.[ncbi.nlm.nih.gov] […] of DNA strand breaks in sensitive MCF7 cells detected by TUNEL assessments (p 0.0011 for IDA alone and p 0.0109 for IDA reductively activated, Kruskal-Wallis test) and γ-H2AX-positive[ncbi.nlm.nih.gov]

  • Meningioma

    LB-100 increased DNA double-strand breakage (measured by γ-H2AX), mitotic catastrophe cell death, and G2/M cell cycle arrest in irradiated meningioma cells.[ncbi.nlm.nih.gov]

  • Mitoxantrone

    Moreover, their combination induces: i) a cytotoxic effect by apoptotic death, ii) a mild G2/M elongation and iii) H2AX and mild PI3K activation.[ncbi.nlm.nih.gov]

  • Norethindrone

    No p53 activation or H2AX phosphorylation was detected using a panel of structurally/functionally related drugs.[ncbi.nlm.nih.gov] DSBs were not detected with the neutral comet assay, a less sensitive method for DSB assessment than H2AX phosphorylation.[ncbi.nlm.nih.gov] Norethindrone at concentrations of 2-100 microg/ml activated p53 and phosphorylated H2AX specifically and in a dose-dependent manner.[ncbi.nlm.nih.gov]

  • Radiation Therapy

    An increased number of γ-H2AX-positive nuclei was observed, suggesting a possible impairment of the DNA repair machinery.[ncbi.nlm.nih.gov] METHODS: The radio-sensitizing effect of enzalutamide was assessed in the androgen-dependent LNCaP cells and the androgen-independent PC3 cells by clonogenic assay and γ-H2AX[ncbi.nlm.nih.gov]

  • Troglitazone

    […] spectrometry, we showed a dose-dependent increase in cell killing in TRG and HDACi treated cells, that was associated with increased H3 lysine 9 (H3K9) and H3K23 acetylation, H2AX[ncbi.nlm.nih.gov]

  • Alkylating Agent

    However, melphalan induces γ-H2AX in melphalan-sensitive cells at 6 h and 24 h; no γ-H2AX induction was observed in melphalan-resistant cells even after 24 h exposure.[ncbi.nlm.nih.gov] PKs of DMS612 and metabolites were assessed by mass spectroscopy and PD by γ-H2AX immunofluorescence.[ncbi.nlm.nih.gov] DNA damage and repair state were determined by γ-H2AX foci, and mitotic catastrophe was measure using nuclear fragmentation.[ncbi.nlm.nih.gov]

  • Seckel Syndrome

    […] showed that impaired CEP152 function leads to accumulation of genomic defects resulting from replicative stress through enhanced activation of ATM signaling and increased H2AX[ncbi.nlm.nih.gov] Phosphorylation of H2AX on Ser139 (p-H2AX) after HU was detected using IF with phosphospecific antibodies. Nuclei were counterstained with DAPI.[academic.oup.com] […] these γ H2AX positive cells that also displayed RPA foci.[journals.plos.org]

  • Cantharidin

    Cantharidin treatment in the HCSCs for 48 h increased expression of histone H2AX, Myt1, cyclin A2, cyclin B1, p53 and cdc2 (Tyr15) phosphorylation significantly compared to[ncbi.nlm.nih.gov]

  • Mental Retardation

    Meiosis Mice Mice, Knockout Mutation Neurons/metabolism Prophase Receptors, AMPA/metabolism Spermatogenesis* Substances Chromatin FMR1 protein, human Fmr1 protein, mouse H2AX[ncbi.nlm.nih.gov]

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