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75 Possible Causes for HIF1, protein

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  • Stress

    Abstract It is well established today that heterologous overexpression of proteins is connected with different stress reactions.[ncbi.nlm.nih.gov] Additionally, LBP decreased MMP disruption and cell apoptosis induced by H2O2, by increasing the mRNA and protein expression of survivin, HIF1‑α and Bcl‑2 and decreasing Bax[ncbi.nlm.nih.gov] Yes-associated protein (YAP) is a powerful regulator and is overexpressed in many cancers, including HCC.[ncbi.nlm.nih.gov]

  • Aldehyde

    The six human SUMO specific SENP enzymes (1-3, 5-7), have been shown to participate in non-redundant cellular functions such as HIF1-α stabilization during hypoxia, mitosis[enzolifesciences.com] Known single nucleotide polymorphisms had no effect on the protein levels of these proteins.[ncbi.nlm.nih.gov] , human Aldehyde Dehydrogenase, Mitochondrial AMP-Activated Protein Kinases[ncbi.nlm.nih.gov]

  • Hypoxia

    Sitkovsky M, Lukashev D (2005) Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.[link.springer.com] BLAST Align Show all Add to basket E9PJ21 E9PJ21_HUMAN Hypoxia up-regulated protein 1 HYOU1 656 Annotation score: J3QL06 J3QL06_HUMAN Hypoxia up-regulated protein 1 HYOU1[uniprot.org] […] genetics Receptors, G-Protein-Coupled/metabolism Sequence Analysis, RNA Transcriptional Activation Substances HIF1A protein, human Hypoxia-Inducible Factor 1, alpha Subunit[ncbi.nlm.nih.gov]

  • Glioblastoma Multiforme

    Serum VEGF and tumor tissue HIF1-alpha levels were measured by enzyme-linked immunosorbent assay.[ncbi.nlm.nih.gov] Thus, protein kinases are a growing drug target class for cancers including glioblastoma.[ncbi.nlm.nih.gov] In this study, we demonstrate tumor expression of epithelial membrane protein-2 (EMP2) promotes angiogenesis both in vitro and in vivo using cell lines from human GBM.[ncbi.nlm.nih.gov]

  • Deferoxamine

    Interestingly, we found that DFO up-regulated the expression of HIF-1α protein, TH, vascular endothelial growth factor (VEGF), and growth associated protein 43 (GAP43) and[ncbi.nlm.nih.gov] To induce HIF1 alpha protein levels, HeLa cells were treated with 500 µM DFO (ab120727) for 24 hours. - Deferoxamine mesylate (ab120727) Dose-dependent induction of HIF1 alpha[abcam.com] In contrast, the mRNA levels of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, sterol regulatory element-binding proteins, and the mRNA/protein levels of proprotein convertase[ncbi.nlm.nih.gov]

  • Facioscapulohumeral Muscular Dystrophy

    Our analysis identified β-catenin as the main coordinator of FSHD-associated protein interaction signalling, with pathways including canonical Wnt, HIF1-α and TNF-α clearly[ncbi.nlm.nih.gov] After each session, patients drank either a protein-carbohydrate or placebo beverage.[ncbi.nlm.nih.gov] This study will investigate the contribution of sarcomeric protein dysfunction to the pathogenesis of muscle weakness in FSHD.[ncbi.nlm.nih.gov]

  • Cordyceps Sinensis

    Overall, Cordyceps sinensis treatment inhibited hypoxia induced oxidative stress by maintaining higher cellular Nrf2, HIF1 and lowering NF κ B levels.[ncbi.nlm.nih.gov] Western blot analysis demonstrated that, after treatment with CS for 3 h, protein levels of steroidogenic acute regulatory protein (StAR) and aromatase were upregulated while[ncbi.nlm.nih.gov] […] several major events in the mitochondrial signal pathway occurred, including the loss of MTP (DeltaPsi(m)), cytochrome c release into the cytoplasm, the decrease in Bcl-2 protein[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    […] genetics Neoplasm Proteins/metabolism Sulfonamides/therapeutic use* Substances Bridged Bicyclo Compounds, Heterocyclic CDKN2A protein, human CDKN2B protein, human Cyclin-Dependent[ncbi.nlm.nih.gov] It regulates important transcription factors, such as E2F2, hypoxia-inducible factor 1 (HIF1), and FOXO3.[ncbi.nlm.nih.gov] […] metabolism* Transfection Tumor Microenvironment/genetics Substances KLF6 protein, human Kruppel-Like Factor 6 Protein Isoforms RNA, Messenger RNA, Neoplasm RNA, Small Interfering[ncbi.nlm.nih.gov]

  • Somatostatinoma

    , decreasing the hydroxylation of HIF2α, and reducing HIF2α affinity for the von Hippel-Lindau protein and its degradation.[ncbi.nlm.nih.gov] […] oval nuclei Stippled chromatin (“salt and pepper”) Typically 5cm Immunohistochemistry Synaptophysin, chromogranin A, pan cytokeratin, Ki-67, neuron specific enolase (NSE), protein[arupconsult.com] Immunohistochemical staining for HIF1/2α was performed on formalin-fixed, paraffin-embedded tumor tissue.[ncbi.nlm.nih.gov]

  • Hemangioblastoma

    Immunofluorescent staining revealed the cellular localization of these proteins.[ncbi.nlm.nih.gov] HIF1-α and Hif-2α expression after propranolol treatment was analyzed by western blotting.[ncbi.nlm.nih.gov] Immunohistochemical study revealed that the tumor stromal cells were positive for CD56, S-100 protein, NSE, Syn, CgA, and inhibin-α. Focal EMA positivity was present.[ncbi.nlm.nih.gov]

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