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22 Possible Causes for HIF1 ALPHA

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  • Secondary Polycythemia

    The activity of HIF1-alpha is increased by a lowered oxygen tension.[emedicine.medscape.com] Hypoxia-inducible factor 1-alpha (HIF1-alpha) binds to the hypoxia-responsive element, which is downstream of the gene for EPO.[emedicine.medscape.com] In this condition, and in hypoxia, the undegraded HIF1-alpha forms a heterodimer with HIF-beta and leads to increased transcriptions of the gene for EPO.[emedicine.medscape.com]

  • Deferoxamine

    To induce HIF1 alpha protein levels, HeLa cells were treated with 500 µM DFO (ab120727) for 24 hours. - Deferoxamine mesylate (ab120727) Dose-dependent induction of HIF1 alpha[abcam.com] The HIF1 alpha detector antibody was used to blot the same lysates as analyzed by SimpleStep ELISA (40 µg loaded/lane).[abcam.com] In the HeLa cell line, DFO treatment is required to detect HIF1 alpha protein by both SimpleStep ELISA and western blot.[abcam.com]

  • Testicular Atrophy

    The expression of protamine 2 as a marker for elongated spermatids, inflammation markers (CD4, F4/80) and hypoxia inducible factor 1 alpha (HIF1 alpha) were investigated using[ncbi.nlm.nih.gov]

  • Glioblastoma Multiforme

    Serum VEGF and tumor tissue HIF1-alpha levels were measured by enzyme-linked immunosorbent assay.[ncbi.nlm.nih.gov] Tumor HIF1-alpha and serum VEGF levels were found to be significantly increased in IDH1 -mutated tumor tissues ( p p 0.0454, respectively).[ncbi.nlm.nih.gov]

  • Hypoxia

    Sitkovsky M, Lukashev D (2005) Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors.[link.springer.com]

  • Carcinoma

    Increased levels of HIF1 alpha have been associated independently with poor prognosis in lymph node negative breast carcinoma (Bos et al., 2003).[atlasgeneticsoncology.org] ., 2004), HIF1 alpha has been shown to be overexpressed in sporadic breast cancer, and even more in BRCA1-related hereditary breast cancer (van der Groep et al., 2008).[atlasgeneticsoncology.org]

  • Medulloepithelioma

    Upregulation of HIF1-alpha (HIF-1α) is associated with adverse outcomes in patients with neuroblastoma [ 54 ] and other tumors as previously described in this report.[journals.plos.org]

  • Intraocular Medulloepithelioma

    Upregulation of HIF1-alpha (HIF-1α) is associated with adverse outcomes in patients with neuroblastoma [ 54 ] and other tumors as previously described in this report.[journals.plos.org]

  • Nasopharyngeal Disease

    Hypoxia inducible factor 1-alpha (HIF1-alpha) is a hypoxia inducible transcription factor which upregulates the expression of various important mediators of angiogenesis such[journalofnasopharyngealcarcinoma.org] HIF1-alpha is overexpressed in 50% of NPC and is associated with shorter survival following radiotherapy in patients with advanced NPC [50].[journalofnasopharyngealcarcinoma.org]

  • Succinum

    -alpha or GPR91 signaling in innate immune cells.[en.wikipedia.org] […] tumor invasion. [6] [38] Role in human health [ edit ] Inflammation [ edit ] Metabolic signaling involving succinate can be involved in inflammation via stabilization of HIF1[en.wikipedia.org]

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