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155 Possible Causes for HIF1A

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  • Neonatal Hypoxic and Ischemic Brain Injury

    Positive outcomes of this project will shed new insights into the roles of HIF1a in neonates and suggest a novel strategy for brain protection in newborns.[grantome.com] Hypoxia Inducible Factor-1a (HIF1a), a key regulator of cellular adaptation to hypoxia and oxidative stress, ameliorates adult cerebral ischemia and myocardial infarction[grantome.com] In this R21 proposal, we will test the hypothesis that intranasal delivery of GSK360A, a potent PHD inhibitor, produces CNS-specific stabilization of HIF1a to oppose neonatal[grantome.com]

  • Monosomy 1p36 Syndrome

    […] cortical development Sugiura et al. 2014 A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles Ferreira et al. 2013 STUB1/CHIP is required for HIF1A[google.sr]

  • Oculopalatoskeletal Syndrome

    Defects, Congenital HIF1A TBX1 ZEB2 Prostatic Neoplasms ARL6IP1 ERBB2 HIF1A Disease Progression CDH2 ERBB2 ZEB2 Thyroid Carcinoma HIF1A RET Nervous System Malformations PAX3[selfdecode.com] , Experimental ALDH1L1 LBH NRG1 ZEB2 Glioma ACVR1 ERBB2 GDNF Skin Neoplasms ERBB4 HIF1A SMO Autism DISC1 NRP2 PAX6 Mammary Neoplasms, Animal ERBB2 KITLG SOX9 Carcinoma HIF1A[selfdecode.com] EDNRB HIF1A HTR2B Heart Failure HIF1A HTR2B NRG1 Mammary Neoplasms, Experimental ERBB2 KITLG SOX9 Status Epilepticus CDH2 GDNF RET Neoplasm Metastasis CDH2 CFL1 ERBB2 Heart[selfdecode.com]

  • Hypoxia

    Reactive Oxygen Species/analysis Receptors, G-Protein-Coupled/genetics Receptors, G-Protein-Coupled/metabolism Sequence Analysis, RNA Transcriptional Activation Substances HIF1A[ncbi.nlm.nih.gov] In response to low oxygen levels, the tumor cells trigger the synthesis of hypoxia-inducible factor 1a (HIF1a), a protein that directly represses the transcription of miR-[en.uni-muenchen.de] Proteoglycans/metabolism Single-Cell Analysis Stromal Cells/pathology Time Factors Substances Antigens, CD CDH2 protein, human Cadherins Cell Adhesion Molecules Drug Combinations HIF1A[ncbi.nlm.nih.gov]

  • Colorectal Carcinoma

    Serum level of HIF1A-AS1 was detected via real-time PCR (RT-PCR).[ncbi.nlm.nih.gov] HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol. 2010;176(5):2292–301.[bmcbioinformatics.biomedcentral.com] Then HIF1A-AS1 in CRC was divided into high- and low-expression groups, and the associations of the HIF1A-AS1 serum level with clinicopathological features and prognosis were[ncbi.nlm.nih.gov]

  • Hemangioma

    Overexpression of HIF1A attenuated the anti-proliferation effect of miR-199a mimic in HAs cells.[ncbi.nlm.nih.gov] Furthermore, HIF1A was identified as a target of miR-199a and had negative correlation with miR-199a expression in proliferating-phase HAs.[ncbi.nlm.nih.gov] Taken together, our findings demonstrate that miR-199a may inhibit proliferation and induce apoptosis in HAs cells via targeting HIF1A and provide a potential therapeutic[ncbi.nlm.nih.gov]

  • Anaplastic Astrocytoma

    Our analysis suggests that many of the most statistically significant genes work together in a HIF1A/VEGF-regulated network to increase angiogenesis and invasion in GBM when[ncbi.nlm.nih.gov] Figure 3 Relationship of HIF1A and VEGFA to top meta-analysis genes . Relationships from the literature among HIF1A , VEGFA , and some of the top 30 meta-analysis genes.[molecular-cancer.biomedcentral.com] When considered together, these genes suggest differential activation of the HIF1A/VEGF network in GBM when compared to AA.[molecular-cancer.biomedcentral.com]

  • Diabetic Embryopathy

    We have performed gene expression profiling of Hif1a partially deficient adult mutant mice.[cordis.europa.eu] The expression patterns of vascular endothelial growth factor A ( Vegfa ), hypoxia inducible factor 1 alpha ( Hif1a ), platelet derived growth factor receptor alpha ( Pdgfr[atlasofscience.org] In contrast to non-mutant mice, sustained hypoxia activates the transcriptional responses of the majority of analysed genes in the Hif1a mutant left ventricle.[cordis.europa.eu]

  • Von Hippel-Lindau Disease

    Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases.[abcam.com] Regulation of transcription factors: HIF1a and HIF2a Cells lacking pVHL fail to degrade HIFs in the presence of oxygen, thus permitting accumulation of high levels of stable[emedicine.com] Two key targets recruited to the protein complex under normal oxygen conditions are the transcription factors HIF1a (hypoxia-inducible factor-1a) and HIF2a (hypoxia-inducible[emedicine.com]

  • Polycythemia

    Moreover, protein levels of VHL, HIF1A, HIF2A, EPO, and VEGF estimated by immunohistochemical staining substantiated hyperactivation of the oxygen-sensing pathway.[ncbi.nlm.nih.gov] […] builder or humoral replacement (e.g. testolone, a selective androgen receptor modulator), hemoglobin mutants with high oxygen affinity or an inherited defect that stabilizes HIF1a[pathologyoutlines.com] Consequently, we looked for mutations in the HIF1A gene and in 2 genes (ie, elongin B and elongin C) that encode other components of the E3 complex that ubiquitinates HIF-[dx.doi.org]

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