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1,852 Possible Causes for HISTONES

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  • Drug-induced Fever

    Thus they are called anti-histone antibodies. Anti-histone antibodies may be seen in both systemic lupus erythematosus and drug-induced lupus.[] The antihistone antibodies in DIL primarily form against a complex of the histone dimer H2A-H2B, which is in contrast to idiopathic SLE in which complexes are formed against[] Anti-histone antibodies are often ordered to diagnosis DIL. However, they are positive in systemic lupus erythematosus at the same rates (75%).[]

  • Viral Lower Respiratory Infection

    Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.[]

  • Pseudogout

    Released extracellular DNA binds myeloperoxidase and citrullinated histone H4.[]

  • Depression

    There are changes in gut microbiota composition and gut microbial profile (butyrate, GABA, β-hydroxybutyrate) effecting epigenetic regulation (histone acetylation, DNA methylation[]

  • Smoking

    The first mechanism is associated with the histone acetylation/deacetylation balance damage as a result of increased activity of NFĸB and lipid peroxidation products, which[]

  • Disseminated Intravascular Coagulation

    Clinically, high circulating levels of histones and histone-DNA complexes are associated with multiorgan failure, DIC, and adverse patient outcomes.[] KEYWORDS: Platelets; anticoagulation; coagulation; disseminated intravascular coagulation; histones[] Recent observations have pointed to an important role for extracellular DNA and DNA-binding proteins, such as histones, in the pathogenesis of DIC.[]

  • Aortic Valve Stenosis

    This review will examine the known relationships between four major epigenetic mechanisms: DNA methylation, posttranslational histone modification, ATP-dependent chromatin[]

  • Arsenical

    We show changes in histone H3 acetylation occur during arsenical-induced malignant transformation that are linked to the expression state of the associated gene.[] This WNT5A transcriptional activation is correlated with the enrichment of permissive histone modifications and the reduction of repressive modifications in the WNT5A promoter[] We evaluated the potential epigenetic component of arsenical action by assessing the histone acetylation state of 13 000 human gene promoters in a cell line model of arsenical-mediated[]

  • Cutaneous Vasculitis

    Some patients also have antibodies against histones and antiphospholipid.[]

  • Propylthiouracil

    ANA, anti-DNA, and anti-histone were predominantly found in DIL, while p-ANCA was found in a similar proportion of patients in both groups. c-ANCA was detected only in patients[]

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