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10 Possible Causes for HOX11L2

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  • T-cell Acute Lymphoblastic Leukemia

    […] loci (1/3 of T ALL): 14q11.2 (alpha, delta) 7q35 (beta) 7p(14-15) (gamma) Genes: MYC (8q24.1) TAL1 (1p32) RBTN1 (LMO1) (11p15) RBTN2 (LMO2) (11p13) HOX11 (TLX1) (10q24) HOX11L2[pathologyoutlines.com] […] p15;q11.2) - LMO1/TRAD t(11;19)(q23;p13.1) - MLL/ELL t(11;19)(q23;p13.3) - MLL/MLLT1 or MLL/ENL t(4;11)(q21;q23) - AFF1/MLL or AFF4/MLL t(5;14)(q35;q32) - TLX3/BCL11B or HOX11L2[mayomedicallaboratories.com]

  • Bilineal Acute Leukemia

    Pediatr Blood Cancer 2011;56:467469. 2010 Wiley-Liss, Inc.Key words: acute bilineal leukemia; ambiguous; BCL11B; biphenotypic; HOX11L2; MPAL; t(5 ;14), 9q; T-ALL; TLX3; T[docslide.com.br] HOX11L2/TLX3 istranscriptionally activated through T-cell regulatory elementsdownstream of BCL11B as a result of the t(5;14)(q35;q32).Blood 2006;108:41984201 [Epub 2006 August[docslide.com.br] […] cytoge-netic abnormalities associatedwithAMLwerewithin normal limits.Additional FISH studies performed on the bonemarrow core biopsyusing a break apart strategy mapped to the TLX3(HOX11L2[docslide.com.br]

  • T-Cell Lymphoblastic Lymphoma

    About a fourth of T-LBL patients shows chromosomal anomalies involving HOX11L2/TLX3, which may predict a worse outcome.[symptoma.com] ;q11): SCL (TAL1) and T cell receptor delta / alpha (15 - 30%) t(10;14)(q24;q11): HOX11 (TLX1) and T cell receptor delta / alpha (7% of childhood and 30% of adult cases) HOX11L2[pathologyoutlines.com] PMID 16424867 High incidence of Hox11L2 expression in children with T-ALL.[atlasgeneticsoncology.org]

  • Lymphoma

    ., Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies[degruyter.com]

  • 1p32-p31 Deletion Syndrome

    PMID 16424867 High incidence of Hox11L2 expression in children with T-ALL.[atlasgeneticsoncology.org] The t(5;14)(q35.1;q11.2) disrupts the TLX3(HOX11L2) by translocating to [email protected] t(7;14)(p15.1;q11.2) .[atlasgeneticsoncology.org] In most instances, the t(5;14) results in the activation of the TLX3(HOX11L2) homeobox gene at 5q35.1.[atlasgeneticsoncology.org]

  • Acute Lymphoblastic Leukemia

    These translocations lead to disruption of the TCR partner gene, the most common being the HOX11 and HOX11L2 genes.[cancertherapyadvisor.com]

  • Aleukemic Leukemia

    These translocations lead to disruption of the TCR partner gene, the most common being the HOX11 and HOX11L2 genes.[cancertherapyadvisor.com]

  • Childhood Acute Lymphoblastic Leukemia

    ., TAL1, LMO1 and LMO2, LYL1, TLX1/HOX11, and TLX3/HOX11L2) to one of the T-cell receptor loci and resulting in aberrant expression of these transcription factors in leukemia[cigna.com] Baak U, Gökbuget N, Orawa H, et al.: Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience[cigna.com] Cavé H, Suciu S, Preudhomme C, et al.: Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell[cigna.com]

  • Acute Biphenotypic Leukemia

    ., TAL1, LMO1 and LMO2, LYL1, TLX1/HOX11, and TLX3/HOX11L2) to one of the T-cell receptor loci and resulting in aberrant expression of these transcription factors in leukemia[northshore.org] Baak U, Gökbuget N, Orawa H, et al.: Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience[northshore.org] Cavé H, Suciu S, Preudhomme C, et al.: Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell[northshore.org]

  • B-Precursor Acute Lymphoblastic Leukemia

    .: Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies[cancer.gov] [PUBMED Abstract] Baak U, Gökbuget N, Orawa H, et al.: Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression[cancer.gov]

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