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50 Possible Causes for HOXA, cluster, proteins

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  • Hand-Foot-Genital Syndrome

    This deletion included the entire HOXA cluster in addition to the SKAP2 and EVX1 genes.[ncbi.nlm.nih.gov] This is the largest (32 residues) polyalanine tract so far described for any polyalanine mutant protein.[ncbi.nlm.nih.gov] […] syndrome: a case report, literature review and proposal of a minimum region for this phenotype. ( 29177010 ) Yokoyama E....FrA-as S. 2017 4 Familial deletion of the HOXA gene cluster[malacards.org]

  • T-cell Acute Lymphoblastic Leukemia

    HOXA-positive group (5-year overall survival 31.2% in HOXA-positive early thymic precursor versus 66.7% in HOXA-positive non-early thymic precursor, P 0.03), but not in HOXA-negative[ncbi.nlm.nih.gov] CONCLUSIONS: We report a novel translocation in T-cell ALL highlighting the involvement of ETV6 and potentially the HOXD gene cluster in a case of T-cell ALL.[ncbi.nlm.nih.gov] * Neoplasm Proteins/biosynthesis Neoplasm Proteins/genetics Nuclear Proteins/antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* Protein[ncbi.nlm.nih.gov]

  • Polyploidy

    Bichir HoxA cluster sequence reveals surprising trends in ray-finned fish genomic evolution. Genome Res. 14 , 11–17 (2004) 31 Vandepoele, K., De Vos, W., Taylor, J.[doi.org] […] energy transfer (LET) radiation, carbon-ion radiation has been proved to induce high frequency of more complex DNA damages, including DNA double strands (DSBs) and non-DSB clustered[ncbi.nlm.nih.gov] […] had different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins[ncbi.nlm.nih.gov]

  • B-Cell Chronic Lymphocytic Leukemia

    The activation of HOXA genes is thus achieved by mechanisms other than simple H3K4 methylation.[dx.doi.org] CD19 and CD19dim clusters were included, and CD19– clusters were excluded from subsequent analyses.[doi.org] Different pathways were assessed for activation/expression of key signaling proteins. Data obtained were validated by Western blotting and confocal microscopy.[ncbi.nlm.nih.gov]

  • Vitamin A Deficiency

    In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′RARE) . Development 124 , 399–410 (1997). 166. Marshall, H. et al.[doi.org] DESIGN: In a cluster-randomized trial in children aged 6-35 mo in Western Kenya, 60 villages were randomly assigned to either intervention or control groups.[ncbi.nlm.nih.gov] Retinol, bound to its carrier retinol-binding protein (RBP), is filtered at the glomerulus and reabsorbed at the proximal tubule.[ncbi.nlm.nih.gov]

  • Malignant Glioma

    In this study, we revealed the role of the long non-coding RNA HOXA cluster antisense RNA 2 (HOXA-AS2) in malignant glioma behaviors and VM formation.[ncbi.nlm.nih.gov] Citrullinated proteins were identified by mass spectrometry.[ncbi.nlm.nih.gov] Read more Research-Human-Clinical Studies Vidian Neurectomy for Management of Chronic Cluster Headache The authors present an alternative method of sphenopalatine ganglion[journals.lww.com]

  • Brachydactyly Type E

    Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem.[genecards.org] Conclusions: Possible positional candidate genes in the one-lod support interval of this QTL include TWIST and the HOXA1-A13 cluster.[uthscsa.influuent.utsystem.edu] , Nucleic Acid/genetics* Toes/abnormalities* Translocation, Genetic* Substances PTHLH protein, human Parathyroid Hormone-Related Protein ADAM Proteins ADAMTS7 Protein ADAMTS7[ncbi.nlm.nih.gov]

  • Pure Hair and Nail Ectodermal Dysplasia

    Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem.[genecards.org] Autosomal-recessive PHNED has previously been mapped to chromosomal region 12q12-q14.1, which contains the type II hair keratin and HOXC clusters.[ncbi.nlm.nih.gov] HOXC gene cluster is located near keratin type II gene cluster.[bmcmedgenet.biomedcentral.com]

  • Chronic Lymphocytic Leukemia

    The activation of HOXA genes is thus achieved by mechanisms other than simple H3K4 methylation.[dx.doi.org] CD19 and CD19dim clusters were included, and CD19– clusters were excluded from subsequent analyses.[doi.org] […] of Bcl-2 family proteins was a major breakthrough in identifying specific Bcl-2 antagonists.[ncbi.nlm.nih.gov]

  • Glioblastoma Multiforme

    […] gene locus on chromosome 7 and the mean expression of the HOXA genes was observed in a set of 60 glioblastoma (Pearson correlation coefficient r 0.27; P .03; manuscript in[jco.ascopubs.org] Thus, protein kinases are a growing drug target class for cancers including glioblastoma.[ncbi.nlm.nih.gov] While a family clustering of GBM has long been acknowledged, relevant hereditary factors still remained elusive.[ncbi.nlm.nih.gov]