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9 Possible Causes for HSP70 HOM

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  • Duodenal Ulcer

    -2 1267 and HSP70-Hom 2437 by RFLP.[ncbi.nlm.nih.gov] This study addresses the possible association between the HSP70-2 1267 and HSP70-Hom 2437 polymorphisms and the risk of developing gastric cancer in a high-risk population[ncbi.nlm.nih.gov] Persons with C carrier genotypes of HSP70-Hom were significantly less susceptible to gastric cancer than those with the TT genotype (OR 0.29; 95% CI 0.09-0.87; p 0.027).[ncbi.nlm.nih.gov]

  • Abacavir

    […] narrowed the putative susceptibility region to the Hsp70-Hom locus.[pnas.org] Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant . Proc Natl Acad Sci USA 2004; 14 : 335–342. 6.[nature.com] Several lines of evidence strongly suggest the involvement of both Hsp70-Hom and HLA-B*5701 .[pnas.org]

  • Familial Isolated Arrhythmogenic Right Ventricular Dysplasia 10

    HSP70-hom 2437T/C HSP70-hom 2437T/C is a missense mutation Met-439Thr, which may affect HSP70-hom protein folding and subsequent other protein foldings in the cell.[ommegaonline.org] […] role of HSP70-1 and HSP70-hom polymorphism of the HSP70 gene family.[ommegaonline.org] HSP70 gene family consists of three variants viz HSP70-1, HSP70-2 and HSP70-hom and is mapped to the MHC class III region on chromosome 6 p23.1.[ommegaonline.org]

  • Familial Isolated Arrhythmogenic Right Ventricular Dysplasia

    HSP70-hom 2437T/C HSP70-hom 2437T/C is a missense mutation Met-439Thr, which may affect HSP70-hom protein folding and subsequent other protein foldings in the cell.[ommegaonline.org] […] role of HSP70-1 and HSP70-hom polymorphism of the HSP70 gene family.[ommegaonline.org] HSP70 gene family consists of three variants viz HSP70-1, HSP70-2 and HSP70-hom and is mapped to the MHC class III region on chromosome 6 p23.1.[ommegaonline.org]

  • Ankylosing Spondylitis

    Polymorphic analysis of the human MHC-linked heat shock protein (HSP70–2) and HSP70-HOM genes in insulin-dependent diabetes mellitus (IDDM).[siicsalud.com] Polymorphism of the heat-shock protein gene HSP70-2 in SLE. Br J Rheumatol 1995;34:721–3. Pociot F, Ronningen KS, Nerup J.[siicsalud.com]

  • Sarcoidosis

    Polymorphisms in the HSPA1L (alias HSP70-hom) have been associated with susceptibility to rheumatoid arthritis [ 85 ].[intechopen.com] Antibodies to HSP70 in sarcoidosis have been reported [ 86 , 87 ].[intechopen.com]

  • Hypersensitivity

    Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant. Proc Natl Acad Sci U S A 2004 ;101: 4180 - 4185 10.[nejm.org]

  • Distal Myopathy Type Welander

    Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B’, and HSPA5/BiP/GRP78 .[nature.com]

  • Myosin Storage Myopathy

    Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B’, and HSPA5/BiP/GRP78 .[nature.com]

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