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1,130 Possible Causes for Histocompatibility, Locus,, Minor

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  • Streptococcal Infection

    Association of the GNAS locus with severe malaria Functional studies have demonstrated an interaction between the stimulatory G protein alpha subunit (G-alpha-s) and the malaria[well.ox.ac.uk] This activity is attributed to the ability of the superantigen to simultaneously bind to the V-beta region of the T-cell receptor and to class II major histocompatibility[emedicine.medscape.com] Transient hypocomplementemia and complete recovery are typical, with only a minority developing chronic disease.[ncbi.nlm.nih.gov]

  • Influenza

    Fig. 1 captures the essential features of our model for a two-locus system with two alleles ( a and b ) at one locus and two alleles ( x and y ) at the other.[doi.org] Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8 T cells. J. Exp. Med. 174 : 875 -880.[doi.org] Minor differences in the side chain length as well as lipophilicity appeared to have significant impact on antiviral activity and cytotoxicity.[ncbi.nlm.nih.gov]

  • Osteoporosis

    In the patient and control groups, the genotype distribution of the studied locus was found to be non-compatible with Hardy-Weinberg equilibrium.[ncbi.nlm.nih.gov] Chronic Hepatitis -- Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders -- Section 1: The Immune System in Health and Disease -- Chapter 343: The Major Histocompatibility[worldcat.org] Fixed, 95% CI) 1.56 [1.15, 2.11] 2 GI minor overall 2 years Show forest plot 4 536 Peto Odds Ratio (Peto, Fixed, 95% CI) 1.04 [0.71, 1.51] 3 GI minor overall 4 years Show[doi.org]

  • Infectious Mononucleosis

    Markers in the HLA class I locus, including the SNPs rs2530388 and rs6457110, were recently found to be associated with risk of EBV-related HL ( 14 , 15 ).[dx.doi.org] Sreeram V Ramagopalan, Julian C Knight and George C Ebers , Multiple sclerosis and the major histocompatibility complex , Current Opinion in Neurology , 10.1097/WCO.0b013e32832b5417[dx.doi.org] The majority of cases reviewed had no preceding trauma, although previous studies have suggested this may be so minor as to go unnoticed by the patient.[ncbi.nlm.nih.gov]

  • Idiopathic Pulmonary Fibrosis

    We examined human leukocyte antigen (HLA) alleles in both families, including antigens Class I (locus A, B, and C) and Class II (locus DR).[ncbi.nlm.nih.gov] However, after multivariate stepwise regression leaving only significant covariates in the equation (CPI), the minor T allele was associated with a longer time to decline[doi.org] In 2000, the American Thoracic Society (ATS) and European Respiratory Society (ERS) jointly agreed major and minor criteria for the diagnosis of IPF in the absence of a surgical[radiopaedia.org]

  • Adrenal Insufficiency

    Generally speaking, steroid doses should be doubled or tripled for a few days for fevers greater than 100.5 F, flu-like illnesses, or minor injuries.[ccpd.ucsf.edu] […] in the steroid acute regulatory protein (ie, STAR protein) (OMIM 201710 ) [25] or a mutation in the cholesterol side-chain cleavage gene (at the cytochrome P450 [CYP] 11A locus[emedicine.com] […] is a leading cause of AI. 37 The human leukocyte antigen genotype DR3/4-DQB1*0302 has been associated with type 1 diabetes and AI, and the allele frequency of the major histocompatibility[endocrinefacts.org]

  • Meningitis

    A small minority of individuals who pick up N. meningitidis develop invasive infection after an incubation period which is typically one to 10 days, although this usually[irishtimes.com] Rapid and fatal meningococcal disease due to a strain of Neisseria meningitidis containing the capsule null locus. Clin. Infect.[ncbi.nlm.nih.gov] There are potential risks of disease reactivation, and preclinical animal data may be difficult to interpret since the human major histocompatibility complexes are quite different[dx.doi.org]

  • Thalassemia Minor

    Molecular analysis of the human beta-globin locus activation region . Proc Natl Acad Sci U S A 1989 ;86:5439–5443.[doi.org] Scholar Kremastinos DT, Flevari P, Spyropoulou M, Vrettou H, Tsiapras D, Stavropoulos-Giokas CG: Association of heart failure in homozygous beta-thalassemia with the major histocompatibility[doi.org] Abstract This report describes the findings of a screening program of 918 obstetric patients for thalassemia minor.[ncbi.nlm.nih.gov]

  • Immunodeficiency due to Defective Expression of HLA Class 1

    The mutated genes that produce the CVID phenotype are known only for a minority of patients, and they are diverse in their influence on immune function and include ICOS (inducible[doi.org] Detection of maternal DNA in placental/umbilical cord blood by locus-specific amplification of the noninherited maternal HLA gene. Blood. 1996;88:1494–500. [PubMed] 7.[annsaudimed.net] Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med 2, 338 –342.[jgv.microbiologyresearch.org]

  • Beta Thalassemia

    (Also known as/Synonyms) Alpha Thalassemia Minor Anemia Hemolytic Thalassemia Minor Delta-Beta Thalassemia Minor What is Beta Thalassemia Minor?[dovemed.com] In addition to the variation of the phenotype resulting from allelic heterogeneity at the beta globin locus, the phenotype of beta-thalassemia could also be modified by the[ncbi.nlm.nih.gov] Association of heart failure in homozygous beta-thalassemia with the major histocompatibility complex . Circulation . 1999 ; 100 :2074–2078.[circheartfailure.ahajournals.org]