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91 Possible Causes for Hydroxymethylglutaryl CoA, Synthase

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  • Smith Lemli Opitz Syndrome

    We hypothesized that i) 7DHC and 8DHC accumulation contributes to the poor outcome of SLOS patients and ii) blood exchange transfusions with hydroxymethylglutaryl (HMG)-CoA[ncbi.nlm.nih.gov] HMG-CoA synthase and squalene synthase activities in the patient were upregulated to 149% and 532%, respectively, while the activity of HMG-CoA reductase, the rate-limiting[ncbi.nlm.nih.gov] , HMG-CoA reductase, squalene synthase and 7-dehydrocholesterol delta7-reductase in liver specimens from a patient with SLOS and 11 controls.[ncbi.nlm.nih.gov]

  • Progeria

    Agents Physiological Effects of Drugs Anticholesteremic Agents Hypolipidemic Agents Antimetabolites Molecular Mechanisms of Pharmacological Action Lipid Regulating Agents Hydroxymethylglutaryl-CoA[clinicaltrials.gov] KEYWORDS: ATP synthase, H transporting, mitochondrial F0 complex, subunit B1; ATP synthase, H transporting, mitochondrial F1 complex, O subunit; ATP synthase, H transporting[ncbi.nlm.nih.gov] This study identified several compounds, called monoaminopyrimidines, which target two key enzymes of the farnesylation process, farnesyl pyrophosphate synthase and farnesyl[ncbi.nlm.nih.gov]

  • Hypercholesterolemia

    Hyperlipidemia, Statins Keywords: ACC Publications, Cardiology Magazine, Cholesterol, Cholesterol, LDL, Coronary Artery Disease, Death, Sudden, Cardiac, Genetic Testing, Hydroxymethylglutaryl-CoA[acc.org] We examined the expression of cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES1), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 using[ncbi.nlm.nih.gov] Hypercholesterolemia, Hypertriglyceridemia, Lipid Metabolism, Nonstatins, Novel Agents, Primary Hyperlipidemia, Statins, Hypertension Keywords: Pregnancy, Hyperlipoproteinemia Type II, Hydroxymethylglutaryl-CoA[acc.org]

  • Idiopathic Inflammatory Myopathy

    […] and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 21 Hydroxymethylglutaryl-CoA[malacards.org] […] reductase (complex I and III) succinate dehydrogenase (complex II), succinate cytochrome c reductase (complex II and III), cytochrome c oxidase (complex IV), and citrate synthase[ncbi.nlm.nih.gov]

  • Cardiac Hypertrophy

    Factor A/metabolism Ventricular Function, Left/drug effects Ventricular Remodeling Substances Fatty Acids, Monounsaturated HSP90 Heat-Shock Proteins HSP90alpha protein, rat Hydroxymethylglutaryl-CoA[ncbi.nlm.nih.gov] […] is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases[ncbi.nlm.nih.gov] […] prohypertrophic effects of CCR9 were not attributable to the mitogen-activated protein kinase signaling pathway but rather to the AKT-mammalian target of rapamycin-glycogen synthase[ncbi.nlm.nih.gov]

  • Ezetimibe

    Hydroxymethylglutaryl-CoA reductase inhibitor (statin) therapy is recommended as first-line treatment in diabetic patients with elevated LDL cholesterol levels ( 2 , 3 ).[care.diabetesjournals.org] Phosphorylation levels of glycogen synthase kinase-3p (p-GSK-3P) and Akt (p-Akt), as well as total GSK-3p and Akt were determined by Western blotting.[ncbi.nlm.nih.gov] Aortic Valve Stenosis, Atherosclerosis, Azetidines, Bile, Cholesterol, Cholesterol, Dietary, Cholesterol, LDL, Cytochrome P-450 Enzyme System, Enterohepatic Circulation, Hydroxymethylglutaryl-CoA[acc.org]

  • Pravastatin

    It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).[reference.md] NO release and inducible nitric oxide synthase expression was significantly reduced in both treatment groups.[ncbi.nlm.nih.gov] We monitored the secretion of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng), endothelial nitric oxide synthase (eNOS[ncbi.nlm.nih.gov]

  • Cerivastatin

    Cerivastatin, a hydroxymethylglutaryl CoA reductase inhibitor; pyrrolidinedithiocarbamate; or curcumin was found to completely prevent the AGE-induced increase in NF-kB and[ncbi.nlm.nih.gov] CONCLUSION: Cerivastatin increases FVR responses to ACH in type 2 diabetic men with mild dyslipidaemia but only following NO synthase inhibition.[ncbi.nlm.nih.gov] […] coenzyme A (HMG CoA) in the liver - the rate limiting step in cholesterol synthesis (approximately 50% of circulating cholesterol is endogenously synthesised, the remainder[gpnotebook.co.uk]

  • 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency

    Hydroxymethylglutaryl-CoA-Lyase Hydroxymethylglutaryl-CoA-Lyase (kurz: HMG-CoA-Lyase oder HL ) ist das Enzym , das die Spaltung von HMG-CoA in Acetyl-CoA und Acetoacetat katalysiert[de.academic.ru] Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency Johannes Zschocke MD PhD (Dr.[medlink.com] Proteins Hydroxymethylglutaryl-CoA lyase (HMGCL) Hydroxymethylglutaryl-CoA lyase (HMGCL) UniProt Number: P35914 Alternate Names: HMG-CoA lyase, HL, 3-hydroxy-3-methylglutarate-CoA[mitosciences.com]

  • Fluvastatin

    Factor A/metabolism Ventricular Function, Left/drug effects Ventricular Remodeling Substances Fatty Acids, Monounsaturated HSP90 Heat-Shock Proteins HSP90alpha protein, rat Hydroxymethylglutaryl-CoA[ncbi.nlm.nih.gov] METHODS: We investigated the effects of fluvastatin on endothelial nitric oxide synthase (eNOS) phosphorylation and expression, as well as terahydrobiopterin (BH4) metabolism[ncbi.nlm.nih.gov] We show that the promoter activity of prostacyclin synthase (PTGIS), the mRNA expression of PTGIS and endothelial nitric oxide synthase (eNOS), and the production of PGI2[ncbi.nlm.nih.gov]

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