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50 Possible Causes for ICOS L

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  • Pulmonary Sarcoidosis

    KEYWORDS: ICOS; ICOS-L; Löfgren's syndrome; regulatory T cells; sarcoidosis[] We propose a potential implication of the ICOS/ICOS-L immune-regulatory axis in disease activity and resolution and suggest to evaluate further the suitability of ICOS as[] Moreover, blood monocytes from LS patients revealed increased ICOS-L levels compared to healthy donors.[]

  • Allergic Asthma

    IFNγ stimulates human cord (neonatal) blood basophils to increase their expression of major histocompatibility complex (MHC) class II and inducible costimulatory-ligand (ICOS-L[]

  • Sjogren's Syndrome

    Other biological agents being studied in primary SS include anti-CD40, anti-ICOS-L, anti-BAFF-R and Pi3Kinase inhibitors.[] Drug name Target of action CFZ 533 Anti-CD 40 monoclonal antibody AMG 557/ MEDI587 Anti-ICOS-L monoclonal antibody Tocilizumab Anti-IL6 VAY 736 Anti-BAFF-R monoclonal antibody[]

  • Neutrophil Immunodeficiency Syndrome

    Inducible kostimulatorisches Molekül ICOS-L Auf B-Zellen exprimierter Ligand für ICOS IFN-γR1 Interferon-γ-Rezeptor 1 IFN-γR2 Interferon-γ-Rezeptor 2 Igα Teil des B-Zell-Rezeptorkomplexes[] Transkriptionsfaktor in der Myelopoese GvH Graft-versus-host-Reaktion (Spenderlymphozyten gegen Empfänger-Reaktion) HAE Hereditäres Angioödem HUS Hämolytisch-urämisches Syndrom ICOS[]

  • Autoimmune Necrotizing Myopathy

    Because both BB1 and ICOS-L are functional molecules induced by interferon-( or TNF-( on human myoblasts [ 62 ], the BB1/CD28 and ICOS/ICOS-L interactions in PM and sIBM denote[] Stimulation is supported and enhanced by the engagement of costimulatory molecules BB1, ICOS and CD40 on the muscle fibers and their ligands CD28, CTLA-4, ICOS-L and CD40L[] A pre-requisite for the immunological synapse is the presence of the B7 family of costimulatory molecules [B7-1, B7-2, BB or inducible-costimulator-ligand (ICOS-L)] on the[]

  • Chronic Lymphocytic Leukemia

    Duran i Reynals, IDIBELL, L' Hospitalet de Llobregat, Barcelona, Spain. 9 Servicio de Hematología, Hospital Universitario de Salamanca, Spain; IBMCC, Centro de Investigación[] […] d'Hematologia, Hospital del Mar, Barcelona, Spain. 7 Unitat de Citogenètica, Laboratori Clínic ICS, Hospital Universitari Arnau de Vilanova, Lleida, Spain. 8 Hematología Clínica, ICO-Hospital[]

  • Hyper-IgM Syndrome with Susceptibility to Opportunistic Infections

    ICOS is expressed by activated T cells, and interacts with ICOS-ligand (ICOS-L) expressed by B lymphocytes.[] Finally, a few patients with CVID carry mutations in the inducible T-cell costimulator ( ICOS ) gene.[]

  • Graft-versus-Host-Disease

    ICOS-L pathways (recently reviewed by Briones et al 26 ).[] Many costimulatory ligand/receptor interactions and their involvement in aGVHD have been described, including the B7/CD28/CTLA4, CD30/CD30L, CD40/CD40L, OX40/OX40L, and ICOS[]

  • Familial Temporal Epilepsy

    […] inducible T cell co-stimulator AILIM CCLP CRP-1 H4 Ly115 Icosl icos ligand AU044799 B7-H2 B7RP-1 B7h BG071784 GI50 GL50 GL50-B ICOS-L Icoslg LICOS Ly115l mKIAA0653 Id1 inhibitor[] B230343B06Rik Narg2 Ick intestinal cell kinase 2210420N10Rik AI848300 Mrk Icmt isoprenylcysteine carboxyl methyltransferase 1700008E11Rik C80758 Gm13095 HSTE14 PPMT STE14 pcCMT Icos[]

  • Progressive Familial Intrahepatic Cholestasis 4

    Hipobil irrubinemia Tiene escaso interés c l ín ico y puede observarse en las anemias aplási- cas o ferropénicas intensas.[] . - Pancreat i t is aguda y crónica , pseudoquis te pancreát ico. - Es tenosis bi l iar postquirúrgica. - Malformaciones congénitas: atresia biliar, quistes coledocianos ,[] Pancreat i t i s aguda: se p roduce un aumento l igero-moderado, pr inc i - pa lmente a expensas de la GOT, y es un factor pronóst ico de gravedad cuando supera los 2 5 0[]

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