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1,880 Possible Causes for IFN

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  • Viral Lower Respiratory Infection

    S3 A ) without causing any nonspecific or constitutive activation of the IFN system ( SI Appendix , Fig. S3 B ).[pnas.org] This in turn initiates a signaling cascade that results in type 1 IFN production and activation of antiviral genes ( 23 ).[pnas.org] Functional testing of the variants IFIH1 alleles demonstrated that the resulting proteins are unable to induce IFN-β, are intrinsically less stable than wild-type IFIH1, and[pnas.org]

  • Influenza

    NS1 further inhibits the activation of IFN-induced antiviral genes.[genome.jp] […] the activity of ISG15 ( 27 ), an IFN-inducible protein that enhances the IFN-mediated antiviral response.[doi.org] DOI PubMed Proietti E , Bracci L , Puzelli S , Di Pucchio T , Sestili P , DeVincenzi E , Type I IFN as a natural adjuvant for a protecvie immune response: lessons from the[doi.org]

  • Urinary Tract Infection

    Furthermore, MrpA in fusion form with FliC significantly increased the systemic, mucosal and IFN-γ responses of the FliC alone.[ncbi.nlm.nih.gov] The addition of FliC as adjuvant to MrpA in fusion form significantly raised the mucosal IgA and cellular (IFN-γ and IL-17) responses and maintained the serum IgG responses[ncbi.nlm.nih.gov]

  • Sinusitis

    […] found, while in neutrophilic chronic rhinosinusitis, more often associated with chronic rhinosinusitis without polyps, neutrophils predominate, with elevated interferon (IFN[doi.org]

  • Infectious Mononucleosis

    Prominent among these is IFN-γ. IFN-γ is produced by activated T cells and NK cells.[doi.org] Lünemann and Christian Münz , Impaired IFN-γ production and proliferation of NK cells in Multiple Sclerosis , International Immunology , 23 , 2 , (139) , (2011) .[dx.doi.org] Cells from the patient's father showed similar elevations in some (IL-4, IL-13), but not all (IFN-γ, IL-10) of the cytokines found to be elevated in his son.[dx.doi.org]

  • Pneumonia

    T‐lymphocytes and T‐helper, impairs macrophage function and reduced killer cells ( Ibs 2003 ; Ravaglia 2000 ), and adversely impacts innate immunity affecting interferon (IFN[doi.org]

  • Tuberculosis

    As secretion of IFN-γ in Th1 cells is induced by tuberculosis, we aimed to investigate the role of anti-IFN-γ antibody on the differentiation and activation of osteoclasts[ncbi.nlm.nih.gov] Mycobacterium tuberculosis inhibits IFN-γ transcriptional responses without inhibiting activation of STAT1. J.[ncbi.nlm.nih.gov] Current evidence, reviewed extensively elsewhere ( 5 – 10 ), on the performance of IFN-γ assays suggests that RD1-based IFN-γ assays have higher specificity, better correlation[dx.doi.org]

  • Meningitis

    Log IFN-γ was independently associated with a more rapid fall in CFU (increase in rate of fall in CFU for each increment in log IFN-γ 0.15 log CFU/ml CSF/day (95%CI, 0.08–[dx.doi.org] […] in the clearance of cryptococci from the CSF 24 support further work on the dosing and scheduling of adjunctive recombinant IFN-γ.[dx.doi.org] Fig. 1 Association between CSF IFN-γ levels and rate of clearance of infection in cryptococcal meningitis (from reference 24, with permission).[dx.doi.org]

  • Idiopathic Pulmonary Fibrosis

    The authors investigated the pathogenesis of MHV-68 infection in IFN-γ receptor knockout (IFN-γR –/– ) mice.[doi.org] The study showed no benefit from IFN- γ as measured by the primary endpoint.[doi.org] IFN-γR –/– mice were intranasally infected with MHV-68 and euthanized between 15 and 180 days postinfection.[doi.org]

  • Recombinant Interferon Gamma

    We have identified a region of high homology to the interferon gamma (IFN-gamma) of other mammals within the recently published armadillo whole genomic sequence. cDNA was[ncbi.nlm.nih.gov] IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions.[mybiosource.com] Product Name Interferon gamma (IFN-gamma) Recombinant (IFNG), Recombinant Protein Popular Item Also Known As Human Interferon-gamma, Recombinant Research Use Only For Research[mybiosource.com]

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