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178 Possible Causes for KINASE, TP53 REGULATING

  • Premature Aging

    The relationship between myocardial senescence and Pim kinases deserves attention because Pim-1 kinase is cardioprotective, in part, by preservation of mitochondrial integrity[ncbi.nlm.nih.gov] Moreover, these cellular phenotypes were accompanied by an up-regulation of TXNIP and TP53 transcriptional expression.[ncbi.nlm.nih.gov] As SB203580 is known to inhibit other kinases in addition to p38, this suggests that more than one kinase pathway is involved.[ncbi.nlm.nih.gov]

  • Alveolar Rhabdomyosarcoma

    Protein kinase C iota (PKCι) has been shown to have an important role in tumorigenesis of many cancers, but little is known about its role in rhabdomyosarcoma.[ncbi.nlm.nih.gov] Sphingosine exerts antiproliferative and pro-apoptotic effects via MYCN down-regulation independently of TP53 mutation status in PAX3-FOXO1-positive ARMS cells.[ncbi.nlm.nih.gov] In vitro kinase assays revealed that Cdk4 directly phosphorylated PAX3-FOXO1 at Ser(430).[ncbi.nlm.nih.gov]

  • Osteosarcoma

    Our result further demonstrated that the overexpression of S-phase kinase-associated protein 2 (Skp2) was closely involved in the resistance of OS cells to MTX and in the[ncbi.nlm.nih.gov] Our findings suggest that LAMP3 promotes OS cell viability and survival by regulating TP53 expression.[ncbi.nlm.nih.gov] BACKGROUND The present work was performed to detect the potential inhibitory effect of cyclic guanosine monophosphate (cGMP)-dependent protein kinase II (PKG II) on epidermal[ncbi.nlm.nih.gov]

  • Aristolochic Acid

    Since mitogen-activated protein kinases play an important role in cell survival, death and cell cycle progression, we assayed their function in AA-treated renal tubular epithelial[ncbi.nlm.nih.gov] More detailed studies have shown this compound to up-regulate GADD 45β, NAIP genes and down-regulate TP53, PARP1, ERCC1, OGG1/2, MGMT, and ERCC2 genes.[scbt.com] Both the upstream kinases of JNK including MEKK4, MKK4, and MKK7, and the downstream transcription factor of JNK, AP-1, may also participate in this process.[ncbi.nlm.nih.gov]

  • Chorioamnionitis

    CDKN1A (gene coding for p21) was up-regulated in the term in labor and preterm in labor groups compared to their nonlabor counterparts; (5) the expression of the cyclin kinase[ncbi.nlm.nih.gov] ) pathway; (3) the expression of TP53 was down-regulated in the term in labor and preterm in labor groups compared to their nonlabor counterparts; (4) the expression of CDKN1A[ncbi.nlm.nih.gov] […] term in labor and preterm in labor groups compared to their nonlabor counterparts; (5) the expression of the cyclin kinase CDK2 and cyclins CCNA2, CCNB1, and CCNE1 was down-regulated[ncbi.nlm.nih.gov]

  • Testicular Germ Cell Tumor

    […] cases has identified high rates of alterations within the TP53-MDM2 axis and a high proportion of patients with potentially actionable targets, including TP53-MDM2, PI3 kinase[ncbi.nlm.nih.gov] In addition, silencing of PSMD10 up-regulated the expression of TP53, while miR-214 over-expression resulted in PSMD10 down-regulation and TP53 up-regulation.[ncbi.nlm.nih.gov] KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain[ncbi.nlm.nih.gov]

  • Preterm Labor

    CDKN1A (gene coding for p21) was up-regulated in the term in labor and preterm in labor groups compared to their nonlabor counterparts; (5) the expression of the cyclin kinase[ncbi.nlm.nih.gov] ) pathway; (3) the expression of TP53 was down-regulated in the term in labor and preterm in labor groups compared to their nonlabor counterparts; (4) the expression of CDKN1A[ncbi.nlm.nih.gov] […] term in labor and preterm in labor groups compared to their nonlabor counterparts; (5) the expression of the cyclin kinase CDK2 and cyclins CCNA2, CCNB1, and CCNE1 was down-regulated[ncbi.nlm.nih.gov]

  • Cervical Cancer

    Cyclin-dependent kinases (CDK) are considered to be potential targets of anticancer drugs that can interrupt the uncontrolled division of cancer cells.[ncbi.nlm.nih.gov] Immunohistochemistry was utilized to evaluate the expression of glucose transporter protein-1 (GLUT-1), TP53-induced glycolysis and apoptosis regulator (TIGAR), and vascular[ncbi.nlm.nih.gov] Roscovitine (Rosc) and purvalanol (Pur) are competitive inhibitors of cyclin-dependent kinases (CDKs) by targeting their ATP-binding pockets.[ncbi.nlm.nih.gov]

  • Embryonal Carcinoma

    The Rho kinase pathway plays a key role in many early cell/tissue determination events that take place in embryogenesis.[ncbi.nlm.nih.gov] In addition, the finding that TP53 can suppress senescence has caused a re-evaluation of its functional role in regulating these outcomes.[ncbi.nlm.nih.gov] The survival compounds Y-27632, HA-1077, and H-8 all strongly inhibit the kinases ROCK and PRK2, highlighting the important role of these kinases in EC cell survival.[ncbi.nlm.nih.gov]

  • Esophageal Carcinoma

    This study aims at observing the expression of activated Src tyrosine kinase in esophageal squamous cell carcinoma (ESCC), and exploring the relationship of Src tyrosine kinase[ncbi.nlm.nih.gov] The human homologue of the murine double minute-2 gene ( MDM2 ) is a negative regulator of TP53.[spandidos-publications.com] […] to AKT serine/threonine kinase 1 and mitogen-activated protein kinase 1.[ncbi.nlm.nih.gov]

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