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2,311 Possible Causes for Lateral, hepatocyte, membrane, of, of, part, plasma

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  • Cholestasis

    KEYWORDS: Cholestasis; Donor-donor variability; Primary Human Hepatocytes; Transcriptomic[ncbi.nlm.nih.gov] Cholesterol retention can cause an increase in membrane cholesterol content and a reduction in membrane fluidity and membrane function, thereby amplifying the cholestasis.[emedicine.medscape.com] METHODS: Three patients underwent serial plasma exchange procedures to control pruritus.[ncbi.nlm.nih.gov] "This large population-based study in women with ICP found increased risks of later hepatobiliary cancer and immune-mediated diseases and a small increased risk of later cardiovascular[sciencedaily.com] Abstract Unexpected severe cholestasis is part of the presentation in some neonates with hemolytic anemia but is usually self-resolving.[ncbi.nlm.nih.gov] […] additional mutations which might explain the exceptional clinical presentation of our patient but did not find any, leading us to suspect that the above named symptoms might be part[ncbi.nlm.nih.gov] There can be nausea and vomiting and pain in the upper part of the abdomen. You may have itching.[symptoma.com]

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  • Influenza

    In rat hepatocytes, for example, TNF inhibits fatty acid oxidation; influenza B virus produces similar effects in mice.[adc.bmjjournals.com] A challenge faced by these viruses is the trafficking of viral components into and out of the nucleus through the nuclear membrane.[ncbi.nlm.nih.gov] Mean plasma ACTH levels /- SE had risen to 21 /- 4.1 pg/mL in specimens obtained from patients during convalescence.[ncbi.nlm.nih.gov] She was discharged 2 days later on a tapering dose of steroids. BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved.[ncbi.nlm.nih.gov] You may download, display, print and reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal[ncbi.nlm.nih.gov] Thirty-seven years later, this goal has not yet been achieved.[doi.org] […] that the structure of this domain brings it into close proximity to the inner membrane leaflet.[doi.org]

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  • IgG4-Related Kidney Disease

    The resulting subgraphs illustrate possible associations of hepatocyte growth factor receptor c-Met nodes, differentially expressed genes and cellular states.[test.pubpharm.de] Renal biopsy revealed membranous nephropathy with tubulointerstitial nephritis.[ncbi.nlm.nih.gov] […] lesions with IgG4-positive plasma cells were observed.[ncbi.nlm.nih.gov] Four years later, he presented to the urologist with severe left hydronephrosis because of marked thickness of the left ureter wall.[ncbi.nlm.nih.gov] -Part V. Lessons from Cases.- 26. Multicentric Castleman's Disease Mimicking IgG4-Related Disease; A Case Report.-27.[ebay.co.uk] Two radiologists reviewed in consensus the MR images to determine the distribution pattern (location, laterality, and multiplicity) and the visually assessed signal intensity[ncbi.nlm.nih.gov] Glomeruli may be affected by IgG4-RD, usually in the form of membranous glomerulonephritis.[ncbi.nlm.nih.gov]

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  • Neonatal Adrenoleukodystrophy

    Peroxisomes could not be detected in CHRS liver and kidney; however, in the NALD patient, small and sparse cytoplasmic bodies resembling altered peroxisomes were found in hepatocytes[ncbi.nlm.nih.gov] Proteins that are targeted to the membrane of the peroxisome (called peroxisome membrane proteins, PMPs) contain a consensus sequence identified as the PEX19 binding site[themedicalbiochemistrypage.org] In most cases, a severe adrenal insufficiency occurs: the adrenal glands are severely atrophied and plasma ACTH levels were markedly elevated.[ela-asso.com] These very-early-onset seizures may require unique diagnostic and therapeutic considerations, in contrast with the later onset of seizures in neonates.[ncbi.nlm.nih.gov] It is part of the Zellweger spectrum.[en.wikipedia.org] The liver is enlarged and cirrhotic and hepatocytes contain lamellar inclusions similar to phytol inclusions seen in chloroplasts of plant cells.[neuropathology-web.org] Patients have adrenal insufficiency and later become deaf and blind. Death occurs between the ages of 1 and 9 years.[aao.org]

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  • Dubin-Johnson Syndrome

    The changes in hepatocytes co-existed with marked stimulation and enhanced phagocytic activity of Kupffer cells.[ncbi.nlm.nih.gov] Intact erythrocytes and inverted erythrocyte membrane vesicles from Dubin-Johnson patients, TR-rats and appropriate controls were studied with regard to ATP-dependent transport[ncbi.nlm.nih.gov] Kinetic analysis of plasma disappearance data showed an increase in reflux and decrease in conjugation.[ncbi.nlm.nih.gov] Another isoform of MRP was detected, however, in the lateral hepatocyte membrane of the patient.[ncbi.nlm.nih.gov] Gilbert-Meulengracht disease leads to unconjugated hyperbilirubinemia because of impaired glucuronidation activity, and is part of a spectrum of genetic variants also encompassing[ncbi.nlm.nih.gov] These may result in part from the induction of multidrug-resistance protein 2 (MRP2/ABCC2) expression in the liver and kidney.[ncbi.nlm.nih.gov] This study suggests that long-term follow-up is indicated for neonatal DJS because of possible recurrence and/or second attacks of jaundice in later life, and that disruption[ncbi.nlm.nih.gov]

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  • Streptococcal Infection

    GBS-induced cell death is also a prominent feature of hepatocytes in a rabbit model of GBS sepsis ( Ring et al., 2002 ) and in neurons of the dentate gyrus in GBS meningitis[intechopen.com] GBS bacteria in pregnant women can cause urinary tract infections * as well as chorioamnionitis (kor-e-o-am-nee-on-EYE-tis, infection of the womb and membranes surrounding[humanillnesses.com] Streptokinase - a plasma activator that initiates the fibrinolytic dissolution of fibrin clots. 3. Hyaluronidase 4.[atsu.edu] We report an instance of temporally related life-threatening group A streptococcal infection in a husband and 2 weeks later in his wife.[ncbi.nlm.nih.gov] Invasive infection occurs when group A Streptococci invade parts of the body where bacteria are not normally present, including the blood and soft tissues such as muscle or[dhs.wisconsin.gov] (Study describing management aspects of severe group A streptococcal infections, including the potential utility of plasma exchange) Rodríguez-Nuñez, A, Dosil-Gallardo, S,[clinicaladvisor.com] Global Tic Severity Scale, Child Behavior Checklist for Ages 4-18, Conners Parent Rating Scale, and State-Trait Anxiety Inventory for Children at baseline and six weeks later[ncbi.nlm.nih.gov]

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  • Bile Salt

    […] in human HepG2-Ntcp and completely abolished in primary rat hepatocytes.[ncbi.nlm.nih.gov] ABCB4 and ABCB1 were mainly distributed in nonraft membranes.[ncbi.nlm.nih.gov] There appears to be species difference in the substrate specificity and the regulation of plasma membrane localization of human and rodent NTCP.[ncbi.nlm.nih.gov] We speculate that Slc10a1 is a neurosteroid transporter in skate that gained its substrate specificity for bile salts later in vertebrate evolution.[ncbi.nlm.nih.gov] Bile molecules have a hydrophobic and a hydrophilic part. The hydrophobic part is attracted towards fat while hydrophilic part is attracted towards water.[biology.stackexchange.com] BSEP transcription was markedly repressed in the later stages of pregnancy and immediately recovered after parturition, resembling the clinical course of ICP in human.[ncbi.nlm.nih.gov] Plasma bile salt levels were elevated, linked to dysregulation of bile salt synthesis and enhanced trafficking of bile salts from the liver to the systemic circulation.[ncbi.nlm.nih.gov]

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  • Progressive Familial Intrahepatic Cholestasis

    Liver histology reveals canalicular cholestasis and the absence of true ductular proliferation with only periportal biliary metaplasia of hepatocytes.[orpha.net] […] phosphatidylcholine from the inner leaflet to the outer leaflet of the canalicular membrane.[ncbi.nlm.nih.gov] Liver histology reveals portal fibrosis and true ductular proliferation with mixed inflammatory infiltrate and, at a later stage, signs of biliary cirrhosis.[orpha.net] In these children, the disease develops later in life, is less […] Continue reading " Cholestasis: SUMMARY Part 2 " Cholestasis: SUMMARY Part 1 Posted in June 10th 2012 The[depressionofspirits.com] The distinctive feature of PFIC 1 and 2 and IEBAS is a normal level of GGT, while IEBAS are suspected in patients with low plasma bile acids concentration.[ncbi.nlm.nih.gov] An infant with heterozygous M183V mutation was later born healthy in Family 1.[ncbi.nlm.nih.gov] BSEP is only expressed in hepatocytes, and extrahepatic features are not present in PFIC2.[orpha.net]

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  • Malignant Neoplasm

    […] notes that researchers six years ago reported 5 that hypoxic cancer cells ramped up production of a protein called Met, which binds and activates another protein called hepatocyte[doi.org] The epithelial differentiation was confirmed by the demonstration of keratin by immunohistochemical techniques and of basement membrane, tonofilaments, and well-formed desmosomes[ncbi.nlm.nih.gov] In this study, the plasma fraction containing AIS is shown to inhibit mouse erythroblast formation in vitro.[ncbi.nlm.nih.gov] OBSERVATION: We present the case of a 68-year-old male who presented with clinically typical seborrhoeic keratosis that later histological examination showed partially covered[ncbi.nlm.nih.gov] Hajdu , A note from history: Landmarks in history of cancer, part 4 , Cancer , 118 , 20 , (4914-4928) , (2012) . A. K. M.[doi.org] Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells. Biochem.[ncbi.nlm.nih.gov] Chlamydial inclusions in the fallopian tube epithelium were demonstrated by immunohistochemistry using a mouse monoclonal antibody to a genus-specific outer membrane lipoprotein[ncbi.nlm.nih.gov]

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  • Endocrine Dysfunction

    Finally, to establish causality, ex vivo studies utilizing a murine AT-hepatocyte cell line co-culture system was used.[ncbi.nlm.nih.gov] Microparticles (MPs) are plasma membrane fragments shed from stimulated or damaged cells that act as cellular effectors.[ncbi.nlm.nih.gov] Exchange of 84% of the patient's plasma resulted in a decrease in serum triglycerides (700 mg/dl) which was followed by a rebound to the original level in seven days.[ncbi.nlm.nih.gov] Moreover, vulnerability to the later development of such disorders can be increased by stress or adversity during development (e.g., childhood neglect, abuse, or trauma).[ncbi.nlm.nih.gov] Serum GH, androgen, and 24-hour urinary cortisol levels of patients with fibromyalgia tend to be in the lower part of the normal range, while serum levels of thyroid hormone[ncbi.nlm.nih.gov] Thorburn Nature Reviews Nephrology (2018) Cyanidin-3-glucoside enhances mitochondrial function and biogenesis in a human hepatocyte cell line Rashad Mogalli , Toshiya Matsukawa[nature.com] Abstract Evaluation for endocrine function is a pivotal part of the male infertility workup. Endocrine dysfunction may result from endogenous and exogenous sources.[ncbi.nlm.nih.gov]

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