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15 Possible Causes for MASP 3, mouse, protein

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  • Mannose-Binding Lectin Deficiency

    Immunol. (2006) [ Pubmed ] Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G.[wikigenes.org] We have generated mouse models of MBL deficiency in order to explore the molecular mechanisms of MBL function in disease and health.[ncbi.nlm.nih.gov] What is mannose binding lectin protein deficiency? Mannose-binding lectin protein (MBL) deficiency is a characterized as a deficiency within the body's immune system.[patientslikeme.com]

  • CARASIL

    -1, MASP-2, and MASP-3), 5 which are closely related to C1r and C1s.[doi.org] […] mRNAs Mouse ESTs Other mRNAs Expression and Regulation CpG Islands...[genome.ucsc.edu] The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...[ncbi.nlm.nih.gov]

  • Properdin Deficiency

    Derry JM et al. (1992) Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes. [ ] 6.[moldiag.com] Serum amyloid A , properdin , complement 3, and toll-like receptors are expressed locally in human sinonasal tissue [22] .[wikigenes.org] To better understand the dysfunctional protein on the molecular level, samples from three members of the Dutch family were analyzed by direct genomic sequencing.[ncbi.nlm.nih.gov]

  • Immunodeficiency due to Ficolin 3 Deficiency

    -2/ficolin-3 complexes in serum [ PMID 22848725 ] Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway.[snpedia.com] Models phenotype-based associations Disease phenotypes are compared with mouse phenotypes, with each mouse model contributing one point to the diagram.[mousephenotype.org] […] with FCN3 recombinant protein[mybiosource.com]

  • Primary CD59 Deficiency

    Severe pneumococcal disease is also reported in patients with MASP-2 deficiency.[emedicine.medscape.com] Also in a humanized mouse model, ATRA significantly enhanced the anti-MM effect of DARA.[learningcenter.ehaweb.org] 2 Lymphocytic Antigen CD59/MEM43 3 Human Leukocyte Antigen MIC11 3 T Cell-Activating Protein 3 MAC-Inhibitory Protein 4 CD59 Glycoprotein 3 Ly-6-Like Protein 3 CD59 Molecule[genecards.org]

  • Malpuech Syndrome

    Using MASP-3–depleted human serum, serum from 3MC patients, and Masp1/3 / mice, we found that lack of enzymatically active MASP-3, or complete MASP-3 deficiency, compromises[jimmunol.org] In mouse, the expression if CL-K1 was in craniofacial cartilage, heart, lungs, kidney and skeletal tissues.[brightkite.com] (PMID: 8018603) Sato T … Fujita T (International immunology 1994) 2 3 4 22 60 A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive[genecards.org]

  • Recurrent Neisseria Infections due to Factor D Deficiency

    -2-deficient patient as compared to MBL-deficient individuals Ficolin-3 deficiency • first case of ficolin-3 deficiency was described – recurrent respiratory infections since[slideshare.net] Related Product Information for CFD recombinant protein Background: Mouse complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is[mybiosource.com] In a mouse model of antiphospholipid-antibody associated fetal death, mice who were deficient in C3 and mice who were treated with a regulatory protein that inhibits C3 cleavage[emedicine.medscape.com]

  • Complement Component 3 Deficiency

    Models phenotype-based associations Disease phenotypes are compared with mouse phenotypes, with each mouse model contributing one point to the diagram.[mousephenotype.org] MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway.[frontiersin.org] Synonyms C3d protein Species Human Protein Type Native Specifications Source Human serum/plasma Purity 95% pure Form & Buffer Supplied as a liquid in PBS, pH 7.2.[fitzgerald-fii.com]

  • Poor Response to Eculizumab

    Omeros is preparing to initiate manufacturing scale-up of its MASP-3 antibodies in advance of clinical trials.[markets.businessinsider.com] Human ICTSESPVIDHQGTKSSKCV R QKVEGSSSHLVTFTVLPLEI Mouse ICTSGSSAASLHTSRPSRCV F QRIEGSSSHLVTFTLLPLEI Pig -------------------- - -------------------- Bovine ----------------[web.expasy.org] When tested in vitro, the mutant C5 protein did not bind eculizumab, suggesting that the mechanism for resistance in these patients is protein-drug binding disruption caused[2minutemedicine.com]

  • Immunodeficiency due to a C5 to C9 Complement Component Deficiency

    The crystal structures for the human and mouse proteins corrected the positions and connectivities of the disulfide bonds (PubMed: 30111885 ).[uniprot.org] MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway.[frontiersin.org] Properdin is the only complement protein that is X-linked. The protein is synthesized by monocytes, granulocytic cells and T-cells.[primaryimmune.org]