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892 Possible Causes for MEGAKARYOCYTES

  • Amegakaryocytic Thrombocytopenia

    Treatment leads to an increase in surface expression of the megakaryocytic/platelet-specific antigen, CD61, and causes morphological changes consistent with megakaryocytic[] CD34 cells from two of the three patients failed to differentiate into megakaryocytes.[] We present a newborn with thrombocytopenia whose initial bone marrow aspirate showed an appropriate number of megakaryocytes.[]

  • Acute Megakaryocytic Leukemia

    Abstract We analyzed the clinical and laboratory features of eight children (median age, 20 months; range, 13 months to 11 years) with acute megakaryocytic leukemia (M7) and[] However, a second bone marrow biopsy revealed morphologic features consistent with acute megakaryocytic leukemia (AMKL) with fibrosis.[] Abstract A case of acute megakaryocytic leukemia in a 13-month-old infant was encountered in whom an abnormal bone scan was associated with abnormal I-131 MIBG uptake in the[]

  • Gray Platelet Syndrome

    […] disorder and possibly associated in other diseases with platelet or megakaryocyte abnormalities.[] These granules, which are considered as the precursors of alpha-granules in normal megakaryocytes, appeared unable to mature, and their number decreased with the megakaryocyte[] In vitro differentiation of megakaryocytes was normal, whereas we observed deficiency of megakaryocyte α-granule proteins and emperipolesis.[]

  • Acute Panmyelosis with Myelofibrosis

    AMKL-MF was associated with elevated BM blast counts, decreased BM megakaryocyte count with rare megakaryocytic dysplasia and chromosome 21 abnormality.[] Particular emphasis was given to the morphologic evaluation of megakaryocytes.[] Megakaryocyte antigen (CD61) and erythroid cell antigen (GpA) were each expressed in only 1 patient.[]

  • Anagrelide

    Two to 3 thousand megakaryocytes were analyzed in each sample.[] Knockdown of TAL1 in primary megakaryocyte progenitors confirmed significant downregulation of FLI1 and megakaryocytic genes.[] […] proplatelet complexity, which were independent of the anagrelide-induced effect on megakaryocyte maturation.[]

  • Thrombocythemia 2

    , no predominance of small megakaryocytes with monolobulated nuclei Diagnostic criteria for post ET myelofibrosis : Required criteria : established diagnosis of ET per WHO[] Trephine Core The marrow is hypercellular for age with increased megakaryocytes.[] BM biopsy showing proliferation mainly of the megakaryocyte lineage with increased numbers of enlarged, mature megakaryocyte s with hyperlobulated nuclei.[]

  • Essential Thrombocythemia

    (who, 2001) A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage.[] The bone marrow examination revealed increased numbers of dysmorphic megakaryocytes with focal clustering.[] Therapy with the Janus kinase (JAK) inhibitor ruxolitinib ameliorated the thrombocytosis in TG mice and attenuated the increase in number of BM megakaryocytes and HSCs.[]

  • Primary Myelofibrosis

    OBJECTIVE: To assess the morphology of megakaryocytes in bone marrow biopsies of patients with and without JAK2 V617F mutation.[] , megakaryocyte clusters, often around marrow sinuses, loss of anchoring to the abluminal aspect of the marrow sinus with entry of whole megakaryocytes into the sinus lumen[] Importantly, expression of GATA1 effectively rescued maturation of PMF megakaryocytes.[]

  • Thrombocytosis

    (who, 2001) A chronic myeloproliferative neoplasm that involves primarily the megakaryocytic lineage.[] In ET, megakaryocytes are more sensitive to growth factors.[] Bone marrow biopsy in essential thrombocytosis showing increased megakaryocytes.[]

  • Myeloid Metaplasia

    […] of growth factors from megakaryocytes or monocytes reported in patients with agnogenic myeloid metaplasia (AMM).[] The myeloproliferation is characterized by an increased number of circulating CD34 progenitors with the prominent amplification of dystrophic megakaryocytic (MK) cells and[] Immunohistochemistry with anti-factor VIII antibody can be useful to confirm the presence of megakaryocytes.[]

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