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115 Possible Causes for Myogenic, Repressor

  • Emery-Dreifuss Muscular Dystrophy

    Abstract Electromyography (EMG) is a valuable clinical test in detection of muscle and nerve pathology and distinguishing between myogenic and neurogenic conditions from normal[ncbi.nlm.nih.gov] In a yeast two-hybrid screen, we found that emerin interacts with Btf, a death-promoting transcriptional repressor, which is expressed at high levels in skeletal muscle.[ncbi.nlm.nih.gov] […] the identification of emerin as a component of the nuclear envelope, I discuss here the available evidence that currently implicates EDMD as arising from perturbations in myogenic[ncbi.nlm.nih.gov]

  • Limb-Girdle Muscular Dystrophy

    LMNA mutations are also suggested to cause reduced myogenic differentiation potentials, implying that satellite cell nuclei in AD-EDMD/LGMD1B are likewise affected.[ncbi.nlm.nih.gov] Proteins/genetics* Repressor Proteins/metabolism Transcription, Genetic* Substances GATA Transcription Factors RNA, Messenger Repressor Proteins ZNF202 protein, human Dystroglycans[ncbi.nlm.nih.gov] […] muscles, chronic progressive and asymmetric weakness, accompanied by increased creatine kinase (CK) levels, dystrophic pathological changes and electromyography showing myogenic[ncbi.nlm.nih.gov]

  • Retinoid

    Proteins/genetics Repressor Proteins/metabolism Retinoid X Receptors/physiology* Transcription, Genetic* Substances Ligands Repressor Proteins Retinoid X Receptors[ncbi.nlm.nih.gov] In contrast, OS induces associations of "repressors" HDAC-3/5/7 with RARα to inhibit the RARα-directed miR-10a signaling.[ncbi.nlm.nih.gov] We propose that RA is a natural repressor of HIV-1.[jvi.asm.org]

  • Embryonal Rhabdomyosarcoma

    Interestingly, DNMT3B knock-down was able to commit ERMS cells towards myogenic terminal differentiation, as confirmed by the acquisition of a myogenic-like phenotype and[oncotarget.com] Mechanistically, ICN1 upregulated expression of SNAIL1, a transcriptional repressor, to increase TPC number in human ERMS and to block muscle differentiation through suppressing[ncbi.nlm.nih.gov] Non-myogenic origin of embryonal rhabdomyosarcoma [abstract].[cancerres.aacrjournals.org]

  • Fibrosarcoma

    Peritoneum Genitourinary Lymph Node/Spleen Hematopathology Gynecologic Orthopedic Endocrine Skin Gastrointestinal Soft Tissue Fibrous Tissue Fibrohistiocytic Lipomatous Myogenic[webpathology.com] Internal tandem duplication of B-cell CLL/lymphoma 6 (BCL6)-interacting co-repressor (BCOR) exon 15 has recently been described in clear cell sarcoma of kidney, central nervous[ncbi.nlm.nih.gov] Proteins/analysis* Repressor Proteins/genetics* Retrospective Studies Soft Tissue Neoplasms/chemistry* Soft Tissue Neoplasms/genetics* Soft Tissue Neoplasms/pathology Tandem[ncbi.nlm.nih.gov]

  • Medulloblastoma

    KEYWORDS: WNT; medulloblastoma; melanotic medullomyoblastoma; myogenic; pigmented[ncbi.nlm.nih.gov] […] mutants retain short cilia, and loss of Arl13b results in ligand-independent, constitutive, low-level pathway activation but prevents maximal signaling without disrupting Gli repressor[ncbi.nlm.nih.gov] This process increases the association of SuFu with Gli3, promoting the conversion of Gli3 into a repressor, which keeps Hh signalling off.[ncbi.nlm.nih.gov]

  • Synovial Sarcoma

    Abstract Detection of mechanical stress is essential for diverse biological functions including touch, audition, and maintenance of vascular myogenic tone.[ncbi.nlm.nih.gov] Proteins/analysis Repressor Proteins/biosynthesis Sarcoma, Synovial/diagnosis* Substances Biomarkers, Tumor Oncogene Proteins, Fusion Repressor Proteins SYT-SSX fusion protein[ncbi.nlm.nih.gov] […] histology Epithelioid sarcoma : can be keratin , TLE1 (30%) and have spindle cell morphology; CD34 (50%) and INI1 lost in majority Biphenotypic sinonasal sarcoma: has neural and myogenic[pathologyoutlines.com]

  • Autosomal Recessive Primary Microcephaly

    […] type 2E Autosomal dominant Emery-Dreifuss muscular dystrophy Autosomal recessive ataxia, Beauce type Autosomal recessive chorioretinopathy-microcephaly Autosomal recessive myogenic[csbg.cnb.csic.es] Whereas microcephalin is a component of the DNA damage response and a repressor of telomerase function, ASPM is required for the proper formation of a central mitotic spindle[ncbi.nlm.nih.gov]

  • Bosentan

    […] support from Actelion, Myogen, Pfizer, NITROX, NMT Medical, and AGA Medical.[circ.ahajournals.org] […] fibroblasts, ET-1 activated c-Abl and protein kinase C (PKC)-δ and induced Fli1 phosphorylation at threonine 312, leading to the decreased DNA binding of Fli1, a potent repressor[ncbi.nlm.nih.gov] Dr Galiè has received grant support from Pfizer, Actelion, Schering, Encysive, and Myogen. Dr Beghetti has received grant support from Actelion and Schering.[circ.ahajournals.org]

  • Rhabdomyosarcoma

    Drug treatment committed ERMS cells towards skeletal muscle differentiation by inducing a myogenic-like phenotype and increasing MYOD1, Myogenin and MyHC levels.[ncbi.nlm.nih.gov] TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis ( Carlson et al, 2002 ; Zhu et al, 2014 ).[nature.com] CONCLUSIONS: Erastin and RSL3 trigger ferroptosis in highly proliferating myogenic lines through a ERK pathway-dependent fashion.[ncbi.nlm.nih.gov]

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