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12 Possible Causes for N Methyltransferase,, Phosphatidylethanolamine, S Adenosylmethionine

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  • Vinblastine

    N-Methyltransferase/antagonists & inhibitors Phosphatidylethanolamine N-Methyltransferase/metabolism Phospholipase D/antagonists & inhibitors Phospholipase D/metabolism* S-Adenosylmethionine[ncbi.nlm.nih.gov] "Partial purification of an N-methyltransferase involved in vindoline biosynthesis in Catharanthus roseus." Phytochemistry, 32(3):673-678.[metacyc.org] We showed that cobalamin-induced increase in cell phosphatidylcholine production was phosphatidylethanolamine-methyltransferase-dependent.[ncbi.nlm.nih.gov]

  • Infantile Refsum Disease

    PubMed CrossRef Google Scholar Clarke S, Banfield K (2001) S-Adenosylmethionine-dependent methyltransferases. In: Carmel R, Jacobsen DW, eds.[link.springer.com] […] examples of peroxisomal disorders neonatal adrenoleukodystrophy (NALD) bile acid synthesis derived from cholesterol phospholipid modification alter phosphatidylserine and phosphatidylethanolamine[medbullets.com] PubMed Google Scholar Kerr SJ, Heady JE (1973) Purification and characterization of glycine N-methyltransferase. J Biol Chem 248: 69–72.[link.springer.com]

  • Bacillus Subtilis

    S -adenosylmethionine (SAM) is another one-carbon donor, synthesized from ATP and methionine by SAM synthetase, encoded by the essential metK gene.[pnas.org] […] subtilis DSM 3257, membranes of the I'1a strain were characterized by an increased amount of anteiso fatty acids and a ten-fold higher ratio of phosphatidylglycerol (PG)-to-phosphatidylethanolamine[ncbi.nlm.nih.gov] The key enzyme for plant Cho synthesis is phosphoethanolamine N-methyltransferase (PEAMT), which catalyzes all three methylation steps, including the rate-limiting N-methylation[ncbi.nlm.nih.gov]

  • Alcoholic Fatty Liver

    Eventually, hepatic S-adenosylmethionine and PCs become depleted in the alcoholic, with impairment of their multiple cellular functions, which can be restored by PC replenishment[ncbi.nlm.nih.gov] Dong H, Wang J, Li C, et al. (2007) The phosphatidylethanolamine N‐methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese[els.net] […] control of alcohol consumption, avoidance of obesity and of excess dietary long-chain fatty acids, or their replacement with medium-chain fatty acids, and replenishment of S-adenosylmethionine[ncbi.nlm.nih.gov]

  • Nortriptyline

    Acenocoumarol Arbutamine Atomoxetine Carbamazepine Cimetidine Dicumarol Phenprocoumon Rifapentine S-Adenosylmethionine Terbinafine Valproic Acid Other Interactions Certain[mayoclinic.org] […] prodrugs ) Acetyl-coA Adafenoxate Choline ( lecithin ) Citicoline Cyprodenate Dimethylethanolamine Glycerophosphocholine Meclofenoxate (centrophenoxine) Phosphatidylcholine Phosphatidylethanolamine[en.wikipedia.org] Possible explanations for methylation include genetic polymorphisms in cytochrome P450 metabolizing enzymes, polymorphism of amine N-methyltransferase enzyme, drug-drug interactions[ncbi.nlm.nih.gov]

  • Megaloblastic Anemia

    We assayed serum S-adenosylmethionine (SAM), SAH, total homocysteine (tHcy), and methylmalonic acid (MMA) in 15 subjects with cobalamin-deficient megaloblastic anemia and[ncbi.nlm.nih.gov] This results in decreased production of S-adenosylmethionine (SAM) needed for methylation of phosphatidylethanolamine to phosphatidylcholine for incorporation into myelin.[med-ed.virginia.edu] 5 -methyl tetrahydrofolate - Homocysteine methyltransferase deficiency Other inborn errors Hereditary orotic aciduria Lesch-Nyhan syndrome Thiamine-responsive megaloblastic[sites.google.com]

  • Scopolamine

    […] cerevisiae Saccharomyces cerevisiae SAM S -adenosylmethionine TR - 1/tr - 1 Tropinone-reductase I (enzyme/gene) TR - 2/tr - 2 Tropinone-reductase I (enzyme/gene) This is[link.springer.com] […] prodrugs ) Acetyl-coA Adafenoxate Choline ( lecithin ) Citicoline Cyprodenate Dimethylethanolamine Glycerophosphocholine Meclofenoxate (centrophenoxine) Phosphatidylcholine Phosphatidylethanolamine[en.wikipedia.org] Phytochemistry 68(4):454–463 PubMed CrossRef Google Scholar Hibi N, Fujita T, Hatano M et al (1992) Putrescine N -Methyltransferase in cultured roots of Hyoscyamus albus .[link.springer.com]

  • 2-Aminoadipic 2-Oxoadipic Aciduria

    […] spectrometry Junot et al. 2014 High resolution mass spectrometry based techniques at the crossroads of metabolic pathways Stabler et al. 2004 Quantification of serum and urinary S-adenosylmethionine[google.com] Myofosforylase deficiency N N-acetylglutamate synthase deficiency Niemann-Pick disease O Ornithine transcarbamylase deficiency Orotic aciduria P Perrault syndrome Phenylketonuria Phosphatidylethanolamine[genomediagnosticsnijmegen.nl] Glycerol kinase deficiency, adult form Glycerol kinase deficiency, infantile form Glycerol kinase deficiency, juvenile form Glycine cleavage system L protein deficiency Glycine N-methyltransferase[csbg.cnb.csic.es]

  • Beta-Ureidopropionase Deficiency

    Plasma S-Adenosylmethionine (SAM) and S-Adenosylhomocysteine (SAH) were measured at the Baylor Institute of Metabolic Diseases, Dallas,TX.[garrodsymposium.com] […] substrates for pyrimidine nucleotide salvaging, also act as the precursors of cytidine triphosphate used in the biosynthetic pathway of both brain’s phosphatidylcholine and phosphatidylethanolamine[ingentaconnect.com] Guanidinoacetat-N-Methyltransferase GAMT 19p13.3 Snyder-Robinson-S. Spermin-Synthase SMS Xp22.1 PHGDH-Def.[de.wikibooks.org]

  • Rickettsia

    The R0 genome possessed a sam gene for uptaking S-adenosylmethionine, which is conserved in all the existing Rickettsia [ 21 ].[journals.plos.org] Three of the R. peacockii pseudogenes were conserved in all genomes except REIS: n2B ATPase, HP with an N-terminal alanyl-tRNA synthetase domain (HP_N-AlaS), and phosphatidylethanolamine[jb.asm.org] The gene encoding S -adenosylmethionine synthetase ( metK ), which catalyses the biosynthesis of S -adenosylmethionine (SAM), illustrates the initiation of this process.[nature.com]