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282 Possible Causes for NF kappaB, import, into, nucleus, of, upregulation

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  • Rhus Verniciflua

    The upregulated p27Kip1 level is caused by protein stability increment by the reduction of Skp2, a key molecule related with p27Kip1 ubiquitination and degradation, and de[ncbi.nlm.nih.gov] […] to the nucleus, resulting in the upregulation of JNK phosphorylation.[ncbi.nlm.nih.gov] Consistent with the regulation of MAPKs, it was found that RVS inhibited the nuclear translocation of nuclear factor (NF)-kappaB via inhibition of the phosphorylation of IkappaB-alpha[ncbi.nlm.nih.gov] Taken together, our findings suggest that FRVE has antilipogenic potential in non-alcoholic fatty livers via AMPK upregulation.[ncbi.nlm.nih.gov] NF-kappaB regulation in the immune system. Nat Rev Immunol 2002;2:725–734. 36.[synapse.koreamed.org] Because fibroblasts are believed to play an important role in promoting the growth of breast cancer cells, we investigated the ability of butein to inhibit the clonogenic[ncbi.nlm.nih.gov]

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  • Herpes Simplex Virus 1 Infection

    Its main regulatory functions are carried out in the nucleus, but it is translocated to the cytoplasm late during HSV-1 infection.[ncbi.nlm.nih.gov] HSV-1 infection of HCECs resulted in a two-phase activation of nuclear factor-kappaB (NF-kappaB), JNK and p38, with the first peak at 1-4 hr and a second peak at 8 hr.[ncbi.nlm.nih.gov] The reported case emphasizes the importance of screening for herpes simplex virus 1.[ncbi.nlm.nih.gov] […] leading either to the productive lytic cycle or to a quiescent infection in which viral gene expression is suppressed while the viral genome is maintained in the host cell nucleus[ncbi.nlm.nih.gov] ICP0 has a nuclear localization sequence and functions in the nucleus early during infection. However, later in infection, ICP0 is found solely in the cytoplasm.[ncbi.nlm.nih.gov] Coincident with the second phase of NF-kappaB activation in HSV-1-infected HCECs, the expression of Toll-like receptor 7 (TLR7) was induced, whereas the level of TLR3 was[ncbi.nlm.nih.gov]

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  • Ehrlichia Chaffeensis

    […] glutamine transporter inhibitor (histidine), or proline analogs inhibited E. chaffeensis infection, whereas pretreatment with proline or glutamine enhanced infection and upregulated[ncbi.nlm.nih.gov] Ehrlichia chaffeensis AnkA was recently reported to be translocated into host-cell nucleus.[ncbi.nlm.nih.gov] Second, E. chaffeensis up-regulated NF-kappaB and apoptosis inhibitors and differentially regulated cell cyclins and CDK expression, which may enhance host cell survival.[ncbi.nlm.nih.gov] This animal serves as a keystone host for all life stages of the principal tick vector (Amblyomma americanum) and is perhaps the most important vertebrate reservoir host for[ncbi.nlm.nih.gov] TRP120 targeted inflammatory chemokine genes, CCL2, CCL20, and CXCL11, which were strongly upregulated during E. chaffeensis infection and were also upregulated by direct[ncbi.nlm.nih.gov] In addition to playing a role in ehrlichial binding and internalization, TRP120 translocates to the host nucleus where it is thought to function as a transcription factor[ncbi.nlm.nih.gov]

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  • Generalized Pustular Psoriasis

    RESULTS: Compared with healthy skin, GPP lesions yielded 479 and PV 854 differentially expressed genes, respectively, with 184 upregulated in both diseases.[ncbi.nlm.nih.gov] Fahr's disease (a misnomer), is characterized by symmetrical and bilateral intracerebral calcifications located in the basal ganglia with or without deposits in the dentate nucleus[ncbi.nlm.nih.gov] Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis.[ghr.nlm.nih.gov] Endogen corticosteroids inhibit proinflammatory cytokines by a feed-back mechanism and might have a great importance in the immune regulation loop.[ncbi.nlm.nih.gov] It is an important differential diagnosis of erythroderma. Epidemiology, etiology, diagnosis, and treatment options are discussed in this paper.[ncbi.nlm.nih.gov] Monitoring CD4 T lymphocyte count, preventing and correcting CD4 lymphocytopenia are important in the treatment course of juvenile GPP. 2015 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov]

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  • Hantaan Virus

    HTNV infection reduced the effect of VEGF on adhesion, migration, and the upregulation of β3 expression, but the infection alone upregulated the expression of β3 and VEGFR2[ncbi.nlm.nih.gov] Furthermore, we suggest that interferon regulatory factor (IRF)-3, as opposed to NF-κB/p65 or IRF-7, is translocated to the nucleus to induce IFN-β.[ncbi.nlm.nih.gov] […] of endogenous p65, an NF-kappaB subunit.[ncbi.nlm.nih.gov] It is one of the important target antigens that induce the CD8( ) T-cell response.[ncbi.nlm.nih.gov] Recent studies demonstrate that TLR4 expression is upregulated and mediates the secretion of several cytokines in Hantaan virus (HTNV)-infected endothelial cells.[ncbi.nlm.nih.gov] Interleukin 33 (IL-33) has been demonstrated to play an important role in physiological and pathological immune responses.[ncbi.nlm.nih.gov]

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  • Acute Lung Injury

    The present study suggests that ALI-induced upregulation of neutrophilic NOX-2/ROS may contribute to depression-like symptoms in mice. Copyright 2017 Elsevier B.V.[ncbi.nlm.nih.gov] Nrf2 upregulation and translocation into the nucleus stimulated by Sirt1 overexpression exhibited remission of histopathologic changes and enhanced CD31 expression.[ncbi.nlm.nih.gov] In addition, western blot results showed that cavidine inhibited the phosphorylation of nuclear factor-kappaB (NF-κB) p65 and IκBα induced by LPS.[ncbi.nlm.nih.gov] Therefore, the knowledge of this disorder and its dissemination, especially in our country, is important.[ncbi.nlm.nih.gov] Keratinocyte growth factor (KGF) was also upregulated after MenSCs administrated.[ncbi.nlm.nih.gov] Pulmonary edema and transfusion-related acute lung injuries are important respiratory complications seen after HSCT and in the nontransplant setting.[ncbi.nlm.nih.gov]

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  • Sophora

    Compounds 1, 3, 8, and 9 also significantly upregulated PPARγ activity in a dose-dependent manner, with EC₅₀ values of 10.5, 6.6, 15.7, and 1.6 μM, whereas compounds 1, 8,[ncbi.nlm.nih.gov] Mechanistically, sophoridine dose- and time-dependently blocks the RANKL-induced OC formation and the activation of ERK and c-Fos as well as the induction and nucleus translocation[ncbi.nlm.nih.gov] […] of IkappaB-alpha, which is an inhibitor of NF kappaB.[ncbi.nlm.nih.gov] »Import Via Watchfolder«[subshell.com] (NF-kappaB).[ncbi.nlm.nih.gov] ETHNOPHARMACOLOGICAL RELEVANCE: Sophora flavescens (Fabaceae), also known as Kushen (Chinese: ), has been an important species in Chinese medicine since the Qin and Han dynasties[ncbi.nlm.nih.gov]

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  • Croton

    It thus appears that JNK seemed to play an important role in the apoptotic activity of the active compounds.[ncbi.nlm.nih.gov] Additionally, while CMARE induced a significant upregulation of the mRNA and protein levels of Bax, those of Bcl2 did not change significantly.[ncbi.nlm.nih.gov] Cells treated with SdG (100 microg/ml) underwent apoptosis as detected by nucleus condensation and DNA fragmentation determined by ELISA, and flow cytometry.[ncbi.nlm.nih.gov] Compound 3 proved active in selectively inhibiting the induction of NF-kappaB by tumor necrosis factor-alpha in T cells.[ncbi.nlm.nih.gov] Kaurane diterpenes are considered important compounds in the development of new and highly effective anticancer chemotherapeutic agents due to their cytotoxic properties in[ncbi.nlm.nih.gov] BACKGROUND: Malaria is one of the most important tropical diseases and the greatest cause of hospitalization and death.[ncbi.nlm.nih.gov]

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  • Lonicera

    Here, we demonstrated that PELJ induced apoptosis by upregulation of DR4 and Fas, and further it is augmented by suppression of XIAP.[ncbi.nlm.nih.gov] Meanwhile, LJ counteracted nuclear factor-κB (NF-κB) activation by blocking its translocation to the nucleus.[ncbi.nlm.nih.gov] Luteolin inhibited PMA plus A23187-induced nuclear factor (NF)-kappaB activation, IkappaB degradation, and luciferase activity.[ncbi.nlm.nih.gov] CONCLUSIONS: As an important traditional Chinese medicine, further studies on Lonicera japonica can lead to the development of new drugs and therapeutics for various diseases[ncbi.nlm.nih.gov] BACKGROUND: Lonicera macranthoides is a Chinese herb that contains a large number of bioactive spanions possessing important pharmacological activities, such as anti-tumour[ncbi.nlm.nih.gov] HPLC-DAD-ESI/MS analysis showed cyanidin-3-glucoside as the major constituent among phenolics, while nutritional analysis revealed fibre, protein, calcium and magnesium as the most important[ncbi.nlm.nih.gov]

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  • Toxoplasma Gondii

    The M versus L comparison revealed 694 significantly regulated phosphopeptides (436 upregulated and 258 downregulated).[ncbi.nlm.nih.gov] Notably, the aggregates of PABPs formed upon infection are mainly found in the nucleus, which is a different response from that found after exposure to heat shock.[ncbi.nlm.nih.gov] "Heat Shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappaB and nitric oxide" J.Immunol . 169 p958-965 Kang[web.uconn.edu] In addition to being an important pathogen, T. gondii has emerged as a model for other less tractable apicomplexan parasites.[jcvi.org] TgArk1 interacts with both TgINCENPs, with TgINCENP2 being essential for its translocation to the nucleus.[ncbi.nlm.nih.gov] Due to the fact that alcohol abuse constitutes a significant social problem, searching for eliminable risk factors for addiction is extremely important.[ncbi.nlm.nih.gov]

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