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146 Possible Causes for Nalp3, human, protein

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  • Glyburide

    Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One. 4(8):e6510.[] Interestingly, genistein treatment for 48 hours did not alter BCRP protein expression in explants dissected from healthy term placentas.[] These results indicate that human fetal livers metabolize glyburide predominantly to M5 and that CYP3A7 is the major enzyme responsible for glyburide metabolism in human fetal[]

  • Folliculitis Decalvans

    Immunostaining was performed using antibodies directed against NALP1, NALP3, IL-1β, IL-8, and MxA on FD skin biopsies.[] Other causes are stress, a low protein diet, a family history, or poor nutrition. Treatment for hair loss depends on the cause.[] KEYWORDS: Cicatricial alopecia; IVIG; folliculitis decalvans; human immunoglobulin; scarring alopecia[]

  • Silicosis

    We estimated cumulative dust exposure (CDE) for all subjects and we genotyped polymorphisms in Nalp3, caspase-1, and IL-1β genes.[] Jiangsu 210009, China. 5 Department of Pharmacology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China. 6 Key Laboratory of Developmental Genes and Human[] KEYWORDS: Bone morphogenic protein-7; Epithelial–mesenchymal transition; Silica; Snail; p38 MAPK[]

  • Chronic Inflammation

    The NALP3 ( NLRP3 ) inflammasome, a mediator of IL-1β production, plays an important role in driving the innate immune response towards Aβ peptides , and blocking NALP3 activity[] ) and orphan G protein-coupled receptor 43 (GPR43) proteins compared with diabetic mice and NR-treated mice.[] Human neutrophil peptide 1 expression and influences of proinflammatory cytokines (tumor necrosis factor α, interleukin 1β, and interferon γ) were studied in human pancreatic[]

  • Mevalonate Kinase Deficiency

    In healthy subjects, alendronate alone induced the expression of NALP1 and NALP3, and then together with LPS it induced a dramatic increase in NALP3 expression.[] A further 20 variants, which are present in human genome databases, were also analysed.[] They showed that, within the cells, several proteins from the same family (known as Rab proteins) had no isoprenoid ‘tail’ – a molecule that is usually added to these proteins[]

  • Muckle Wells Syndrome

    Abstract Here, we report a case of Muckle-Wells syndrome (MWS) caused by a novel mutation in the CIAS1/NALP3 gene.[] This fascinating reference explores the scientific and human aspects of this complex field of science.[] Proteins of wild type and mutant components of NLRP3 inflammasome were expressed and purified, and the interaction abilities between these proteins were tested by surface[]

  • Cold Urticaria

    Cryopyrin, as a member of the NALP3 inflammasome, activates caspase-1, which in turn activates IL-1β.[] Results of both tests were compatible with celiac disease.A study of human leukocyte antigen indicated a high risk phenotype (HLA, DR6/DR7; DQA 0501, 0201; DQB 0301, 0201)[] The aim of the study was to assess the liberation of PF4, eosinophil cationic protein (ECP) and histamine after cold challenge in patients with CU.[]

  • Azithromycin

    NALP3 and IL-1β protein levels were determined by immunoblotting. NLRP3 gene (encoding NALP3) transcript levels were determined by quantitative qPCR.[] METHODS: Human gingival epithelial cell OBA-9 was stimulated by LPS to construct the periodontitis model, followed by the treatment of irsogladine maleate (IM) or azithromycin[] We investigated the electrophysiological effects of azithromycin in vivo and in vitro using mice, cardiomyocytes, and human ion channels heterologously expressed in human[]

  • Primary Hyperoxaluria

    NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney Int. 2013; 84 (5): 895-901[ DOI ][ PubMed ][] Abstract The functional deficit of alanine:glyoxylate aminotransferase (AGT) in human hepatocytes leads to a rare recessive disorder named primary hyperoxaluria type I (PH1[] Recent structural studies have provided important insights into the molecular recognition of cargo proteins by Pex5p.[]

  • Autoimmune Hepatitis

    Compared with merely Con A-challenged mice, those with MGL administration significantly demonstrated decreased NALP3, NLRP6, and caspase-3 expression, in which the NALP3 and[] Human but not rat liver proteins immunoblotting allowed us to characterize the novel LM antibodies and to identify CYP-2C19 as human antigen.[] The Src homology 2 adaptor protein 3 (SH2B3) gene is a member of the SH2B family of adaptor proteins that has been implicated in the integration and regulation of multiple[]