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2,714 Possible Causes for Notch, Pathway, Signaling, Wnt, and

  • T-cell Acute Lymphoblastic Leukemia

    The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth.[ncbi.nlm.nih.gov] In the present study, we assessed the effects of CCL25 on Wnt expression and the effects of Wnt5a and CCL25 on PI3K/Akt and RhoA activation.[ncbi.nlm.nih.gov] […] that individually enhanced Notch1 signaling, and when coexpressed, they synergistically increased signaling to an extent similar to that induced by core components of the Notch[ncbi.nlm.nih.gov] […] the response of T-ALL cells to Notch inhibition.[ncbi.nlm.nih.gov] Through analysis of gene expression data, we provide evidence that the hedgehog pathway is activated in 20% of T-ALL samples.[ncbi.nlm.nih.gov]

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  • Medulloblastoma

    The genetic loss of mTORC1 function inhibited HH signaling-driven growth of the cerebellum and medulloblastoma. Inhibiting translation or mTORC1 blocked HH signaling.[ncbi.nlm.nih.gov] KEYWORDS: Angiogenesis; Case report; Medulloblastoma; Wnt/β-catenin[ncbi.nlm.nih.gov] These results suggest that LncRNA LOXL1-AS1 promoted the proliferation and metastasis of medulloblastoma by activating the PI3K-AKT pathway, providing evidence that knockdown[ncbi.nlm.nih.gov] KEYWORDS: Endothelial cells; Medulloblastoma; Notch signaling pathway; Stem-like cells[ncbi.nlm.nih.gov] CONCLUSIONS: Our results suggested that the lncRNA CCAT1 promotes cell proliferation and metastasis in human medulloblastoma by possibly regulating the MAPK pathway.[ncbi.nlm.nih.gov]

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  • Osteoporosis

    The findings of the present study revealed that anti‑microRNA‑148a protected cells against ovariectomy‑induced osteoporosis through ERα by PI3K/AKT signaling.[ncbi.nlm.nih.gov] Antagonists such as sclerostin can block both BMP and Wnt signaling.[web.archive.org] Osteoporosis: assessing the risk of fragility fracture Pathway created: August 2012 Last updated: February 2018 NICE 2019.[pathways.nice.org.uk] HWE P 0.0001; MAF 1% rs2273061 800 unrelated Hong Kong Chinese females 720 Hong Kong and 17,378 of European or Asian descent BMD 5.27 10 -8 to 3.47 10 -5 JAG1 ; Wnt and Notch[doi.org] In conclusion, the results of the present study indicated that miR‑214‑5p may promote the adipogenic differentiation of BMSCs through regulation of the TGF‑β/Smad2/COL4A1 signaling[ncbi.nlm.nih.gov]

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  • Hepatoblastoma

    […] on epidermal growth factor (EGF) signaling, and to a lesser extent, on aberrant Wnt-β-catenin signaling.[ncbi.nlm.nih.gov] This effect was dependent of high baseline Wnt activity either by mutational status of β-catenin or extrinsic Wnt activation.[ncbi.nlm.nih.gov] Our aim was to elucidate the regulation and mechanism of this pathway in liver.[ncbi.nlm.nih.gov] DLK1 Delta-like 1 homolog (DLK1) belongs to the EGF -like family of proteins, and is believed to signal through the developmentally conserved Notch signaling pathway.[flipper.diff.org] Gaemers , Possible roles of DLK1 in the Notch pathway during development and disease , Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease , 1822 , 6 , (988)[doi.org]

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  • Alagille Syndrome

    Abstract Alagille syndrome is an autosomal dominant disorder with variable multisystem organ involvement that is caused by mutations in one of two genes in the Notch signalling[ncbi.nlm.nih.gov] It has been considered a genetically heterogeneous disorder of the Notch signaling pathway.[ncbi.nlm.nih.gov] ., the Jagged 1 and Notch signaling pathway) of this association. Copyright 2012 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov] Heterozygous mutations in the JAG1 gene, encoding Notch ligand Jagged1, cause Alagille syndrome (ALGS).[ncbi.nlm.nih.gov] Abstract Alagille syndrome (AGS) is a highly complex, multisystem, autosomal dominant disorder that is caused by a defect in the Notch signaling pathway.[ncbi.nlm.nih.gov]

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  • Osteosarcoma

    Melatonin inhibited of cancer stem cell by down-regulation of SOX9-mediated signaling pathway in osteosarcoma.[ncbi.nlm.nih.gov] SETD2 regulates Wnt/β-catenin signaling and its downstream gene c-myc, CD133 and cyclin D1.[ncbi.nlm.nih.gov] Licoricidin suppressed activation of the Akt and nuclear factor-kappa B (NF-κB) pathways.[ncbi.nlm.nih.gov] CCND1 showed involvement in 16 different pathways such as integrin-related kinases and Notch and were regulated by numerous miRNAs.[dx.doi.org] The expression and activation of NF-κβ Signaling relevant protein were analyzed to investigate the relationship between Akt and NF-κβ signaling after the down-regulation of[ncbi.nlm.nih.gov]

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  • Autosomal Dominant Spondylocostal Dysostosis

    It has been suggested that additional genes involved in the Notch signaling pathway may also be associated with the disease.[ivami.com] Congenital malformation hsa04310 Wnt signaling pathway H00486 Sclerosteosis Sclerosteosis is a rare sclerosing bone dysplasias inherited in autosomal recessive manner.[kegg.jp] Entry hsa04330 Pathway Name Notch signaling pathway - Homo sapiens (human) Description The Notch signaling pathway is an evolutionarily conserved, intercellular signaling[genome.jp] […] extracellular domain; NEXT, Notch external truncation; NICD, Notch intracellular domain; SCD, spondylocostal dysostosis; T-ALL, T cell acute lymphatic leukemia.[jcb.rupress.org] WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos.[ncbi.nlm.nih.gov]

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  • Vitreoretinopathy,Familial, Exudative

    The aim of this article is to first review the Wnt signaling pathway.[ncbi.nlm.nih.gov] Abstract The Wnt pathway plays important yet diverse roles in health and disease.[ncbi.nlm.nih.gov] […] employing transient transfection and reporter assays for the transcriptional activity of β-catenin, we demonstrated that RCBTB1 participates in the Norrin/FZD4 signaling pathway[ncbi.nlm.nih.gov] These findings suggest that pharmacologic activation of Wnt signaling may help treat ocular pathologies in FEVR and potentially other defective Wnt signaling-related diseases[ncbi.nlm.nih.gov] The aim of this article is to first review the Wnt signaling pathway.[ncbi.nlm.nih.gov]

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  • Bone Metastasis

    KEYWORDS: Bone metastasis; Cancer therapeutics; Osteogenesis; Osteolysis; Wnt signaling[ncbi.nlm.nih.gov] The study aims to investigate the effects of Periostin gene silencing on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer (LC).[ncbi.nlm.nih.gov] Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins.[ncbi.nlm.nih.gov] Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins . J. Cell. Biochem. 102 , 829–839 (2007). 100. Harris, S.[doi.org] In contrast, DKK1 promotes breast-to-bone metastasis by regulating canonical WNT signalling of osteoblasts.[ncbi.nlm.nih.gov]

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  • Sulindac

    RESULTS: We found that sulindac sulfide increased NF-κB signaling in HCT-15, HCT116, SW480 and SW620 cells, although the level of induction varied between cell lines.[ncbi.nlm.nih.gov] Sulindac was found to induce the apoptosis of HT-29 cells and inhibit the Wnt/β-catenin pathway.[ncbi.nlm.nih.gov] ., 1998 ), whereas proteolytic processing of Notch and nuclear translocation of truncated product are crucial steps in transduction of the Notch signaling ( Ye et al., 1999[ncbi.nlm.nih.gov] Sulindac sulfide did not activate the cGMP/PKG pathway, nor affect proliferation or apoptosis in normal colonocytes.[ncbi.nlm.nih.gov] […] mRNA and protein levels, reduced β-catenin nuclear localization, decreased T-cell factor/lymphoid enhancer factor (Tcf/Lef) promoter activity, and decreased expression of Wnt[ncbi.nlm.nih.gov]

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