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893 Possible Causes for Notch, ligand

  • Influenza

    HA ligand binds the virus to the cell to bring about infection.[ncbi.nlm.nih.gov] Step up your skincare routine with these top-notch products. Cotto chef Johnny Price shares his favourite spots.[nzherald.co.nz] Binding to different types of glycans on the array is highlighted, where magenta represents Neu5Gc, blue represents α2-8-ligands, cyan represents α2-6-ligands, green represents[doi.org]

  • Alagille Syndrome

    Abstract Alagille syndrome is an autosomal dominant disorder with variable multisystem organ involvement that is caused by mutations in one of two genes in the Notch signalling[ncbi.nlm.nih.gov] Heterozygous mutations in the JAG1 gene, encoding Notch ligand Jagged1, cause Alagille syndrome (ALGS).[ncbi.nlm.nih.gov] An antisense oligonucleotide to the Notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro. J. Biol.[dx.doi.org]

  • Skin Infection

    […] adhesion assay analysis, and time-lapse microscopy, we found the patient's T lymphocytes to express normal levels of β1 and β2 integrins but to be highly adhesive to integrin ligands[ncbi.nlm.nih.gov] The 21-year-old LSU product entered the night with just eight career points to his name but exploded for 16 points on 7 of 10 shooting to notch an obvious career high. — Forward[nesn.com] CD8( ) T-cell recruitment to skin is independent of CD4( ) T cells and interferon-γ, but requires the expression of E- and P-selectin ligands by CD8( ) T cells.[ncbi.nlm.nih.gov]

  • Osteoporosis

    […] levels of the following markers of bone turnover: Beta-Crosslaps, osteocalcin, bone alkaline phosphatase, osteoprotegerin and receptor activator for nuclear factor kappa-B ligand[ncbi.nlm.nih.gov] HWE P 0.0001; MAF 1% rs2273061 800 unrelated Hong Kong Chinese females 720 Hong Kong and 17,378 of European or Asian descent BMD 5.27 10 -8 to 3.47 10 -5 JAG1 ; Wnt and Notch[doi.org] In recent years, denosumab, a human monoclonal antibody against receptor activator of nuclear factor κB ligand (RANKL), has become widely used as an anti-osteoclastic agent[ncbi.nlm.nih.gov]

  • Dementia

    The authors show here that blocking PD-L1, a PD-1 ligand, is similarly effective, and that both treatments reversed cognitive deficiencies, and modified disease pathology[nature.com] […] of patients with AD treated with tolerable doses; this is notable in view of concerns that gamma-secretase inhibition may cause serious toxicity mediated by inhibition of Notch[doi.org] Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity .[doi.org]

  • CADASIL Syndrome

    We suggest that in CADASIL, damage to the VSMC may be associated with aberrant ubiquitin-dependent endocytosis of the Notch 3 ligand, and increased accumulation of ubiquitin[ncbi.nlm.nih.gov] Experiments in Drosophila suggest that these mutations can lead to ligand- dependent hyperactivation.[grantome.com] A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.[link.springer.com]

  • Autoimmune Lymphoproliferative Syndrome

    CONCLUSION: FAS ligand deficiency should be screened in patients presenting with ALPS features but lacking the usual markers, including plasma soluble FAS ligand and an in[ncbi.nlm.nih.gov] Grupp , Targeting Notch signaling in autoimmune and lymphoproliferative disease , Blood , 10.1182/blood-2007-05-087353 , 111 , 2 , (705-714) , (2008) . Valerie I.[doi.org] Grupp , Targeting Notch signaling in autoimmune and lymphoproliferative disease , Blood , 10.1182/blood-2007-05-087353 , 111 , 2 , (705-714) , (2008) . Abdiaziz S.[doi.org]

  • Deficiency of Interleukin-36-Receptor Antagonist

    IL-1RL2 and its ligands contribute to the cytokine network in psoriasis. J Immunol. 2010; 185 (7):4354–4362. [ PubMed ] 16.[ncbi.nlm.nih.gov] 3/16" (6 mm x 5 mm) V-notched trowel, 5/16" x 5/16" (8 mm x 8 mm) V-notched trowel, or the DITRA trowel, which features a 11/64" x 11/64" (4.5 mm x 4.5 mm)square-notched design[schluter.com] Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med. 2007; 204 (11):2603–2614. [ PMC free article ] [ PubMed ] 15.[ncbi.nlm.nih.gov]

  • Hutchinson's Teeth

    T. pallidum attaches to host cell surfaces by a ligand-receptor type process. The microbes are only able to replicate when attached to mammalian cells.[cancertherapyadvisor.com] Basically Hutchinson teeth appear as notches on the biting surfaces of teeth. Babies with syphilis have smaller and spaced teeth along with notches on them.[healthgala.info] Hutchinson's teeth Notched incisors known as Hutchinson's teeth which are characteristic of congenital syphilis Editor-In-Chief: C.[wikidoc.org]

  • Autosomal Dominant Spondylocostal Dysostosis

    The most common form of the disease, Spondylocostal dysostosis designated as Type 1 develops as a result of mutations in the gene DLL3 (delta Notch ligand like canonical 3[ivami.com] […] extracellular domain; NEXT, Notch external truncation; NICD, Notch intracellular domain; SCD, spondylocostal dysostosis; T-ALL, T cell acute lymphatic leukemia.[jcb.rupress.org] 3 [KO: K06051 ] 28514 DLL1; delta like canonical Notch ligand 1 [KO: K06051 ] 54567 DLL4; delta like canonical Notch ligand 4 [KO: K06051 ] 182 JAG1; jagged 1 [KO: K06052[genome.jp]

Further symptoms