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1,223 Possible Causes for Notch, ligand

  • Skin Infection

    […] adhesion assay analysis, and time-lapse microscopy, we found the patient's T lymphocytes to express normal levels of β1 and β2 integrins but to be highly adhesive to integrin ligands[ncbi.nlm.nih.gov] The 21-year-old LSU product entered the night with just eight career points to his name but exploded for 16 points on 7 of 10 shooting to notch an obvious career high. — Forward[nesn.com] CD8( ) T-cell recruitment to skin is independent of CD4( ) T cells and interferon-γ, but requires the expression of E- and P-selectin ligands by CD8( ) T cells.[ncbi.nlm.nih.gov]

  • Mucolipidosis

    […] can be increased using synthetic ligands.[ncbi.nlm.nih.gov] We also demonstrate a role for the Notch repeat 1 in lysosomal hydrolase recognition, as missense mutations in conserved cysteine residues in this domain do not affect the[ncbi.nlm.nih.gov] We also found that the F465L mutation renders TRPML1 pH insensitive, while F408Δ impacts synthetic ligand binding.[ncbi.nlm.nih.gov]

  • Biliary Atresia

    Programmed death-1 (PD-1) and its two ligands, programmed death ligand-1 and programmed death ligand-2 (PD-L1 and PD-L2, respectively) play an important inhibitory role in[ncbi.nlm.nih.gov] Given the role of Notch signaling in normal biliary development, we hypothesize that activated Notch signaling promotes the formation of ductular reactions in BA.[ncbi.nlm.nih.gov] […] to poly(I:C) (a synthetic analog of viral dsRNA), a TLR3 ligand.[ncbi.nlm.nih.gov]

  • Leprosy

    […] compromising NK cell maturation, lysing of infected cells, and CD4 Th1 differentiation. 2) VDR alterations and TLR polymorphisms may affect expression of Notch Delta-like ligands[ncbi.nlm.nih.gov] These innate and adaptive immune response elements may be related to the Notch signaling pathway, which is involved in immune cell growth, differentiation, and proliferation[ncbi.nlm.nih.gov] APCs). 3) altered DLL expression by APCs could compromise CD4 T cell differentiation towards the Th1 and Th17 effector phenotypes; and finally 4) expression of Notch Jagged ligands[ncbi.nlm.nih.gov]

  • Echinococcus Granulosus

    Among these families, Hydrophobic Ligand Binding Proteins (HLBPs) deserve special consideration since they comprise intracellular and extracellular members, are able to bind[ncbi.nlm.nih.gov] Abstract This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto[ncbi.nlm.nih.gov] Its protein component belongs to the cestode-specific Hydrophobic Ligand Binding Protein family, which includes five 8-kDa isoforms encoded by a multigene family (EgAgB1-EgAgB5[ncbi.nlm.nih.gov]

  • Endometriosis

    KEYWORDS: Drug design; Endometriosis; Small-molecule ligand; microRNA-21[ncbi.nlm.nih.gov] KEYWORDS: Adult stem cells; Endometriosis; Endometrium; Notch; Numb[ncbi.nlm.nih.gov] Recently, CXCR7, a C-X-C motif containing GPCR, has been identified as a receptor for chemokine ligand CXCL12, one of the best characterized chemokines for cell trafficking[ncbi.nlm.nih.gov]

  • Doxorubicin

    Activation of Notch signaling significantly reversed the inhibitory effect of miR-760 on Dox-resistance and abrogated the effect of miR-760 on the PTEN/Akt signaling pathway[ncbi.nlm.nih.gov] OBJECTIVE: One of the ligands of PPAR-δ is erucic acid (EA), an edible omega-9 fatty acid consumed more by Asian populations and exists highly in Chinese womens milk.[ncbi.nlm.nih.gov] […] that regulates the ligand affinity.[ncbi.nlm.nih.gov]

  • Dysostosis

    […] vertebral column, but also provides a paradigm for understanding how other ligands of Notch cis-inhibit signalling.[ncbi.nlm.nih.gov] We conclude that the phenotypic abnormalities in EvC and Weyers syndrome result from tissue specific disruption of the response to Hh ligands.[ncbi.nlm.nih.gov] We previously showed that mutations in delta-like 3 (DLL3), a somitogenesis gene that encodes a ligand for the notch signaling pathway, cause AR SCD with a consistent pattern[ncbi.nlm.nih.gov]

  • Intestinal Adenoma

    Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps.[ncbi.nlm.nih.gov]

  • Influenza Virus

    KEYWORDS: STD-NMR spectroscopy; anti-viral drug discovery; influenza-virus hemagglutinin; ligand-protein interaction; transfected cells[ncbi.nlm.nih.gov] […] human DAECs was achieved using co-culture with feeder cells and supplementation with epidermal growth factor (EGF), Rho-associated protein kinase inhibitor Y27632, and the Notch[ncbi.nlm.nih.gov] KEYWORDS: STD-NMR spectroscopy; antiviral drug discovery.; influenza virus Hemagglutinin; ligand–protein interaction; transfected cells[ncbi.nlm.nih.gov]

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