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2,640 Possible Causes for ONCOGENE

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  • Familial Medullary Thyroid Carcinoma

    Inherited forms of MTC are related to mutations in the RET proto-oncogene.[] Since these mutations are oncogenic by themselves, somatic mutations in the same gene had been thought unnecessary.[] Abstract Familial medullary thyroid carcinoma (FMTC) is an autosomal dominant inherited disease, characterized by germ-line mutations in the RET proto-oncogene, mainly in[]

  • Medullary Thyroid Carcinoma

    Inherited mutations in the RET proto-oncogene, which encodes a receptor tyrosine kinase, predispose individuals to the multiple endocrine neoplasia type 2 (MEN 2) cancer syndromes[] Most cases of multiple endocrine neoplasia type 2B (MEN-2B) are attributable to a germline methionine to threonine mutation at codon 918 (M918T) of the RET proto-oncogene;[] BACKGROUND: Hereditary medullary thyroid carcinoma (HMTC) is thought to be associated with germline mutations of the RET proto-oncogene.[]

  • Multiple Endocrine Neoplasia Type 2A

    We could find two asymptomatic MEN2A gene carriers who had no symptoms or signs of MEN 2A by DNA analysis of the RET proto-oncogene.[] The phenotype of the family with this rare point mutation of the RET proto-oncogene is reported.[] The cosegregation of multiple endocrine neoplasia (MEN) type 2A with Hirschsprung's disease (HSCR), two diseases associated with mutation of the RET proto-oncogene, is infrequent[]

  • Multiple Endocrine Neoplasia Type 2B

    We report a case of multiple endocrine neoplasia type 2B (MEN 2B) with de novo RET proto-oncogene mutation.[] ) or the human non-mutated RET proto-oncogene (CALC-WT-RET) in the C-cells.[] MEN2B has been associated with a specific point mutation in the tyrosine kinase domain of the RET proto-oncogene (918RET mutation).[]

  • Oncogenic Osteomalacia

    To highlight the clinical presentation and management of a rare case of oncogenic osteomalacia due to an ethmoid sinus tumour.[] The aim was to determine whether a malignant neoplasm could cause oncogenic osteomalacia through excessive production and secretion of FGF23.[] New insight into the pathophysiology of oncogenic osteomalacia is also presented.[]

  • T-cell Acute Lymphoblastic Leukemia

    Many oncogenes and tumor suppressors in T-ALL are transcription factors that are required for normal hematopoiesis.[] Yet, retroviral insertional mutagenesis screens identify RUNX genes as collaborating oncogenes in MYC-driven leukemia mouse models.[] Abstract Somatic mutations within noncoding genomic regions that aberrantly activate oncogenes have remained poorly characterized.[]

  • Hereditary Renal Cell Carcinoma

    We find that the c-myc oncogene (8q24.1) has been translocated to the derivative 3 [der(3)].[] Accordingly, MET is considered a proto-oncogene. As the name of the disease suggests, carriers are prone to develop papillary RCC.[] 雑誌 Biochim Biophys Acta 1796:201-15 (2009) DOI: 10.1016/j.bbcan.2009.04.005 文献 PMID: 19233641 著者 Prensner JR, Chinnaiyan AM タイトル Oncogenic gene fusions in epithelial carcinomas[]

  • Costello Syndrome

    We go on to show that expression of oncogenic HRAS in normal fibroblasts can repress C4ST-1 expression, whereas interference with oncogenic HRAS signaling in Costello syndrome[] We identified four heterozygous de novo mutations of HRAS in 12 of 13 affected individuals, all of which were previously reported as somatic and oncogenic mutations in various[] Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA. Abstract Costello syndrome is a pediatric genetic disorder linked to oncogenic[]

  • Epidermodysplasia Verruciformis

    The first evidence for the oncogenic potential of human papillomaviruses (HPVs) was obtained through the study of epidermodysplasia verruciformis (EV).[] Human papillomavirus (HPV) types 5 and 8 are the most commonly isolated EDV-HPV subtypes as well as the most oncogenic subtypes, carrying the greatest risk for malignant transformation[] Through the observation of our patient and review of the literature, we hypothesized that the pathomechanisms, including the role of oncogenes and cytokines, are connected[]

  • Childhood Gastric Cancer

    With regards to genetic conditions contributing to the development of isolated gastric cancer, acquired mutations of the proto-oncogene HER2 are among the pathophysiological[]

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