Create issue ticket

573 Possible Causes for Orotate

  • Ornithine Transcarbamylase Deficiency

    BACKGROUND: Orotic acid (OA) is the key parameter in the detection of ornithine transcarbamylase deficiency (OTC-D).[] Five months after discharge, urinary uracil concentration remained elevated despite normalized orotic acid concentration.[] With higher residual enzyme activity, spf-J were found to have normal plasma ammonia and orotate.[]

  • Flumazenil

    Abnormally high levels of orotic acid were found in serum and urine, confirming the diagnosis of ornithine transcarbamylase deficiency.[]

  • Mycoplasma Penetrans

    Orotate-related metabolism is related to an ATP synthesis system called the arginine dihydrolase pathway (1).[] Mycoplasma penetrans has a set of genes that code for enzymes which are involved in orotate-related metabolism (1).[] Mycoplasma penetrans also has another pathway that converts carbamoyl-phosphate to UMP via orotate-related metabolism (1).[]

  • Coma

    Measurement of plasma ammonia concentration, followed by measurement of plasma amino acid and urine orotic acid levels allowed to diagnose the OTC deficit, lately confirmed[]

  • Hypertension

    BACKGROUND: To determine whether the effectiveness and safety of fixed-dose combinations (FDCs) of amlodipine orotate/valsartan (AML/VAL) 5/160 mg are noninferior to those[]

  • Calcium Deficiency

    Magnesium orotate is the most highly bioavailable magnesium supplement.[] I recommend calcium orotate for the best absorption and bioavailability.[] Types of Supplements Calcium carbonate Calcium citrate Calcium orotate Calcium comes in a variety of supplemental forms.[]

  • Homocystinuria

    […] procedure, which consists of urease treatment, stable isotope dilution and GC-MS, enables a simultaneous quantification of methionine, homocystine, cystine, methylmalonate, orotate[] Analysis with this procedure showed that a case of homocystinuria type I, who progressed into transient megaloblastic anemia, secondarily excreted an increased concentration of orotate[]

  • Temozolomide

    By Matthew Stenger Posted: 5/9/2018 11:02:18 AM Last Updated: 5/9/2018 11:02:18 AM The combination was well tolerated, with a carboxyamidotriazole orotate flat dose of 600[] Combinatorial treatment with carboxyamidotriazole- orotate and temozolomide in sc-implanted human LOX IMVI melanoma xenografts Abstract Background: Carboxyamidotriazole orotate[] No dose-limiting toxicities were observed, and the recommended carboxyamidotriazole orotate dose for phase II study was selected as 600 mg/d as a flat dose.[]

  • Streptozocin

    Nucleotide and RNA metabolism was studied in the renal cortex after infusion of radio-labeled orotate or adenine.[]

  • Attention Deficit Hyperactivity Disorder

    Repeated evaluations revealed hyperammonemia and orotic aciduria, and she was diagnosed as having an OTC deficiency.[]

Further symptoms