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2,160 Possible Causes for PERP,, TP53, apoptosis, effector, human, protein

Did you mean: PERP, TP53, apoptosis, effector, human, proteus

  • LIG4 Syndrome

    […] high level of apoptosis.[jneurosci.org] […] and CD62L within CD4 (top) and CD8 (bottom) splenic T cells from an R/R mouse and its / littermate control. ( Lower Right ) Distribution of naive (CD44 lo CD62L hi ) and effector[pnas.org] HRR-related Rad54-KO, NHEJR-related Lig4-KO, and wild-type TP53-KO MEF were also included to confirm the suppressing effect specificity of these inhibitors.[cancerindex.org] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[zfin.org] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Dynamin protein contain a variety of IKZF2 antibody conserved domains: a GTPase area for GTP hydrolysis; a pleckstrin homology (PH) area mediating lipid binding; a GTPase effector[perlierusa.com]

    Missing: PERP
  • T-cell Acute Lymphoblastic Leukemia

    Consistent with this, it was demonstrated that cotreatment of bortezomib and daunorubicin efficiently induced apoptosis in primary T‑ALL cells, and cell death was associated[ncbi.nlm.nih.gov] In order to identify putative downstream targets/effectors involved in the pro-oncogenic activity of Cn in T-cell acute lymphoblastic leukemia (T-ALL) we used tandem affinity[ncbi.nlm.nih.gov] ABL1 amplification 17p- (17p deletion) or TP53 9p- (9p deletion) or CDKN2A or p16 t(10;11)(p13;q14) - MLLT10/PICALM or AF10/PICALM t(10;11)(p13;q23) - MLLT10/MLL t(10;14)([mayomedicallaboratories.com] Plumbagin is a natural, plant derived compound, which exerts an anti-proliferative activity against many types of human cancer.[ncbi.nlm.nih.gov] * Neoplasm Proteins/biosynthesis Neoplasm Proteins/genetics Nuclear Proteins/antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* Protein[ncbi.nlm.nih.gov] Our results showed that in murine and pediatric T-ALL, loss of KLF4 leads to aberrant activation of MAP2K7 and of the downstream effectors JNK and ATF2.[ncbi.nlm.nih.gov]

    Missing: PERP
  • Influenza

    PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.[genome.jp] Effector cells were mixed with EL-4 target cells at the ratios indicated. Values show percent lysis.[doi.org] The rapid evolution of influenza A and B viruses contributes to annual influenza epidemics in humans.[ncbi.nlm.nih.gov] Like hemagglutinin and neuraminidase, the M2 protein is an integral membrane protein of the influenza A virus 4 , 5 .[doi.org] […] through the death-receptor and mitochondrial apoptosis pathways.[doi.org] The RNA-binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses. Virology . 1996 ; 223 : 41 – 50 .[doi.org]

    Missing: PERP TP53
  • Primary Effusion Lymphoma

    Sangivamycin induced the apoptosis of PEL cells by activating caspase-7 and -9.[ncbi.nlm.nih.gov] T cell immunity limits KSHV infection and disease, however the virus employs multiple mechanisms to inhibit efficient control by these effectors.[ncbi.nlm.nih.gov] […] lymphomas in people with HIV/AIDS Histotype BL DLBCL-CB DLBCL-IB PBL PEL Viral Infection EBV /- -/ /- /- KSHV - - - - Genetic abnormalities BCL2 - - 30% 20% - BCL6 100% 75% - - TP53[atlasgeneticsoncology.org] 8) in conjunction with human immunodeficiency virus (HIV) infection.[ncbi.nlm.nih.gov] The mRNA and protein levels of hTERT were examined by real time-PCR and Western blotting, respectively.[ncbi.nlm.nih.gov] […] of Solid Extracavitary Variant of Primary Effusion Lymphoma in an HIV-Positive Patient. ( 29619259 ) Hashmi H....Tse W. 2018 9 CK1I and IRF4 are essential and independent effectors[malacards.org]

    Missing: PERP
  • Ehrlichia Chaffeensis

    E. chaffeensis infection in a human monocyte cell line (THP1) significantly altered the transcriptional levels of 4.5% of host genes, including those coding for apoptosis[ncbi.nlm.nih.gov] The mechanisms involved are not fully defined, but appear to rely largely on a subset of tandem repeat proteins (TRP) effectors.[ncbi.nlm.nih.gov] Upon incubation with human monocytes, E. chaffeensis neither induced O(2)(-) generation by human monocytes, nor colocalized with nicotinamide adenine dinucleotide phosphate[ncbi.nlm.nih.gov] Additional E. chaffeensis surface proteins detected were OMP85, hypothetical protein ECH_0525 (here named Esp73), immunodominant surface protein gp47, and 11 other proteins[ncbi.nlm.nih.gov] Abstract Ehrlichia chaffeensis causes human monocytic ehrlichiosis (HME) that usually includes fever, myalgias, and pancytopenia and, in 80% to 90% of patients, elevations[ncbi.nlm.nih.gov] In this study, we investigated the effects of c-di-GMP signaling on E. chaffeensis infection of the human monocytic cell line THP-1.[ncbi.nlm.nih.gov]

    Missing: PERP TP53
  • Phenformin

    In addition, phenformin induced CCA cell apoptosis and autophagy.[ncbi.nlm.nih.gov] Treatment with both drugs was required to fully suppress mechanistic target of rapamycin signaling, a known effector of NF1 loss.[ncbi.nlm.nih.gov] MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53[ncbi.nlm.nih.gov] Abstract The effects of the oral hypoglycemic agent, phenformin, were studied on the binding of 125I-insulin to its receptors in IM-9 human cultured lymphocytes.[ncbi.nlm.nih.gov] Activation of the unfolded protein response (UPR) is associated with the disruption of endoplasmic reticulum (ER) homeostasis and has been implicated in the pathogenesis of[ncbi.nlm.nih.gov] Phenformin induced cell cycle change and apoptosis in breast cancer cells via the AMPK/mTOR/p70s6k and MAPK/ERK pathways.[ncbi.nlm.nih.gov]

  • Herpes Simplex Virus 1 Infection

    […] to HSV-1-dependent apoptosis.[ncbi.nlm.nih.gov] Intraperitoneal administration of anti-PDL-1 monoclonal antibody given one day prior to and three days after cutaneous HSV-1 infection, resulted in a marked increase in effector[ncbi.nlm.nih.gov] We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes simplex[ncbi.nlm.nih.gov] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[ncbi.nlm.nih.gov] […] cytoplasmic sensor molecules, such as NLRP3 and AIM2 or nuclear sensor IFI16, the adaptor protein ASC (apoptosis-associated speck-like protein containing CARD), and the effector[ncbi.nlm.nih.gov] Although the double-stranded RNA-dependent protein kinase (PKR) is activated during HSV infection, the gamma(1)34.5 protein inhibits the activity of PKR by mediating dephosphorylation[ncbi.nlm.nih.gov]

    Missing: PERP TP53
  • Adenovirus

    CONCLUSION: Loss of survivin expression enhanced paclitaxel-induced apoptosis in MCF-7 breast cancer cells in vitro.[ncbi.nlm.nih.gov] Pharmacological-and-rAAV-Gene-Therapy-Rescue-of-Visual-Functions-in-a-Blind-Mouse-Model-of-Leber-pmed.0020333.sv002.ogv 30秒、 320 240; 5.08メガバイト Synapsin and CamK2 positive neurons.png 1,180 955; 1.82メガバイト TEVA adenovirus.jpg 405 354; 19キロバイト メディアを再生する The-Rab5-Effector-Rabankyrin[commons.wikimedia.org] […] response factor) SYN2 synapsin II TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) TNIK TRAF2 and NCK interacting kinase TNNI3 troponin I type 3 (cardiac) TP53[amp.pharm.mssm.edu] […] complications Adenovirus Infections, Human/virology* Adenoviruses, Human/genetics* Adenoviruses, Human/physiology* Adolescent Adult Antigens, Viral, Tumor/genetics BK Virus[ncbi.nlm.nih.gov] KEYWORDS: 22K; 33K; 52K; BAdV-3; NLS; Protein- protein interaction[ncbi.nlm.nih.gov] .0020333.sv002.ogv 30 s, 320 240; 5,08 MB Synapsin and CamK2 positive neurons.png 1 180 955; 1,82 MB TEVA adenovirus.jpg 405 354; 19 KB Riproduci file multimediale The-Rab5-Effector-Rabankyrin[commons.wikimedia.org]

    Missing: PERP
  • Arsenic Trioxide

    Apoptosis-related protein levels were tested by Western blot.[ncbi.nlm.nih.gov] Increases in the activated forms of DNA damage signaling proteins, ATM and ATR, and their effector molecules, Chk2 and p53, were also observed.[ncbi.nlm.nih.gov] Toxicol Appl Pharmacol. 2005 Nov 1;208(3):277-84. [ PubMed:16239170 ] Kind Protein Organism Humans Pharmacological action Unknown General Function May be involved in p53/TP53[drugbank.ca] We determined the combinatory effects of DHA and ATO on cytotoxicity of human lung adenocarcinoma (A549) cells.[ncbi.nlm.nih.gov] Abstract Signal regulatory protein α (SIRPα) has been shown to operate as a negative regulator in cancer cell survival.[ncbi.nlm.nih.gov] The results further showed that the expression of transcription factor Nrf2 and its downstream antioxidant effectors, including hemeoxygenase-1, glutathione, and superoxide[ncbi.nlm.nih.gov]

    Missing: PERP
  • Quinacrine

    QN also significantly enhanced C1027-induced apoptosis in BJAB cells, and the inhibition of apoptosis was observed in BJAB cells transfected with Bcl-2 gene.[ncbi.nlm.nih.gov] […] non-resistant K562 cells could be because of the direct injury and the potentiating apoptotic effect of vincristine via activating the initiator caspase-9 and subsequently the effector[ncbi.nlm.nih.gov] EXPERIMENTAL DESIGN: TP53 genotype, mRNA and protein expression, TP53-induced p21 expression, and TP53 DNA-binding and reporter gene function were determined in a panel of[ncbi.nlm.nih.gov] Despite its development in the 1970s, the cellular and molecular events induced by quinacrine in the human fallopian tube have not been described.[ncbi.nlm.nih.gov] The drug was suggested to "covalently" modify the prion protein via an acridinyl exchange reaction.[ncbi.nlm.nih.gov] This manuscript reports physicochemical behavior of an antimalarial drug Quinacrine 2HCl (QUN) drug as well as its interaction with surfactant and Human Serum Albumin (HSA[ncbi.nlm.nih.gov]

    Missing: PERP