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57 Possible Causes for PGRP

  • Wolbachia

    Tissue- and ligand-specific sensing of Gram-negative infection in Drosophila by PGRP-LC isoforms and PGRP-LE. J. Biol.[frontiersin.org] PGRP-LC and PGRP-LE have essential yet distinct functions in the Drosophila immune response to monomeric DAP-type peptidoglycan. Nat.[frontiersin.org] In Drosophila , for example, one type of PGRP (PGRP-LE) acts as an intracellular receptor for DAP-type PG and thus as an intracellular sensor of Gram-negative bacteria ( Kaneko[frontiersin.org]

  • FADD-Related Immunodeficiency

    […] psh Dif IkkB Protein Toll spirit Ikky PolyUb spheroide PGRP-SD PGRP-LB Tab2 Myd88 sphinx1 STAT sphinx2 imd PolyUb TRAF2 grass Socs SPE PGRP-LC Cactus PolyUb Tak1 PGRP-SA[wikipathways.org] STAT Pathway IMD Pathway DAP-Type PGN Virus K-Type PGN Toll Pathway Upregulation of Immune Genes Yeast Phosphorylation Promote Ubiquitin Binding Fungi Effector Genes nec PGRP-SC[wikipathways.org] […] dome spz GNBP2 PIAS Protein Tube PGRP-LE GNBP1 Relish JNK Fadd spz2 Dredd PolyUb Protein pellino Pelle PolyUb Dorsal dome GNBP3 JAK JAK P P P P CLIP-SP STAT STAT STAT STAT[wikipathways.org]

  • Gram Negative Bacterial Infection

    […] and PGRP-LE for the IMD pathway and PGRP-SA/GNBP1/PGRP-SD for the Toll pathway.[sdbonline.org] PGRP-LE, a secreted member of the PGRP family, is also involved in sensing Gram-negative bacteria (Kaneko, 2006).[sdbonline.org] Indeed, mutations in GNBP1 (osiris) or PGRP-SA (semmelweiss (PGRP-SA mutant)) reduced significantly PO activity after M. luteus infection.[sdbonline.org]

  • Autosomal Recessive Spastic Paraplegia Type 18

    The minimum PGN fragment hydrolyzed by PGRP-L is MurNAc-tripeptide [18] .[wikigenes.org] Therefore, mammalian PGRP binds to PGN and Gram-positive bacteria with nanomolar affinity, is expressed in neutrophils , and inhibits growth of bacteria [15] .[wikigenes.org] We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the[wikigenes.org]

  • Pure Hereditary Spastic Paraplegia

    The minimum PGN fragment hydrolyzed by PGRP-L is MurNAc-tripeptide [18] .[wikigenes.org] Therefore, mammalian PGRP binds to PGN and Gram-positive bacteria with nanomolar affinity, is expressed in neutrophils , and inhibits growth of bacteria [15] .[wikigenes.org] We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the[wikigenes.org]

  • Autosomal Recessive Spastic Paraplegia Type 21

    The minimum PGN fragment hydrolyzed by PGRP-L is MurNAc-tripeptide [18] .[wikigenes.org] Therefore, mammalian PGRP binds to PGN and Gram-positive bacteria with nanomolar affinity, is expressed in neutrophils , and inhibits growth of bacteria [15] .[wikigenes.org] We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the[wikigenes.org]

  • Autosomal Recessive Spastic Paraplegia Type 25

    The minimum PGN fragment hydrolyzed by PGRP-L is MurNAc-tripeptide [18] .[wikigenes.org] Therefore, mammalian PGRP binds to PGN and Gram-positive bacteria with nanomolar affinity, is expressed in neutrophils , and inhibits growth of bacteria [15] .[wikigenes.org] We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the[wikigenes.org]

  • Autosomal Recessive Spastic Paraplegia Type 23

    The minimum PGN fragment hydrolyzed by PGRP-L is MurNAc-tripeptide [18] .[wikigenes.org] Therefore, mammalian PGRP binds to PGN and Gram-positive bacteria with nanomolar affinity, is expressed in neutrophils , and inhibits growth of bacteria [15] .[wikigenes.org] We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the[wikigenes.org]

  • Autosomal Recessive Spastic Paraplegia Type 24

    The minimum PGN fragment hydrolyzed by PGRP-L is MurNAc-tripeptide [18] .[wikigenes.org] Therefore, mammalian PGRP binds to PGN and Gram-positive bacteria with nanomolar affinity, is expressed in neutrophils , and inhibits growth of bacteria [15] .[wikigenes.org] We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the[wikigenes.org]

  • Autosomal Recessive Spastic Paraplegia Type 7

    The minimum PGN fragment hydrolyzed by PGRP-L is MurNAc-tripeptide [18] .[wikigenes.org] Therefore, mammalian PGRP binds to PGN and Gram-positive bacteria with nanomolar affinity, is expressed in neutrophils , and inhibits growth of bacteria [15] .[wikigenes.org] We determined the crystal structure, at 2.30-A resolution, of the C-terminal PGN-binding domain of human PGRP-Ialpha in complex with a muramyl tripeptide representing the[wikigenes.org]

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