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37 Possible Causes for PIK3R3, human, protein

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  • Lymphatic Malformation

    One is an inherited, premature stop codon in the PI3K regulatory subunit PIK3R3.[] Formation of inflammation-related tertiary lymphoid organs promotes human lymphatic malformation (LM) development.[] […] endothelial proteins (podoplanin, VEGFR-3).[]

  • Squamous Cell Carcinoma of the Lung

    Additionally, obvious correlations were found between multiple pathways by sharing cross-talk genes (EGFR, PRKX, PDGFB, PIK3R3, SLK, IGF1, CDC42 and PRKCA).[] The IκB kinase inhibitor of κB kinase epsilon (IKBKE) is overexpressed in several human cancers.[] Argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) and Ki-67 antigen were analyzed in 118 samples of squamous cell carcinoma of the lungs.[]

  • Isoproterenol

    Gene Name PIK3R3 Uniprot ID Q92569 Uniprot Name Phosphatidylinositol 3-kinase regulatory subunit gamma Molecular Weight 54448.0 Da References Slomiany BL, Slomiany A: Salivary[] We examined the expression of alpha1- and beta-ARs in human HCC cell line HepG2 and MHCC97H cells in comparison with that in human normal hepatic cell line HL-7702 cells ([] Therefore, we investigated the protein expression profile and signaling transduction in HL-l cardiomyocyte cells treated with ET-1 and ISO.[]

  • Idiopathic Interstitial Pneumonia

    1.40 7986446 ALDH1A3 3.1E-05 1.49 0.0020 1.37 8105040 OSMR 0.00012 1.33 3.00E-05 1.35 8043995 IL1R1 3.4E-05 1.34 3.8E-05 1.35 7922610 ABL2 0.00034 1.39 3.8E-05 1.33 7915787 PIK3R3[] We studied the roles of mast cell chymase in the fibritic processes of human idiopathic interstitial pneumonias.[] , surfactant protein-D and Krebs von den Lungen-6 levels were measured in the serum.[]

  • Chronic Myeloid Leukemia

    [EC: ] 5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO: K02649 ] 5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO: K02649 ] 8503 PIK3R3[] The mRNA/protein of EphB4 was overexpressed in the DAS-resistant A2-E2 in comparison with the A1-E1 human cell lines.[] […] and Akirin-2 or β-catenin proteins.[]

  • Renal Metastasis

    , RAF1 miR-19b 326 PIK3CA, HIF1A, KRAS, PAK6, RAP1B, RAP1A, PIK3R3, RAF1 miR-20a 293 HIF1A, EGLN3, EPAS1, VEGFA, CRK, MAPK1, PAK7, EGLN1 miR-21 67 PIK3R1 miR-26a 206 HGF,[] Metastatic Human Renal Cell Carcinoma Cell Line Collection Cell Line Metastatic Site Growth in Nude Mice Growth in Soft Agar SK-RC-9 Brain No Yes SK-RC-13 * Brain Yes No SK-RC[] The protein kinase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis and receptor tyrosine kinase crosstalk in cancer.[]

  • Familial Congenital Mirror Movements 2

    FANCC; FANCG Pathways in cancer GNB3; FGF18; FZD9; SMO; TCEB2; PRKACB; RASSF5; GNGT2; PTK2; RALGDS Pancreatic cancer PIK3R2; NFKB1; ERBB2; AKT1; IKBKB; CASP9; RELA; RB1; PIK3R3[] Human RAD51 shows predominant expression in testis, ovary, and lymphoid tissue.[] Multiple protein interactions have been demonstrated for the mammalian Rad51 protein.[]

  • Malignant Migrating Partial Seizures of Infancy

    TMS, TS 781 CACNA2D1, CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3, MHS3 783 CACNB2, CACNLB2, CAVB2, MYSB 815 CAMK2A, CAMKA 8379 MAD1L1, MAD1, PIG9, TP53I9, TXBP181 8503 PIK3R3[] CAT#: RC210197 PLCB1 (Myc-DDK-tagged)-Human phospholipase C, beta 1 (phosphoinositide-specific) (PLCB1), transcript variant 1 Need custom modification / cloning service?[] In addition to regulating ion flux, KCNT1 has a non-conducting function, as its C terminus interacts with cytoplasmic proteins involved in developmental signaling pathways[]

  • Idiopathic Familial Pulmonary Arterial Hypertension

    LDLRAP1A; CAV1; CHMP6; HGS; CHMP1B; RAB22A; SMAP1 Focal adhesion ELK1; VCLA; VEGFB; ITGB3B; VEGFAA; CAPN2A; PAK4; ACTN3B; RAP1AB; PIK3R5 Bacterial invasion of epithelial cells PIK3R3[] Metabolism, organism-specific biosystem (from REACTOME) Metabolism, organism-specific biosystem Metabolic processes in human cells generate energy through the oxidation of[] Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation.[]

  • Hypoinsulinemic Hypoglycemia and Body Hemihypertrophy

    PIK3R3 - Phosphoinositide-3-kinase, regulatory subunit 3 (gamma); Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase[] Information by UniProt Functional Studies - Recombinant human AKT2 protein (ab60322) Sample Kinase Activity Plot.[] Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11.[]