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279 Possible Causes for PR3

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  • Otitis Media

    Abstract Otitis media (OM) is well known as a common feature of proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA)-related Wegener granulomatosis, but is a very rare[ncbi.nlm.nih.gov]

  • Meningitis

    Proteinase 3-ANCA (PR3-ANCA) positive otitis media causes granulomatous formation or middle ear effusion in the middle ear, on the other hand myeloperoxidase-ANCA (MPO-ANCA[science.gov] […] progressive hearing loss; (2) predominantly female (73%) and older (median age: 68 years); (3) predominantly myeloperoxidase (MPO)-ANCA-positive (60%), followed by proteinase 3 (PR3[science.gov]

  • Tuberculosis

    An enzyme-linked immunosorbent assay was performed for anti-myeloperoxidase (MPO) and anti-proteinase 3 (PR3) detection.[ncbi.nlm.nih.gov] 103) of patients, whereas cytoplasmic ANCA (c-ANCA) was not detected; 1.9% (2/103) of patients with tuberculosis was positive for anti-MPO antibodies, and none had anti-PR3[ncbi.nlm.nih.gov]

  • Granulomatosis with Polyangiitis

    No significant change in in vitro PR3-ANCA levels occurred prior to relapse, compared to non-relapse patients.[ncbi.nlm.nih.gov] KEYWORDS: ANCA vasculitis; Anti-PR3 antibodies; Granulomatosis with polyangiitis; Mixed connective tissue disease; U1RNP antibodies[ncbi.nlm.nih.gov] Among the patients, 376 were positive for MPO-ANCA and 62 for PR3-ANCA.[ncbi.nlm.nih.gov]

  • Immune Complex–Mediated Small Vessel Vasculitis

    ELISA or EIA assay tests identify enzyme targets within the neutrophils, such as PR3-ANCA or MPO-ANCA.[the-rheumatologist.org] ANCA antibodies have two major antigen specificities in patients with vasculitis: anti-myeloperoxidase (MPO)-ANCA and anti-proteinase 3 (PR3)-ANCA.[propath.com] In the mouse, anti-Pr3 antibodies elicited by immunization of Pr3/elastase-deficient mice with recombinant murine Pr3 did not appear to be pathogenic by themselves but did[karger.com]

  • Renal Vasculitis

    The advantageous effect of PE was related to the presence of anti-proteinase3 (PR3)-antibodies and also evident among patients with plasma creatinine less than 500 μM.[ncbi.nlm.nih.gov] Furthermore, the ratio of serum MPO to PR3-ANCA among Japanese with PRV was much higher than that found among European and US patients.[ncbi.nlm.nih.gov] METHODS: Our study included 5 patients, 4 patients with myeloperoxidase (MPO)-ANCA-associated renal vasculitis and 1 patient with proteinase 3 (PR3)-ANCA-associated renal[ncbi.nlm.nih.gov]

  • Rapidly Progressive Glomerulonephritis

    The patient was positive for anti-proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) and rheumatoid factor (RF) with hypocomplementemia.[ncbi.nlm.nih.gov] The dot-blot revealed a sensitivity of 92-95% for PR3-ANCA and 80-86% for MPO-ANCA. The specificity of the dot-blot for PR3- and MPO-ANCA was 100%.[ncbi.nlm.nih.gov] Agreement with classical enzyme-linked immunosorbent assay and IIF was very good for anti-GBM autoAb, MPO-ANCA, PR3-ANCA, and ANCA, respectively.[ncbi.nlm.nih.gov]

  • Microscopic Polyangiitis

    Analysis of follow-up samples in this cohort showed that the presence of IgM PR3-ANCA was transient, but could recur.[ncbi.nlm.nih.gov] The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications.[ncbi.nlm.nih.gov] ANCA in MPA are predominantly directed against myeloperoxidase (MPO-ANCA) but may, in a minority of patients, be directed against proteinase 3 (PR3-ANCA).[ncbi.nlm.nih.gov]

  • Systemic Vasculitis

    Antimyeloperoxidase antibodies (MPO)-ANCA and antiproteinase 3 antibodies (PR3)-ANCA were strongly positive.[ncbi.nlm.nih.gov] All sera positive for C-ANCA by immunofluorescence test were PR3-ANCA positive.[doi.org] ANCAs directed against either myeloperoxidase (MPO) or proteinase 3 (PR3) can activate cytokine-primed neutrophils by binding cell surface–expressed MPO or PR3, with the concurrent[bloodjournal.org]

  • Pauci-Immune Glomerulonephritis

    Patients with active GPA usually have PR3-ANCA.[abdominalkey.com] ANCA MPO was positive in all six patients, while ANCA PR3 was negative in all. All patients received corticosteroids and 70% received cyclophosphamide.[ncbi.nlm.nih.gov] Of 11 patients where enzyme-linked immunosorbent assays (ELISAs) for MPO-ANCA and PR3-ANCA were performed [Table 2] , [Table 3] , [Table 4] , PR3-ANCA was positive in five[ijpmonline.org]

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