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28 Possible Causes for PRAD1

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  • Parathyroid Adenoma

    The cyclin D1 (PRAD1) oncogene is rearranged with the PTH gene and is transcriptionally activated in a subset of parathyroid adenomas.[ncbi.nlm.nih.gov] Abstract The cyclin D1 (PRAD1) oncogene is rearranged with the PTH gene and is transcriptionally activated in a subset of parathyroid adenomas.[doi.org] […] significant proportion of primary and secondary parathyroid hyperplasias. 21 , 22 One of the molecular abnormalities described in these tumors involves the cyclin D1 ( CCND1 / PRAD1[nature.com]

  • Familial Isolated Hyperparathyroidism

    PRAD1 was not overexpressed in the parathyroid tumors in this family.[ncbi.nlm.nih.gov] Woodard GE, Lin L, Zhang JH, et al, 2005 Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression.[hormones.gr] May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.[genecards.org]

  • Hyperparathyroidism-Jaw Tumor Syndrome

    Arnold A, Motokura T, Bloom T, Rosenberg C, Bale A, Kronenberg H, Ruderman J, Brown M, Kim HG: PRAD1 (cyclin D1): A parathyroid neoplasia gene on 11q13.[karger.com] […] malignancy have been identified and studied ( J Bone Miner Res 2008;23:1869 ) p53 Breast carcinoma susceptibility ( BRCA2 ) Cyclin D1 / parathyroid adenomatosis gene 1 ( PRAD1[pathologyoutlines.com] Hsi ED, Zukerberg LR, Yang WI, Arnold A: Cyclin D1/PRAD1 expression in parathyroid adenomas: An immunohistochemical study. J Clin Endocrinol Metab 1996;81:1736–1739.[karger.com]

  • Parathyroid Carcinoma

    […] malignancy have been identified and studied ( J Bone Miner Res 2008;23:1869 ) p53 Breast carcinoma susceptibility ( BRCA2 ) Cyclin D1 / parathyroid adenomatosis gene 1 ( PRAD1[pathologyoutlines.com] Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene . 2005 Feb 10. 24(7):1272-6. [Medline] .[emedicine.medscape.com]

  • Lymphoproliferative Disorder

    On the other hand, the molecular basis of some of these diseases (eg, the overexpression of the Prad1/CCND1 gene in mantle-cell lymphomas, the relationship between bcl-2 and[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    […] caution required for diagnosis, Blood 2005;106:4315 , Blood 2006;108:1109 ) Molecular / cytogenetics description t(11;14)(q13;q32): fusion of cyclin D1 (also called BCL1, PRAD1[pathologyoutlines.com] Seto M, Yamamoto K, Iida S et al. (1992) Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation.[els.net] PMID 8499640 Overexpression of PRAD1/cyclin D1 in plasma cell leukemia with t(11;14)(q13;q32).[atlasgeneticsoncology.org]

  • Primary Parathyroid Hyperplasia

    cyclin D1 (parathyroid adenoma 1) protein: inversion of gene on #11 puts PRAD1 next to 5'-PTH gene regulatory sequences which are constitutively active; seen in 10% of[pathologyoutlines.com] World J Surg 20 : 744 – 750, 1996 Tominaga Y, Tsuzuki T, Uchida K, Haba T, Otsuka S, Ichimori T, Yamada K, Numano M, Tanaka Y, Takagi H: Expression of PRAD1/cyclin D1, retinoblastoma[cjasn.asnjournals.org] […] significant proportion of primary and secondary parathyroid hyperplasias. 21 , 22 One of the molecular abnormalities described in these tumors involves the cyclin D1 ( CCND1 / PRAD1[nature.com]

  • Prolymphocytic Leukemia

    C-MYC and BCL-1/PRAD1 gene expression were also investigated.[ncbi.nlm.nih.gov] Detectable but weak BCL-1/PRAD1 RNA was present in both patients, whereas C-MYC RNA expression was clearly present only in case 1.[ncbi.nlm.nih.gov]

  • Primary Hyperparathyroidism

    cyclin D1 (parathyroid adenoma 1) protein: inversion of gene on #11 puts PRAD1 next to 5'-PTH gene regulatory sequences which are constitutively active; seen in 10% of[pathologyoutlines.com] Arnold Cyclin D1/PRAD1 expression in parathyroid adenomas [14.] F.R. Bringhurst, M.B. Demay, H.M.[analesdepediatria.org] These genes include MEN1, calcium-sensing receptor (CASR), HRPT2, RET (familial forms), and PRAD1/cyclin1 (sporadic tumors) 1 , 5 .[f1000research.com]

  • Osteitis Fibrosa Cystica

    Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene . Feb 10 2005;24(7):1272-6. [Medline] .[web.archive.org] Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression. Oncogene . 2005 Feb 10. 24(7):1272-6. [Medline] .[emedicine.medscape.com]

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