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281 Possible Causes for Peroxynitrites

  • Sinusitis

    Giovanna De Simone, Alessandra di Masi, Fabio Polticelli and Paolo Ascenzi , Human nitrobindin: the first example of an all‐β‐barrel ferric heme‐protein that catalyzes peroxynitrite[doi.org]

  • Borderline Leprosy

    CONCLUSIONS: Our results suggest that NO and peroxynitrite could be involved in the nerve damage following borderline leprosy.[ncbi.nlm.nih.gov] […] product of peroxynitrite, nitrotyrosine (NT).[ncbi.nlm.nih.gov] Peroxynitrite also mediated tyrosine nitration of albumin associated with the surface of Mtb.[diva-portal.org]

  • Tetrahydrobiopterin Deficiency

    […] certain neurotransmitters in the brain, which affects the function of the central nervous system (CNS), and dysregulation of the nitric oxide cycle leads to a buildup of peroxynitrite[en.wikipedia.org] So as Pall states the peroxynitrite/BH4 ratio seems to be an issue or said in another way the BH2/BH4 ratio. BH2 is recycled to BH4 by DHFR and DHPR.[forums.phoenixrising.me] And this may cause an increased uncoupling of NO-Synthase which so leads to an increase in peroxynitrite generation which causes quite rapidly weakness and getting worse.[forums.phoenixrising.me]

  • AIDS Dementia Complex

    One mechanism of oxidative damage is mediated by peroxynitrite, a neurotoxic reaction product of superoxide anion and nitric oxide.[ncbi.nlm.nih.gov] Finally, immunohistochemical staining for nitrotyrosine, a footprint for peroxynitrite, was performed to investigate whether peroxynitrite was present in the brains of demented[jimmunol.org] Expression of two cytokines and two key enzymes that are indicative of the presence of reactive oxygen intermediates and peroxynitrite was investigated in brain tissue of[ncbi.nlm.nih.gov]

  • Nitroprusside

    Collectively, peroxynitrite from the reaction between NO and O2•- elicited from SNP dominates the SNP-induced apoptosis of HepG2 cells, in which both iron ions and H2O2 are[ncbi.nlm.nih.gov] […] and can be reversed by peroxynitrite scavenger uric acid.[ncbi.nlm.nih.gov] Results showed that both UDCA and YS effectively attenuated the production of total reactive oxygen species (ROS), peroxynitrite (ONOO(-)) and nitric oxide (NO), and markedly[ncbi.nlm.nih.gov]

  • Coxsackievirus Infection

    Abstract Although peroxynitrite is harmful to the host, the beneficial effects of peroxynitrite are less well understood.[ncbi.nlm.nih.gov] Guanidinoethyl disulfide, a scavenger of peroxynitrite, blocks peroxynitrite inhibition of viral replication in vitro and permits an increase in viral replication in vivo.[ncbi.nlm.nih.gov] We explored the role of peroxynitrite in the host immune response to Coxsackievirus infection.[ncbi.nlm.nih.gov]

  • Amebic Liver Abscess

    Nevertheless, recent evidence downplays these mechanisms in abscess formation and emphasizes the importance of peroxynitrite (ONOO(-)).[ncbi.nlm.nih.gov] Another powerful oxidant is peroxynitrite, formed by the reaction of •NO and O2• .[commons.wikimedia.org]

  • Isolated Succinate-CoQ Reductase Deficiency

    […] and that Complex I is selectively sensitive to peroxynitrite.[biochemj.org] In addition, peroxynitrite mimicked the effect of NO, including tyrosine nitration of some Complex I proteins.[biochemj.org] NO induced the mitochondrial production of superoxide anions, hydrogen peroxide and peroxynitrite, the latter shown by nitration of mitochondrial proteins.[biochemj.org]

  • Rhinocerebral Mucormycosis

    Nitrotyrosine is the stable product of the nitration of tyrosine residues by peroxynitrite.[ncbi.nlm.nih.gov] Possible mechanisms of peroxynitrite's microbicidal effects and reasons for a deficiency in diabetics are discussed.[ncbi.nlm.nih.gov] Peroxynitrite is a potent oxidant produced by the combination of superoxide and nitric oxide during the respiratory burst. RESULTS: Four specimens were analyzed.[ncbi.nlm.nih.gov]

  • Platelet Glycoprotein IV Deficiency

    Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. ‏[books.google.com]

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