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6,911 Possible Causes for Platelet, Platelet, [interpretation], aggregation, IN, plasma, POOR

  • Clopidogrel

    […] binds irreversibly to the platelet P2Y 12 receptor.[content.onlinejacc.org] INTERPRETATION: The CYP2C19*2 genetic variant is a major determinant of prognosis in young patients who are receiving clopidogrel treatment after myocardial infarction.[ncbi.nlm.nih.gov] Pharmacometabolomics analysis of plasma revealed new insights on the implicated metabolic pathways and the predisposing factors of clopidogrel HTPR.[ncbi.nlm.nih.gov] "poor metabolizers") and therefore may not receive the full benefits of the drug.[web.archive.org] INTERPRETATION: Adding aspirin to clopidogrel in high-risk patients with recent ischaemic stroke or transient ischaemic attack is associated with a non-significant difference[ncbi.nlm.nih.gov] INTERPRETATION: People with the CYP3A5 non-expressor genotype are vulnerable to drug interactions between clopidogrel and CYP3A inhibitors.[ncbi.nlm.nih.gov]

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  • Thrombotic Thrombocytopenic Purpura

    BACKGROUND: Platelet microparticles (PMPs) have a procoagulant activity about 50-100 times greater than active platelets due to high expression of negatively charged phospholipids[ncbi.nlm.nih.gov] The peripheral blood smear was later interpreted by the hematopathologist to be inconsistent with TTP, and further workup led to a diagnosis of severe vitamin B12 deficiency[ncbi.nlm.nih.gov] When exposed to high shear stress in the microcirculation, VWF and platelets are prone to form aggregates.[ncbi.nlm.nih.gov] plasma.[doi.org] TTP is a rare complication of pregnancy with a poor prognosis and high fetal mortality, especially when it occurs during the first trimester.[ncbi.nlm.nih.gov] Abstract Atypical, non-diarrhoea associated haemolytic uraemic syndrome (D HUS) is a heterogeneous disorder with a generally poor outcome, although this view has now been[adc.bmj.com]

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  • Von Willebrand Disease

    A vaginal delivery was desired and plans were made for induction of labour at 38 weeks of gestation with platelet cover in view of the progressive fall of the platelet count[ncbi.nlm.nih.gov] Their diagnosis requires laboratory testing, with this potentially compromised by preanalytical events, including poor sample quality.[ncbi.nlm.nih.gov] Although laboratories usually provided correct interpretative responses, diagnostic errors occurred in a substantial number of cases.[ncbi.nlm.nih.gov] We assessed BS, VWF antigen and activity (minimum of 3 measurements), FVIII, PFA-100 , and platelet aggregation via Multiplate .[ncbi.nlm.nih.gov] The poor prediction of bleeding by conventional laboratory monitoring in VWD-3 patients might be related to insufficient restoration of platelet-dependent thrombus formation[ncbi.nlm.nih.gov] VWF expression in platelets and plasma was assessed via immunoblotting.[ncbi.nlm.nih.gov]

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  • Acquired Thrombotic Thrombocytopenic Purpura

    Maximal increase of platelet adhesion was observed under 2,050 s(-1) .[ncbi.nlm.nih.gov] INTERPRETATION AND CONCLUSIONS: Splenectomy, by eliminating a source of pathogenic autoantibody production, can be a successful treatment for patients with relapsing or plasma-refractory[ncbi.nlm.nih.gov] As a consequence, size regulation of VWF is impaired and the persistence of ultra-large VWF (ULVWF) multimers facilitates microvascular platelet aggregation causing microangiopathic[ncbi.nlm.nih.gov] RESULTS: Of 52 aTTP patients, 20 were good responders and 32 were poor responders.[ncbi.nlm.nih.gov] FINDINGS: We enrolled 973 patients with childhood-onset thrombotic microangiopathy, of whom 74 had a severe ADAMTS13 deficiency (activity INTERPRETATION: Our study shows that[ncbi.nlm.nih.gov] Abstract BACKGROUND: Acquired thrombotic thrombocytopenic purpura (TTP) is caused by aggregation of platelets on ultralarge von Willebrand factor multimers.[ncbi.nlm.nih.gov]

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  • Atypical Hemolytic Uremic Syndrome

    […] of platelets with purified CFH.[ncbi.nlm.nih.gov] Provides information to assist in interpretation of the test results An interpretive report will be included.[mayomedicallaboratories.com] After 22 sessions of plasma exchange, her lactate dehydrogenase levels started to climb.[ncbi.nlm.nih.gov] The other form, atypical HUS (aHUS), accounts for 10% of cases and has a poor prognosis. Genetic complement abnormalities have been found in aHUS.[ncbi.nlm.nih.gov] Combining patient serum/plasma with normal washed platelets led to C3 and C9 deposition, CD40L and CD62P expression, aggregate formation, and generation of tissue factor-expressing[ncbi.nlm.nih.gov] (7%-14% maximum aggregation; tracings c, d) after 14 minutes.[doi.org]

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  • Hemolytic Uremic Syndrome

    The effect of platelet transfusion in 44 patients who received platelet transfusions vs 206 control patients was investigated.[ncbi.nlm.nih.gov] Thirty-four children were included from which 11 with a complicated disease course/poor outcome.[ncbi.nlm.nih.gov] Provides information to assist in interpretation of the test results An interpretive report will be included.[mayomedicallaboratories.com] Abnormalities of anti–platelet-aggregating agents (eg, prostaglandin I 2 [PGI 2 ]), platelet-aggregating agents (thromboxane A 2 [TXA 2 ]) and von Willebrand factor (vWF)[emedicine.medscape.com] Compared to patients in remission and normal control subjects, patients with acute disease had significantly lower plasma CFH levels and significantly higher plasma complement[ncbi.nlm.nih.gov] Outcomes were variable and difficult to interpret in light of the absence of high-quality studies but seemed to point towards potential efficacy of eculizumab if administered[ncbi.nlm.nih.gov]

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  • Von Willebrand Disease Type 2B

    This phenomenon induces the clearance of both large multimers and platelets, usually resulting in thrombocytopenia with slightly increased platelet size.[ncbi.nlm.nih.gov] Negative Interpretation Provides information to assist in interpretation of the test results Interpretive report will include specimen information, assay information, background[mayomedicallaboratories.com] In vivo expression resulted in thrombocytopenia and circulating aggregates, both of which were more pronounced for mVWF/V1316M.[ncbi.nlm.nih.gov] With regard to TTP, a 2-fold (P .001) increase in activated VWF levels was found in plasma of patients with acquired TTP, whereas an 8-fold increase (P .003) was found in[ncbi.nlm.nih.gov] The study highlights the diagnostic limitations due to unavailability/poor application of RIPA and related tests in some centres and proposes genetic analysis as a suitable[th.schattauer.de] […] spontaneous binding and clearance of both vWF and platelets. 3,4 This feature allows type 2B, unlike most other vWD variants, to be exacerbated by pregnancy and to exhibit a poor[anesthesiology.pubs.asahq.org]

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  • Bernard-Soulier Syndrome

    Diagnosis can be confirmed by platelet aggregation studies and flow cytometry.[ncbi.nlm.nih.gov] Additional tests might include gene sequencing to identify the causative mutation and family studies Data Interpretation Click HERE to go to the Data Interpretation Exercises[practical-haemostasis.com] Thrombin-induced aggregation was normal in both parents.[ncbi.nlm.nih.gov] The agglutination of normal washed platelets was abolished by incubation in patient plasma.[ncbi.nlm.nih.gov] **mutations detected by Savoia et al . 5 In addition to these abnormalities, BSS platelets show additional functional defects including increased membrane deformability, poor[doi.org] This interpretation of the data has since been challenged by Zieger et al, 132 who also cloned a cDNA containing the GP Ibβ sequence.[bloodjournal.org]

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  • Acquired Von Willebrand Syndrome

    Platelet dysfunction and acquired von Willebrand syndrome (AVWS) may contribute to bleeding tendencies.[ncbi.nlm.nih.gov] Additional information regarding the use and interpretation of this test may be obtained by calling Quest Diagnostics genetic counselors at 1-866-GENE-INFO (1-866-436-3463[questdiagnostics.com] The antibodies directed against FVIIIRAg was demonstrated by the inhibitory effect of a platelet eluate on Ristocetin-induced aggregation of normal platelets.[ncbi.nlm.nih.gov] A prompt response to intravenous immunoglobulins (IVIG), but not to VWF/FVIII, was consistent with accelerated immunologic clearance of plasma VWF.[ncbi.nlm.nih.gov] […] vWF), with botrocetin (which detects high and low molecular weight vWF), and with platelet-aggregating factor (which detects high molecular weight vWF) provided a means of[ncbi.nlm.nih.gov] The coagulation data showed no improvement, possibly because the lymphoma showed a poor response to the treatment. AVWS rarely causes bleeding in solid organs.[ncbi.nlm.nih.gov]

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  • Thrombocytopathy

    This thrombocytopathy is discussed as a new variety of primary platelet disorder.[ncbi.nlm.nih.gov] The resulting hypercoagulable state followed by hyperfibrinolysis has been interpreted as a chronic low degree of disseminated intravascular coagulation [ 115 ].[aneskey.com] Biochemical Mechanisms of the System Regulating the Aggregate State of Blood EVOLUTION OF THEORY ON THE SYSTEM RESPONSIBLE FOR REGULATING THE AGGREGATE STATE OF BLOOD OK Gavrilov[books.google.com] Here, we studied three family members with familial azotemia, a rare autosomal dominant syndrome characterized by high plasma urea resulting from impaired urinary excretion[ncbi.nlm.nih.gov] […] phospholipids phosphorus Physiol plaquettes plasma plastic plate platelet concentrates platelet count platelet factor platelet level platelet material platelet transfusions platelet-poor[books.google.com] […] ristocetin-induced binding of patient von Willebrand factor (vWF) to platelets of patients and normal individuals in association with the absence of larger multimers from plasma[ncbi.nlm.nih.gov]

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