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764 Possible Causes for Proteins, Rapamycin Binding

Did you mean: Proteins, Rapamycin, Binding

  • Sirolimus

    , apoptosis proteins, and epithelial-mesenchymal-transition (EMT) proteins.[] - binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1).[] protein kinase mTOR.[]

  • Meningitis

    CSF protein and glucose measurements are therefore essential in management but may be neglected in clinical practice.[] Voriconazole interferes with the metabolism of several other drugs, including cyclosporine, tacrolimus, sirolimus, and warfarin, potentially leading to toxic levels of these[] […] after infection Ferric binding protein (FbpA) Iron binding Lactoferrin binding protein (LbpA) Lactoferrin binding Neiserrial surface protein A (NspA) Immunogenic surface[]

  • Lymphangioleiomyomatosis

    Mutations in TSC1 or TSC2 lead to the activation of the mammalian target of rapamycin complex-1, a kinase that regulates growth factor-dependent protein translation, cell[] After discontinuation of sirolimus, the decline in lung function resumed in the sirolimus group and paralleled that in the placebo group.[] We report here that estrogen increased LAM patient-derived cells' resistance to anoikis in vitro, accompanied by decreased accumulation of the proapoptotic protein Bim, an[]

  • Immunosuppressive Drug

    We identified several proteins and pathways as being involved in the mechanism of action of FTY720.[] Regimens could be simplified using drugs with long half-lives requiring once-daily administration, such as sirolimus.[] Clin Chem 42 : 1417 -1425, 1996 Chen J, Zheng XF, Brown EJ, Schreiber SL: Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated[]

  • Protein Losing Enteropathy

    Differential diagnoses for low protein levels are reduced intake or malnutrition, decreased protein synthesis due to hepatic dysfunctions, and protein losing nephropathy.[] At the time of writing this report, the beneficial effect of sirolimus has lasted for more than 3 years.[] She also had severe protein C and protein S depletion from GI loss which caused extensive thrombosis.[]

  • Proteinuria

    Healthy kidneys do not allow a significant amount of protein to pass through their filters.[] CASE REPORT: A 43-year-old man who received a cadaveric kidney was converted to sirolimus from cyclosporine after being diagnosed with adenocarcinoma and carcinoma clarocellulare[] […] significant complication after liver transplantation (LT), but the role of pre-existing renal insufficiency and proteinuria remains unclear among LT recipients receiving sirolimus[]

  • Low Protein Diet

    BACKGROUND & AIMS: Amino acid (AA) availability is critical to maintain protein homeostasis and reduced protein intake causes a decline in protein synthesis.[] Z Nudelman, M Friedman, D Barasch, A Nemirovski, M Findler, A Pikovsky, JS Gutkind and R Czerninski , Levels of sirolimus in saliva and blood following mouthwash application[] […] involved in intracellular signalling distal to IGF1R, which include members of the insulin-receptor substrate ( IRS ) family, AKT , target of rapamycin ( TOR ) and S6 kinase[]

  • Wiskott Aldrich Syndrome

    Abstract Wiskott–Aldrich syndrome protein family verprolin-homologous protein 2 (WAVE2) is a protein that mediates actin cytoskeletal reorganization and lamellipodia protrusion[] ) in Kidney Transplant Recipients Completed NCT00121810 Phase 4 mycophenolate mofetil [CellCept];Corticosteroids;Calcineurin inhibitors;Sirolimus 8 Drug-Drug Interaction of[] Several actin regulatory proteins were implicated in regulating the actin machinery, such as members of the Wiskott-Aldrich syndrome protein (WASp) family.[]

  • Diamond-Blackfan Anemia

    , along with rarer abnormalities of additional ribosomal proteins.[] 148-82-3 4053 460612 39 Mycophenolic acid Approved Phase 2,Phase 1,Not Applicable 24280-93-1 446541 40 Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865 41 Sirolimus[] Mutations in the ribosomal protein (RP) S19 are found in 25% of patients, while mutations in other proteins of the small ribosomal subunit--RPS17 and RPS24--have been found[]

  • Soy Allergy

    […] food proteins.[] Cyclosporin A, FK506 (tacrolimus), and rapamycin (sirolimus) are powerful immunosuppressive agents that interfere with T-cell signaling 14-4.[] Generally, these studies show lower allergic reactivity for soy proteins vs. other food allergens.[]

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