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9,742 Possible Causes for Raf, human, inhibitor, kinase, protein

Did you mean: Raf, human, inhibitor, kinase, proteus

  • Clonorchis Sinensis

    This polypeptide was homologous to taurocyamine kinase (TK) of the invertebrate animals and consisted of two contiguous domains.[] KEYWORDS: Anti-inflammatory; CsCF; CsStefin-1; Cysteine protease inhibitor; Immune modulator[] […] in a large bile duct / Clonorchis sinensis See also Opisthorchis viverrini flukes / fluke liver fluke Open references Clonorchis sinensis, an oriental liver fluke, as a human[] Elevated PKA, B-Raf, and ERK1/2 mRNA levels and phosphorylated B-Raf and ERK1/2 were detected in CsLysoPLA-stimulated RAW264.7 cells.[] We identified antigenic proteins from adult C. sinensis liver flukes using immunoproteomic analysis.[]

  • Neuroepithelioma

    All three receptors were also capable of stimulating c-Jun NH2-terminal kinases (JNK) and p38 MAPK.[] The effects of PDE inhibitors were then investigated on crude cell extracts; the calculated IC50 were 32 microM for zaprinast and 16 nM for DC-TA-46; the latter inhibitor[] In this study, overexpression of p53 was detected in 4 out of 5 human neuroblastoma-derived cell lines.[] […] a common cytogenetic rearrangement, are characterized by an indistinguishable and highly reproducible pattern of protooncogene expression. c-myc, N-myc, c-myb, and c-mil/raf[] Abstract Since Toxoplasma gondii can establish a persistent infection in the central nervous system in humans, we studied its effects on a host's neurotransmitter and neuropeptide[]

  • Fibrosarcoma

    To confirm the detailed molecular mechanisms of these effects, we measured the activation of phosphoinositide 3 kinase (PI3-kinase) and mitogen-activated protein kinase (MAPK[] KEYWORDS: Anti-cancer agents; MAPK; RAF inhibitors[] CONCLUSION: This in vitro study demonstrates the anticancer activity of resveratrol against human fibrosarcoma cells.[] Over 250 nuclear proteins captured on chromosomal DNA following treatment with cisplatin were identified, including high mobility group (HMG) proteins, histone proteins, and[] The therapeutic effect of the hydrogel loaded with doxorubicin (DOX) after intratumoral administration in mice with human fibrosarcoma was evaluated.[]

  • Ehrlichia Chaffeensis

    Here, the 2.15 Å resolution crystal structure of thymidylate kinase from E. chaffeensis in the apo form is presented.[] C [PLC] inhibitors), monodansylcadaverine (a transglutaminase [TGase] inhibitor), and genistein (a protein tyrosine kinase [PTK] inhibitor).[] Upon incubation with human monocytes, E. chaffeensis neither induced O(2)(-) generation by human monocytes, nor colocalized with nicotinamide adenine dinucleotide phosphate[] U0126 (inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 [MEK1/2] upstream of ERK), manumycin A (Ras inhibitor), BAY43-9006 (Raf[] Additional E. chaffeensis surface proteins detected were OMP85, hypothetical protein ECH_0525 (here named Esp73), immunodominant surface protein gp47, and 11 other proteins[]

  • Novobiocin

    (s), perhaps protein kinase C.[] Previous studies have shown that novobiocin, an inhibitor for breast cancer resistance proteins (BCRP), inhibited organic anion transport.[] CONCLUSIONS: The obtained data indicate that novobiocin may induce death of human gingival fibroblasts.[] Furthermore, novobiocin reduced Raf-1 levels in the spleens of mice treated with the drug.[] Abstract Novobiocin is a C-terminal inhibitor of the Hsp90 protein folding machinery, which is responsible for the conformational maturation of numerous proteins involved[]

  • Sophora

    This occurs via attenuation of extracellular signal-regulated protein (ERK) and RSK2 kinase pathways and inhibition of S6 kinase ribosomal protein (S6RP) and histone H3 S10[] The pharmacophore model generated recognized the common functional groups of known PDE10A inhibitors.[] Compared with unstimulated control, all extracts significantly reduced melanogenesis in human melanoma cells and normal adult epidermal melanocytes.[] Vexibia Raf. , Neogenyton 3. 1825. Type species: V. sericea (Nutt.) Raf. Zanthyrsis Raf. , New Fl. 3: 84. 1838. Type species: Z. paniculata Raf.[] Protein tyrosine phosphatase 1B is a non-transmembrane protein tyrosine phosphatase and major negative regulator in insulin signaling cascades, and much attention has been[]

  • Osteoblastoma

    Salinomycin induced a profound AMP-activated protein kinase (AMPK) activation, which was required for autophagy induction.[] MN1 and NF2 have previously been implicated in the development of leukemia and solid tumors, and ZNRF3 and KREMEN1 are inhibitors of the Wnt/beta-catenin signaling pathway[] KEYWORDS: Beta-human chorionic gonadotropin; Osteoblastoma, paraneoplastic; β-hCG[] Raf Sciot, Dr. Janet Shipley, Dr. Gene Siegal, Dr. Samuel Singer, Dr. Leslie H. Sobin, Dr. Poul Sorensen, Dr. Frank Speleman, Dr. Harlan Spjut, Dr. German C.[] […] cells, the latter was detected by the induction of C/EBP homologous protein (CHOP), phosphorylation of inositol-requiring enzyme 1 (IRE1) and PKR-like endoplasmic reticulum kinase[]

  • Croton

    AMP-activated protein kinase (AMPK) is a biologic sensor for cellular energy status that acts a tumor suppressor and a potential cancer therapeutic target.[] KEYWORDS: VEGF receptor-2; anti-angiogenesis; penduliflaworosin MeSH terms, Substances MeSH terms Angiogenesis Inhibitors/chemistry Angiogenesis Inhibitors/isolation & purification[] […] from Venezuela, two seco-entkaurenes isolated from flowers of Croton caracasana were evaluated in vitro for their effect on cell viability by the standard MTT assay in nine human[] Lascadium Raf. Lasiogyne Klotzsch Leontia Rchb. Leptemon Raf. Leucadenia Klotzsch ex Baill. Luntia Neck. ex Raf.[] To evaluate the potential role of sangre de grado (SdG) in cancer we examined its effects on human cancer cells, AGS (stomach), HT29 and T84 (colon).[]

  • Pneumonia

    RATIONALE: Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), a distinct molecular entity, is highly sensitive to ALK tyrosine kinase[] Organizing pneumonia induced by mTOR inhibitor treatment was initially considered.[] IMPORTANCE Human respiratory syncytial virus (RSV) is an important human pathogen that lacks a licensed vaccine or antiviral drug suitable for routine use.[] Multidrug-resistant Acinetobacter baumannii (MDRAB) pneumonia with severe sepsis in a patient with rheumatoid arthritis (RA), who is predisposed after treatment with tumor necrosis factor inhibitor[] Human-to-human transmission of the virus occurred occasionally in family clusters. However, pneumonia as an onset syndrome was not common in most SFTS cases.[]

    Missing: Raf
  • Polygonatum

    In addition, PCL treatment activated mitogen-activated protein kinase (MAPK) members extracellular signal-regulated kinase (ERK), JNK and p38, JNK inhibitor and p38 inhibitor[] SAP homoisoflavonoids and SGLT1 inhibitors were found to synergistically inhibit the uptake of glucose using an in vitro model comprising Caco-2 cells.[] In addition, POL displayed no significant cytotoxicity toward normal human embryonic lung fibroblast HELF cells.[] Additionally, we also found that POL induces MCF-7 cell apoptosis via EGFR-mediated Ras-Raf-MEK-ERK pathway, suggesting that POL may be a potential EGFR inhibitor.[] Quantitative RT-PCR and Western blot were performed to detect the mRNA and protein expressions, respectively.[]