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16 Possible Causes for SPO11

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  • Acanthamoeba

    The recently available Acanthamoeba genome revealed several genes implicated in meiosis in sexual eukaryotes such as Spo11, Mre11, Rad50, Rad51, Rad52, Mnd1, Dmc1, Msh, and[ncbi.nlm.nih.gov] The recently available Acanthamoeba genome revealed several genes implicated in meiosis in sexual eukaryotes such as Spo11 , Mre11 , Rad50 , Rad51 , Rad52 , Mnd1 , Dmc1 ,[doi.org] These genes included Spo11, Mre11, Rad50, Rad51, Rad52, Mnd1, Dmc1, Msh, and Mlh.[en.wikipedia.org]

  • Premature Ovarian Failure Type 9

    SPO11 meiotic protein covalently bound to DSB SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) SRD5A2 steroid-5[amp.pharm.mssm.edu] SMAD family member 2 SMAD3 SMAD family member 3 SMAD4 SMAD family member 4 SMAD5 SMAD family member 5 SMAD6 SMAD family member 6 SMAD7 SMAD family member 7 SPAST spastin SPO11[amp.pharm.mssm.edu]

  • Trypanosoma Brucei

    Expression of YFP::SPO11 was not detected in any life cycle stage (three independent clones analyzed; Table 1 ).[doi.org] Phylogenetic trees for meiosis-specific proteins Hop2, Mnd1, Spo11 and Mer3.[doi.org] Well-characterized proteins intrinsic to these unique processes include Spo11 ( 20 ), Mnd1, Dmc1 ( 21 ) (all three of which function in processing DNA during recombination[doi.org]

  • Ataxia Telangiectasia

    Atm / compared to Spo11 / .[doi.org] Strikingly, Spo11 /-Atm-/- spermatocytes are defective in forming the obligate crossover on the sex chromosomes, even though the XY pair is usually incorporated in a sex body[ncbi.nlm.nih.gov] For each size group, we then compared MLH1 numbers in Spo11 / Atm / vs. Spo11 / ( Table 1 ).[doi.org]

  • Oligospermia

    SPO11 meiotic protein covalently bound to DSB SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) STRA8 stimulated[amp.pharm.mssm.edu] […] member A1 SPANXA2 SPANX family, member A2 SPANXB1 SPANX family, member B1 SPANXC SPANX family, member C SPANXD SPANX family, member D SPATA22 spermatogenesis associated 22 SPO11[amp.pharm.mssm.edu]

  • Ring Chromosome 20 Syndrome

    […] peptidase inhibitor 20q13.13 snail family transcriptional repressor 1 20p11.2 Synaptosomal-associated Protein, 25-kd 20p12-p11.2 synaptosome associated protein 25kDa 20q13.31 SPO11[okdb.appliedbioinfo.net]

  • Trichomonas Vaginalis

    Phylogenetic trees for meiosis-specific proteins Hop2, Mnd1, Spo11 and Mer3.[doi.org] Spo11 ( Figure 2C ) has a prokaryotic ortholog ( Top6A ) and evolved by early eukaryotic gene duplications [49] .[doi.org] Figure 2 highlights the phylogenies of four of eight meiosis-specific proteins found in T. vaginalis : Hop2, Mnd1, Spo11 and Mer3.[doi.org]

  • UV-Sensitive Syndrome 1

    3p21.31 NM_033629 TREX2 3' exonuclease Xq28 NM_007205 EXO1 (HEX1) 5' exonuclease 1q43 NM_003686 APTX (aprataxin) Processing of DNA single-strand interruptions 9p21.1 NM_175073 SPO11[mdanderson.org]

  • Entamoeba Histolytica

    Two copies of putative SPO11 were found in E. invadens ( SPO11 a and SPO11 b).[doi.org] To initiate meiosis, the Spo11 enzyme generates DNA double-strand breaks (DSBs) throughout the genome [ 1 ].[doi.org] SPO11 , DMC1 and MND1 are meiotic specific genes.[doi.org]

  • Giardia Lamblia

    Phylogenetic trees for meiosis-specific proteins Hop2, Mnd1, Spo11 and Mer3.[doi.org] Several are well conserved (Spo11–78% aaID, Dmc1–92% aaID, Msh6–78% aaID), others are not as conserved (Mre11–62%, Rad50–60%) and some even show deletions (15 aa in Rad52)[doi.org] Spo11 ( Figure 2C ) has a prokaryotic ortholog ( Top6A ) and evolved by early eukaryotic gene duplications [49] .[doi.org]

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