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822 Possible Causes for Sarcolysine

  • Alopecia

    BACKGROUND: Studies suggest platelet-rich plasma (PRP) may mitigate androgenetic alopecia (AGA), but each varies in the frequency of and interval between treatments. OBJECTIVE: To compare the efficacy, satisfaction, tolerability, and safety of 2 initial PRP injection protocols over 6 months. METHODS: Prospective,[…][ncbi.nlm.nih.gov]

  • Neuroblastoma

    Intensification therapy includes busulfan, melphalan, and levetiracetam with peripheral blood stem cell transplantation.[clinicaltrials.gov] […] commonly used in induction and for stem cell transplant conditioning are platinum compounds ( cisplatin , carboplatin ), alkylating agents ( cyclophosphamide , ifosfamide , melphalan[en.wikipedia.org] Given IV Other Names: L-phenylalanine mustard Phenylalanine mustard L-PAM L-sarcolysin Alkeran(R) Biological: peripheral blood stem cell transplantation Transplantation of[clinicaltrials.gov]

  • Vitreous Hemorrhage

    Pars plana lensectomy, 25-G vitrectomy with melphalan irrigation (5 μg/mL), and silicone oil tamponade were performed.[ncbi.nlm.nih.gov] Thus, in unclear cases of VH with suspected viable tumor, PPV with intraocular melphalan irrigation, with caution, may be a reasonable procedure.[ncbi.nlm.nih.gov] PURPOSE: To illustrate the successful outcome of pars plana vitrectomy (PPV) with melphalan irrigation for vitreous hemorrhage (VH) with suspected viable retinoblastoma.[ncbi.nlm.nih.gov]

  • Acute Myeloid Leukemia with Multilineage Dysplasia

    Recently palliative treatment with low-dose melphalan has been reported to have certain activity.[ncbi.nlm.nih.gov] Low-dose melphalan shows significant activity in high-risk MDS and AML with multilineage dysplasia with acceptable toxicity.[ncbi.nlm.nih.gov] All of them received oral melphalan in a daily dose of 2 mg. Median total dose of the drug was 120 mg (40-840 mg). Ten patients responded to the therapy.[ncbi.nlm.nih.gov]

  • Leukostasis

    Melphalan increased monocytic adhesion to human retinal endothelial cells.[ncbi.nlm.nih.gov] Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most commonly used chemotherapeutic.[ncbi.nlm.nih.gov] METHODS: To explore reasons for the unexpected vascular toxicities, we examined the effects of melphalan, as well as carboplatin (another chemotherapeutic used with retinoblastoma[ncbi.nlm.nih.gov]

  • Cytomegalovirus Pneumonia

    Abstract A patient with multiple myeloma had pancytopenia after treatment with melphalan and prednisone and died of an interstitial pneumonia.[ncbi.nlm.nih.gov] Only when other causes have been ruled out by microbiologic, serologic, and histologic examinations should melphalan be believed to cause respiratory illness.[ncbi.nlm.nih.gov]

  • Azelaic Acid

    Melphalan was the most active drug followed by CCNU, fotemustine, and 4-HA. The most sensitive line was B16F10 and the least sensitive was SK-meL-1.[ncbi.nlm.nih.gov] We carried out MTT assays to evaluate the cytotoxicity of melphalan, lomustine (CCNU), fotemustine, and 4-Hydroxyanisole (4-HA) on three melanoma lines (B16F10, SK-MEL-28,[ncbi.nlm.nih.gov] Previous treatment with AZA of B16F10 reinforced the effect of melphalan (2.5 times), CCNU (10 times), and fotemustine (14 times); whereas for SK-MEL-28 and SK-MEL-1, only[ncbi.nlm.nih.gov]

  • Soft Tissue Sarcoma

    The majority underwent ILP (88%) versus 12% for ILI, and chemotherapeutic regimens used were as follows: (1) melphalan with tumor necrosis factor (TNF)-α (78%), (2) melphalan[ncbi.nlm.nih.gov] Similar unadjusted ORRs were noted in the melphalan treatment groups with and without TNFα (72.0 and 67.0%, respectively; p 0.27).[ncbi.nlm.nih.gov]

  • Malignant Pleural Effusion

    After failure of anti-estrogen tamoxifen, orally administered melphalan achieved excellent complete remission.[ncbi.nlm.nih.gov] A 70-year-old man was diagnosed as plasma cell leukemia and one course of ranimustine-vindesine, melphalan, and prednisolone followed by melphalan and prednisone (MP) maintained[ncbi.nlm.nih.gov] While a previous case report demonstrated a surprising cure of platinum-resistant ovarian cancer with BRCA2 mutation by orally administered melphalan.[ncbi.nlm.nih.gov]

  • Chlordiazepoxide

    For the longer time-exposure experiment, oxaziridines had the same cytotoxicity as melphalan and this toxicity was higher when oxaziridines were photogenerated in the presence[ncbi.nlm.nih.gov] […] chlordiazepoxide (CDZ) and its metabolites was investigated in vitro by a MTT assay on P388 leukemia and B16 melanoma cell lines and compared with that of the anticancer drug, melphalan[ncbi.nlm.nih.gov]

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